Pouteria ramiflora extract inhibits salivary amylolytic activity and decreases glycemic level in mice
In this study, extracts of plant species from the Cerrado biome were assessed in order to find potential inhibitors of human salivary alpha-amylase. The plants were collected and extracts were obtained from leaves, bark, and roots. We performed a preliminary phytochemical analysis and a screening fo...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2013-09-01
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| Series: | Anais da Academia Brasileira de Ciências |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000301141&lng=en&tlng=en |
| _version_ | 1817998501228838912 |
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| author | NEIRE M. DE GOUVEIA CIBELE L. DE ALBUQUERQUE LAILA S. ESPINDOLA FOUED S. ESPINDOLA |
| author_facet | NEIRE M. DE GOUVEIA CIBELE L. DE ALBUQUERQUE LAILA S. ESPINDOLA FOUED S. ESPINDOLA |
| author_sort | NEIRE M. DE GOUVEIA |
| collection | DOAJ |
| description | In this study, extracts of plant species from the Cerrado biome were assessed in order to find potential inhibitors of human salivary alpha-amylase. The plants were collected and extracts were obtained from leaves, bark, and roots. We performed a preliminary phytochemical analysis and a screening for salivar alpha-amylase inhibitory activity. Only three botanical families (Sapotaceae, Sapindaceae and Flacourtiaceae) and 16 extracts showed a substantial inhibition (>75%) of alpha-amylase. The ethanolic extracts of Pouteria ramiflora obtained from stem barks and root barks decreased amylolytic activity above 95% at a final concentration of 20 µg/mL. Thus, adult male Swiss mice were treated orally with P. ramiflora in acute toxicity and glycemic control studies. Daily administration with 25, 50 and 100 mg/kg of aqueous extract of P. ramiflora for eight days can reduce significantly body weight and blood glucose level in mice. These data suggest that the crude polar extract of P. ramiflora decreases salivary amylolytic activity while lowering the blood levels of glucose. |
| first_indexed | 2024-04-14T02:55:03Z |
| format | Article |
| id | doaj.art-c38c512fae0541e78c20750505262ec6 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-04-14T02:55:03Z |
| publishDate | 2013-09-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-c38c512fae0541e78c20750505262ec62022-12-22T02:16:10ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902013-09-018531141114810.1590/S0001-37652013000300016S0001-37652013000301141Pouteria ramiflora extract inhibits salivary amylolytic activity and decreases glycemic level in miceNEIRE M. DE GOUVEIACIBELE L. DE ALBUQUERQUELAILA S. ESPINDOLAFOUED S. ESPINDOLAIn this study, extracts of plant species from the Cerrado biome were assessed in order to find potential inhibitors of human salivary alpha-amylase. The plants were collected and extracts were obtained from leaves, bark, and roots. We performed a preliminary phytochemical analysis and a screening for salivar alpha-amylase inhibitory activity. Only three botanical families (Sapotaceae, Sapindaceae and Flacourtiaceae) and 16 extracts showed a substantial inhibition (>75%) of alpha-amylase. The ethanolic extracts of Pouteria ramiflora obtained from stem barks and root barks decreased amylolytic activity above 95% at a final concentration of 20 µg/mL. Thus, adult male Swiss mice were treated orally with P. ramiflora in acute toxicity and glycemic control studies. Daily administration with 25, 50 and 100 mg/kg of aqueous extract of P. ramiflora for eight days can reduce significantly body weight and blood glucose level in mice. These data suggest that the crude polar extract of P. ramiflora decreases salivary amylolytic activity while lowering the blood levels of glucose.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000301141&lng=en&tlng=eninibicao da alfa-amilasehipoglicemiantePouteria ramifloraSapotaceae |
| spellingShingle | NEIRE M. DE GOUVEIA CIBELE L. DE ALBUQUERQUE LAILA S. ESPINDOLA FOUED S. ESPINDOLA Pouteria ramiflora extract inhibits salivary amylolytic activity and decreases glycemic level in mice Anais da Academia Brasileira de Ciências inibicao da alfa-amilase hipoglicemiante Pouteria ramiflora Sapotaceae |
| title | Pouteria ramiflora extract inhibits salivary amylolytic activity and decreases glycemic level in mice |
| title_full | Pouteria ramiflora extract inhibits salivary amylolytic activity and decreases glycemic level in mice |
| title_fullStr | Pouteria ramiflora extract inhibits salivary amylolytic activity and decreases glycemic level in mice |
| title_full_unstemmed | Pouteria ramiflora extract inhibits salivary amylolytic activity and decreases glycemic level in mice |
| title_short | Pouteria ramiflora extract inhibits salivary amylolytic activity and decreases glycemic level in mice |
| title_sort | pouteria ramiflora extract inhibits salivary amylolytic activity and decreases glycemic level in mice |
| topic | inibicao da alfa-amilase hipoglicemiante Pouteria ramiflora Sapotaceae |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000301141&lng=en&tlng=en |
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