Vitamin D and Autoimmune Rheumatic Diseases
Vitamin D is a steroid hormone with potent immune-modulating properties. It has been shown to stimulate innate immunity and induce immune tolerance. Extensive research efforts have shown that vitamin D deficiency may be related to the development of autoimmune diseases. Vitamin D deficiency has been...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/4/709 |
| _version_ | 1797606238151770112 |
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| author | Lambros Athanassiou Ifigenia Kostoglou-Athanassiou Michael Koutsilieris Yehuda Shoenfeld |
| author_facet | Lambros Athanassiou Ifigenia Kostoglou-Athanassiou Michael Koutsilieris Yehuda Shoenfeld |
| author_sort | Lambros Athanassiou |
| collection | DOAJ |
| description | Vitamin D is a steroid hormone with potent immune-modulating properties. It has been shown to stimulate innate immunity and induce immune tolerance. Extensive research efforts have shown that vitamin D deficiency may be related to the development of autoimmune diseases. Vitamin D deficiency has been observed in patients with rheumatoid arthritis (RA) and has been shown to be inversely related to disease activity. Moreover, vitamin D deficiency may be implicated in the pathogenesis of the disease. Vitamin D deficiency has also been observed in patients with systemic lupus erythematosus (SLE). It has been found to be inversely related to disease activity and renal involvement. In addition, vitamin D receptor polymorphisms have been studied in SLE. Vitamin D levels have been studied in patients with Sjogren’s syndrome, and vitamin D deficiency may be related to neuropathy and the development of lymphoma in the context of Sjogren’s syndrome. Vitamin D deficiency has been observed in ankylosing spondylitis, psoriatic arthritis (PsA), and idiopathic inflammatory myopathies. Vitamin D deficiency has also been observed in systemic sclerosis. Vitamin D deficiency may be implicated in the pathogenesis of autoimmunity, and it may be administered to prevent autoimmune disease and reduce pain in the context of autoimmune rheumatic disorders. |
| first_indexed | 2024-03-11T05:12:22Z |
| format | Article |
| id | doaj.art-c3905dbdb0ae4c2d8a9a28a1c928001b |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T05:12:22Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-c3905dbdb0ae4c2d8a9a28a1c928001b2023-11-17T18:30:14ZengMDPI AGBiomolecules2218-273X2023-04-0113470910.3390/biom13040709Vitamin D and Autoimmune Rheumatic DiseasesLambros Athanassiou0Ifigenia Kostoglou-Athanassiou1Michael Koutsilieris2Yehuda Shoenfeld3Department of Rheumatology, Asclepeion Hospital, Voula, GR16673 Athens, GreeceDepartment of Endocrinology, Asclepeion Hospital, Voula, GR16673 Athens, GreeceDepartment of Physiology, Medical School, University of Athens, GR11527 Athens, GreeceZabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv University, Tel Aviv 69978, IsraelVitamin D is a steroid hormone with potent immune-modulating properties. It has been shown to stimulate innate immunity and induce immune tolerance. Extensive research efforts have shown that vitamin D deficiency may be related to the development of autoimmune diseases. Vitamin D deficiency has been observed in patients with rheumatoid arthritis (RA) and has been shown to be inversely related to disease activity. Moreover, vitamin D deficiency may be implicated in the pathogenesis of the disease. Vitamin D deficiency has also been observed in patients with systemic lupus erythematosus (SLE). It has been found to be inversely related to disease activity and renal involvement. In addition, vitamin D receptor polymorphisms have been studied in SLE. Vitamin D levels have been studied in patients with Sjogren’s syndrome, and vitamin D deficiency may be related to neuropathy and the development of lymphoma in the context of Sjogren’s syndrome. Vitamin D deficiency has been observed in ankylosing spondylitis, psoriatic arthritis (PsA), and idiopathic inflammatory myopathies. Vitamin D deficiency has also been observed in systemic sclerosis. Vitamin D deficiency may be implicated in the pathogenesis of autoimmunity, and it may be administered to prevent autoimmune disease and reduce pain in the context of autoimmune rheumatic disorders.https://www.mdpi.com/2218-273X/13/4/709vitamin Drheumatoid arthritissystemic lupus erythematosusankylosing spondylitisSjogren’s syndromesystemic sclerosis |
| spellingShingle | Lambros Athanassiou Ifigenia Kostoglou-Athanassiou Michael Koutsilieris Yehuda Shoenfeld Vitamin D and Autoimmune Rheumatic Diseases Biomolecules vitamin D rheumatoid arthritis systemic lupus erythematosus ankylosing spondylitis Sjogren’s syndrome systemic sclerosis |
| title | Vitamin D and Autoimmune Rheumatic Diseases |
| title_full | Vitamin D and Autoimmune Rheumatic Diseases |
| title_fullStr | Vitamin D and Autoimmune Rheumatic Diseases |
| title_full_unstemmed | Vitamin D and Autoimmune Rheumatic Diseases |
| title_short | Vitamin D and Autoimmune Rheumatic Diseases |
| title_sort | vitamin d and autoimmune rheumatic diseases |
| topic | vitamin D rheumatoid arthritis systemic lupus erythematosus ankylosing spondylitis Sjogren’s syndrome systemic sclerosis |
| url | https://www.mdpi.com/2218-273X/13/4/709 |
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