Cell death as a defense strategy against pathogens in plants and animals.
Eukaryotes are endowed with sophisticated innate immune systems to recognize non-self and halt pathogen proliferation. Activation of cell death at the site of attempted pathogen ingress is a common strategy used by plants and animals to restrict pathogen proliferation and trigger immune responses in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-04-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1011253 |
| _version_ | 1827968568321376256 |
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| author | Jose Salguero-Linares Nuria S Coll |
| author_facet | Jose Salguero-Linares Nuria S Coll |
| author_sort | Jose Salguero-Linares |
| collection | DOAJ |
| description | Eukaryotes are endowed with sophisticated innate immune systems to recognize non-self and halt pathogen proliferation. Activation of cell death at the site of attempted pathogen ingress is a common strategy used by plants and animals to restrict pathogen proliferation and trigger immune responses in the surrounding tissues. As such, immunogenic cell death shares several features in both plants and animals that will be discussed in this article, namely: (i) it is triggered by activation of NLR immune receptors-often through oligomerization; (ii) it results in disruption of the plasma membrane (PM)/endomembrane integrity driving an imbalance in ion fluxes; and (iii) it results in the release of signaling molecules from dying cells. |
| first_indexed | 2024-04-09T18:23:36Z |
| format | Article |
| id | doaj.art-c39124790c6b461989cae1aec9cfbfc8 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-04-09T18:23:36Z |
| publishDate | 2023-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-c39124790c6b461989cae1aec9cfbfc82023-04-12T05:31:35ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742023-04-01194e101125310.1371/journal.ppat.1011253Cell death as a defense strategy against pathogens in plants and animals.Jose Salguero-LinaresNuria S CollEukaryotes are endowed with sophisticated innate immune systems to recognize non-self and halt pathogen proliferation. Activation of cell death at the site of attempted pathogen ingress is a common strategy used by plants and animals to restrict pathogen proliferation and trigger immune responses in the surrounding tissues. As such, immunogenic cell death shares several features in both plants and animals that will be discussed in this article, namely: (i) it is triggered by activation of NLR immune receptors-often through oligomerization; (ii) it results in disruption of the plasma membrane (PM)/endomembrane integrity driving an imbalance in ion fluxes; and (iii) it results in the release of signaling molecules from dying cells.https://doi.org/10.1371/journal.ppat.1011253 |
| spellingShingle | Jose Salguero-Linares Nuria S Coll Cell death as a defense strategy against pathogens in plants and animals. PLoS Pathogens |
| title | Cell death as a defense strategy against pathogens in plants and animals. |
| title_full | Cell death as a defense strategy against pathogens in plants and animals. |
| title_fullStr | Cell death as a defense strategy against pathogens in plants and animals. |
| title_full_unstemmed | Cell death as a defense strategy against pathogens in plants and animals. |
| title_short | Cell death as a defense strategy against pathogens in plants and animals. |
| title_sort | cell death as a defense strategy against pathogens in plants and animals |
| url | https://doi.org/10.1371/journal.ppat.1011253 |
| work_keys_str_mv | AT josesalguerolinares celldeathasadefensestrategyagainstpathogensinplantsandanimals AT nuriascoll celldeathasadefensestrategyagainstpathogensinplantsandanimals |