Therapeutic effectiveness of Ocimum basilicum extract on bovine cutaneous papillomatosis
Bovine cutaneous papillomatosis is a common cutaneous disease of cattle in the Egyptian veterinary field. Ocimum basilicum L. (Rehan) is one of the aromatic plants originating in Asia and Africa. Many studies showed that Ocimum basilicum has interesting antiviral and anticancer activities. However...
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| Format: | Article |
| Language: | English |
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South Valley University
2020-09-01
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| Series: | SVU-International Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://svu.journals.ekb.eg/article_112992.html |
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| author | AbdulRahman A. Saied Ashraf A. El-Ghoneimy Abdel-latif Seddek Sary Kh. AbdelGhafar Samy A.F. Morad |
| author_facet | AbdulRahman A. Saied Ashraf A. El-Ghoneimy Abdel-latif Seddek Sary Kh. AbdelGhafar Samy A.F. Morad |
| author_sort | AbdulRahman A. Saied |
| collection | DOAJ |
| description | Bovine cutaneous papillomatosis is a common cutaneous disease of cattle in the Egyptian veterinary
field. Ocimum basilicum L. (Rehan) is one of the aromatic plants originating in Asia and Africa. Many
studies showed that Ocimum basilicum has interesting antiviral and anticancer activities. However, there
is no report demonstrating the clinical significance of the anti-papilloma activity of Ocimum basilicum
against bovine skin papillomas. Thus, our study was designed to evaluate the therapeutic potential of
Ocimum basilicum extract (OBEx) as an anti-papilloma agent against bovine papillomatosis. OBEx was
prepared and undergone phytochemical analysis that revealed presence of alkaloids, phenolics, and
flavonoids. Ten cutaneous papillomatosis-infected cattle were diagnosed clinically and
histopathologically. Animals were treated with OBEx ointment 2% that topically applied daily and
papillomas regression was recorded weekly. Clinically, papillomas started to disappear from the 7th
- 21st
day after the start of treatment. Histopathological analysis showed improvement in histological features of
wart tissue returning to the normal skin structure with presence of lymphocytic infiltration. We concluded
that the topical application of OBEx is an effective, promising alternative, cheap, and easily apply agent
for treatment of skin papilloma. |
| first_indexed | 2024-12-13T22:48:03Z |
| format | Article |
| id | doaj.art-c3907297413443dbb077f66c9414bcd5 |
| institution | Directory Open Access Journal |
| issn | 2535-1826 2535-1877 |
| language | English |
| last_indexed | 2024-12-13T22:48:03Z |
| publishDate | 2020-09-01 |
| publisher | South Valley University |
| record_format | Article |
| series | SVU-International Journal of Veterinary Sciences |
| spelling | doaj.art-c3907297413443dbb077f66c9414bcd52022-12-21T23:28:41ZengSouth Valley UniversitySVU-International Journal of Veterinary Sciences2535-18262535-18772020-09-0132607710.21608/svu.2020.35596.1067Therapeutic effectiveness of Ocimum basilicum extract on bovine cutaneous papillomatosisAbdulRahman A. Saied0 Ashraf A. El-Ghoneimy1Abdel-latif Seddek2Sary Kh. AbdelGhafar 3Samy A.F. Morad4 Department of Pharmacology, Faculty of Veterinary Medicine, South Valley University, Qena, 83523, Egypt.Department of Pharmacology, Faculty of Veterinary Medicine, South Valley University, Qena, 83523, Egypt Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena, 83523, EgyptDepartment of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, 71526, Egypt.Department of Pharmacology, Faculty of Veterinary Medicine, South Valley University, Qena, 83523, EgyptBovine cutaneous papillomatosis is a common cutaneous disease of cattle in the Egyptian veterinary field. Ocimum basilicum L. (Rehan) is one of the aromatic plants originating in Asia and Africa. Many studies showed that Ocimum basilicum has interesting antiviral and anticancer activities. However, there is no report demonstrating the clinical significance of the anti-papilloma activity of Ocimum basilicum against bovine skin papillomas. Thus, our study was designed to evaluate the therapeutic potential of Ocimum basilicum extract (OBEx) as an anti-papilloma agent against bovine papillomatosis. OBEx was prepared and undergone phytochemical analysis that revealed presence of alkaloids, phenolics, and flavonoids. Ten cutaneous papillomatosis-infected cattle were diagnosed clinically and histopathologically. Animals were treated with OBEx ointment 2% that topically applied daily and papillomas regression was recorded weekly. Clinically, papillomas started to disappear from the 7th - 21st day after the start of treatment. Histopathological analysis showed improvement in histological features of wart tissue returning to the normal skin structure with presence of lymphocytic infiltration. We concluded that the topical application of OBEx is an effective, promising alternative, cheap, and easily apply agent for treatment of skin papilloma.https://svu.journals.ekb.eg/article_112992.htmlbasil leaf (ocimum basilicum)clinicopathologicalbovine cutaneous papillomatosiseffectiveness |
| spellingShingle | AbdulRahman A. Saied Ashraf A. El-Ghoneimy Abdel-latif Seddek Sary Kh. AbdelGhafar Samy A.F. Morad Therapeutic effectiveness of Ocimum basilicum extract on bovine cutaneous papillomatosis SVU-International Journal of Veterinary Sciences basil leaf (ocimum basilicum) clinicopathological bovine cutaneous papillomatosis effectiveness |
| title | Therapeutic effectiveness of Ocimum basilicum extract on bovine cutaneous papillomatosis |
| title_full | Therapeutic effectiveness of Ocimum basilicum extract on bovine cutaneous papillomatosis |
| title_fullStr | Therapeutic effectiveness of Ocimum basilicum extract on bovine cutaneous papillomatosis |
| title_full_unstemmed | Therapeutic effectiveness of Ocimum basilicum extract on bovine cutaneous papillomatosis |
| title_short | Therapeutic effectiveness of Ocimum basilicum extract on bovine cutaneous papillomatosis |
| title_sort | therapeutic effectiveness of ocimum basilicum extract on bovine cutaneous papillomatosis |
| topic | basil leaf (ocimum basilicum) clinicopathological bovine cutaneous papillomatosis effectiveness |
| url | https://svu.journals.ekb.eg/article_112992.html |
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