Effects of β-Lactolin on Regional Cerebral Blood Flow within the Dorsolateral Prefrontal Cortex during Working Memory Task in Healthy Adults: A Randomized Controlled Trial
Epidemiological studies have reported that consumption of dairy products rich in β-lactolin is beneficial for cognitive decline among elderly individuals. Although previous studies have shown that β-lactolin supplementation improves memory function and attention in healthy adults, the mechanism thro...
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MDPI AG
2021-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/3/480 |
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| author | Yasuhisa Ano Masahiro Kita Keiko Kobayashi Takashi Koikeda Ryuta Kawashima |
| author_facet | Yasuhisa Ano Masahiro Kita Keiko Kobayashi Takashi Koikeda Ryuta Kawashima |
| author_sort | Yasuhisa Ano |
| collection | DOAJ |
| description | Epidemiological studies have reported that consumption of dairy products rich in β-lactolin is beneficial for cognitive decline among elderly individuals. Although previous studies have shown that β-lactolin supplementation improves memory function and attention in healthy adults, the mechanism through which β-lactolin affects human brain function has yet to be elucidated. This placebo-controlled randomized double-blind study therefore examined the effects of β-lactolin on human regional cerebral blood flow (rCBF) using near-infrared spectroscopy (NIRS) according to the Consolidated Standards of Reporting Trials guidelines. A total of 114 healthy participants aged between 50 and 75 years with relatively low cognition were randomly allocated into the β-lactolin or placebo groups (<i>n</i> = 57 for both groups) and received supplementation for 6 weeks. After the 6 weeks of supplementation, total hemoglobin during cognitive tasks (Kraepelin and 2-back tasks) was measured using two-channel NIRS to determine rCBF. Accordingly, the β-lactolin group had significantly higher changes in total hemoglobin at the left dorsolateral prefrontal cortex (DLPFC) area measured using the left-side channel during the 2-back tasks (<i>p</i> = 0.027) compared to the placebo group. The present study suggests that β-lactolin supplementation increases rCBF and DLPFC activity during working memory tasks. |
| first_indexed | 2024-03-09T03:24:47Z |
| format | Article |
| id | doaj.art-c390b75cad5a4866981d712f41fdf34a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T03:24:47Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c390b75cad5a4866981d712f41fdf34a2023-12-03T15:04:06ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110348010.3390/jcm10030480Effects of β-Lactolin on Regional Cerebral Blood Flow within the Dorsolateral Prefrontal Cortex during Working Memory Task in Healthy Adults: A Randomized Controlled TrialYasuhisa Ano0Masahiro Kita1Keiko Kobayashi2Takashi Koikeda3Ryuta Kawashima4Kirin Central Research Institute, Kirin Holdings Company, Ltd., 26-1, Muraoka-Higashi 2, Fujisawa Kanagawa 251-8555, JapanKirin Central Research Institute, Kirin Holdings Company, Ltd., 26-1, Muraoka-Higashi 2, Fujisawa Kanagawa 251-8555, JapanKirin Central Research Institute, Kirin Holdings Company, Ltd., 26-1, Muraoka-Higashi 2, Fujisawa Kanagawa 251-8555, JapanShiba Palace Clinic, Daiwa A Hamamatsucho 6F, 1-9-10, Hamamatsucho, Minato-ku, Tokyo 105-0013, JapanInstitute of Development, Aging and Cancer (IDAC), Tohoku University, 4-1 Seiryo, Aoba-ku, Sendai 980-8575, JapanEpidemiological studies have reported that consumption of dairy products rich in β-lactolin is beneficial for cognitive decline among elderly individuals. Although previous studies have shown that β-lactolin supplementation improves memory function and attention in healthy adults, the mechanism through which β-lactolin affects human brain function has yet to be elucidated. This placebo-controlled randomized double-blind study therefore examined the effects of β-lactolin on human regional cerebral blood flow (rCBF) using near-infrared spectroscopy (NIRS) according to the Consolidated Standards of Reporting Trials guidelines. A total of 114 healthy participants aged between 50 and 75 years with relatively low cognition were randomly allocated into the β-lactolin or placebo groups (<i>n</i> = 57 for both groups) and received supplementation for 6 weeks. After the 6 weeks of supplementation, total hemoglobin during cognitive tasks (Kraepelin and 2-back tasks) was measured using two-channel NIRS to determine rCBF. Accordingly, the β-lactolin group had significantly higher changes in total hemoglobin at the left dorsolateral prefrontal cortex (DLPFC) area measured using the left-side channel during the 2-back tasks (<i>p</i> = 0.027) compared to the placebo group. The present study suggests that β-lactolin supplementation increases rCBF and DLPFC activity during working memory tasks.https://www.mdpi.com/2077-0383/10/3/480β-lactolincerebral blood flowdorsolateral prefrontal cortexnear-infrared spectroscopywheyworking memory |
| spellingShingle | Yasuhisa Ano Masahiro Kita Keiko Kobayashi Takashi Koikeda Ryuta Kawashima Effects of β-Lactolin on Regional Cerebral Blood Flow within the Dorsolateral Prefrontal Cortex during Working Memory Task in Healthy Adults: A Randomized Controlled Trial Journal of Clinical Medicine β-lactolin cerebral blood flow dorsolateral prefrontal cortex near-infrared spectroscopy whey working memory |
| title | Effects of β-Lactolin on Regional Cerebral Blood Flow within the Dorsolateral Prefrontal Cortex during Working Memory Task in Healthy Adults: A Randomized Controlled Trial |
| title_full | Effects of β-Lactolin on Regional Cerebral Blood Flow within the Dorsolateral Prefrontal Cortex during Working Memory Task in Healthy Adults: A Randomized Controlled Trial |
| title_fullStr | Effects of β-Lactolin on Regional Cerebral Blood Flow within the Dorsolateral Prefrontal Cortex during Working Memory Task in Healthy Adults: A Randomized Controlled Trial |
| title_full_unstemmed | Effects of β-Lactolin on Regional Cerebral Blood Flow within the Dorsolateral Prefrontal Cortex during Working Memory Task in Healthy Adults: A Randomized Controlled Trial |
| title_short | Effects of β-Lactolin on Regional Cerebral Blood Flow within the Dorsolateral Prefrontal Cortex during Working Memory Task in Healthy Adults: A Randomized Controlled Trial |
| title_sort | effects of β lactolin on regional cerebral blood flow within the dorsolateral prefrontal cortex during working memory task in healthy adults a randomized controlled trial |
| topic | β-lactolin cerebral blood flow dorsolateral prefrontal cortex near-infrared spectroscopy whey working memory |
| url | https://www.mdpi.com/2077-0383/10/3/480 |
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