Anti-Inflammatory Properties and Gut Microbiota Modulation of <i>Porphyra tenera</i> Extracts in Dextran Sodium Sulfate-Induced Colitis in Mice
<i>Porphyra tenera</i> (PT) is a functional seaweed food that has been reported for health benefits such as antioxidant, immunostimulant, anti-inflammation, and hepatoprotective effects. In this study, we investigated the effect of PT extracts on gut microbiota modulation in colitis-indu...
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MDPI AG
2020-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/10/988 |
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| author | Jungman Kim Jae Ho Choi Gwangpyo Ko Hyejun Jo Taehwan Oh Byungjae Ahn Tatsuya Unno |
| author_facet | Jungman Kim Jae Ho Choi Gwangpyo Ko Hyejun Jo Taehwan Oh Byungjae Ahn Tatsuya Unno |
| author_sort | Jungman Kim |
| collection | DOAJ |
| description | <i>Porphyra tenera</i> (PT) is a functional seaweed food that has been reported for health benefits such as antioxidant, immunostimulant, anti-inflammation, and hepatoprotective effects. In this study, we investigated the effect of PT extracts on gut microbiota modulation in colitis-induced mice. The mice experiment was designed as three groups including normal mice (CTL), dextran sodium sulfate (DSS)-fed mice, and DSS plus PT extracts-fed mice (PTE). DSS was administrated through drinking water containing DSS for 1 week, and the PT extract was ingested into the gastrointestinal tract in mice. PT extract ameliorated the decreased body weight and colon length and improved disease activity index and pro-inflammatory cytokine expression. In addition, PT extract significantly shifted the gut microbiota of mice. DSS treatment significantly increased the portion of harmful bacteria (i.e., <i>Helicobacter</i>, <i>Mucipirillum</i>, and <i>Parasutterella</i>) and decreased the butyrate producing bacteria (i.e., <i>Acetatifactor</i>, <i>Alistipes</i>, <i>Oscillibacter</i>, and <i>Clostridium_XIVb</i>). PT extract increased the abundance of genera <i>Clostridium_XIVb</i> and also enriched some of predicted metabolic activities such as glyoxylate cycle, ethylmalonyl-CoA pathway, nitrate reduction, creatinine degradation, and glycine betaine metabolism. These results suggest that PT extract may ameliorate the DSS-induced colitis inflammation through regulating the compositions and functions of gut microbiota in mice. |
| first_indexed | 2024-03-10T15:39:49Z |
| format | Article |
| id | doaj.art-c394489131d94e8394f91737c947059d |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T15:39:49Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-c394489131d94e8394f91737c947059d2023-11-20T16:58:22ZengMDPI AGAntioxidants2076-39212020-10-0191098810.3390/antiox9100988Anti-Inflammatory Properties and Gut Microbiota Modulation of <i>Porphyra tenera</i> Extracts in Dextran Sodium Sulfate-Induced Colitis in MiceJungman Kim0Jae Ho Choi1Gwangpyo Ko2Hyejun Jo3Taehwan Oh4Byungjae Ahn5Tatsuya Unno6Faculty of Biotechnology, School of Life Sciences, SARI, Jeju National University, Jeju 63243, KoreaSubtropical/Tropical Organism Gene Bank, Jeju National University, Jeju 63243, KoreaFaculty of Biotechnology, School of Life Sciences, SARI, Jeju National University, Jeju 63243, KoreaFaculty of Biotechnology, School of Life Sciences, SARI, Jeju National University, Jeju 63243, KoreaMarine Biotechnology Research Center, Jeonnam Bioindustry Foundation, Wando 59108, KoreaMarine Biotechnology Research Center, Jeonnam Bioindustry Foundation, Wando 59108, KoreaFaculty of Biotechnology, School of Life Sciences, SARI, Jeju National University, Jeju 63243, Korea<i>Porphyra tenera</i> (PT) is a functional seaweed food that has been reported for health benefits such as antioxidant, immunostimulant, anti-inflammation, and hepatoprotective effects. In this study, we investigated the effect of PT extracts on gut microbiota modulation in colitis-induced mice. The mice experiment was designed as three groups including normal mice (CTL), dextran sodium sulfate (DSS)-fed mice, and DSS plus PT extracts-fed mice (PTE). DSS was administrated through drinking water containing DSS for 1 week, and the PT extract was ingested into the gastrointestinal tract in mice. PT extract ameliorated the decreased body weight and colon length and improved disease activity index and pro-inflammatory cytokine expression. In addition, PT extract significantly shifted the gut microbiota of mice. DSS treatment significantly increased the portion of harmful bacteria (i.e., <i>Helicobacter</i>, <i>Mucipirillum</i>, and <i>Parasutterella</i>) and decreased the butyrate producing bacteria (i.e., <i>Acetatifactor</i>, <i>Alistipes</i>, <i>Oscillibacter</i>, and <i>Clostridium_XIVb</i>). PT extract increased the abundance of genera <i>Clostridium_XIVb</i> and also enriched some of predicted metabolic activities such as glyoxylate cycle, ethylmalonyl-CoA pathway, nitrate reduction, creatinine degradation, and glycine betaine metabolism. These results suggest that PT extract may ameliorate the DSS-induced colitis inflammation through regulating the compositions and functions of gut microbiota in mice.https://www.mdpi.com/2076-3921/9/10/988<i>Porphyra tenera</i>colitisgut microbiotainflammation |
| spellingShingle | Jungman Kim Jae Ho Choi Gwangpyo Ko Hyejun Jo Taehwan Oh Byungjae Ahn Tatsuya Unno Anti-Inflammatory Properties and Gut Microbiota Modulation of <i>Porphyra tenera</i> Extracts in Dextran Sodium Sulfate-Induced Colitis in Mice Antioxidants <i>Porphyra tenera</i> colitis gut microbiota inflammation |
| title | Anti-Inflammatory Properties and Gut Microbiota Modulation of <i>Porphyra tenera</i> Extracts in Dextran Sodium Sulfate-Induced Colitis in Mice |
| title_full | Anti-Inflammatory Properties and Gut Microbiota Modulation of <i>Porphyra tenera</i> Extracts in Dextran Sodium Sulfate-Induced Colitis in Mice |
| title_fullStr | Anti-Inflammatory Properties and Gut Microbiota Modulation of <i>Porphyra tenera</i> Extracts in Dextran Sodium Sulfate-Induced Colitis in Mice |
| title_full_unstemmed | Anti-Inflammatory Properties and Gut Microbiota Modulation of <i>Porphyra tenera</i> Extracts in Dextran Sodium Sulfate-Induced Colitis in Mice |
| title_short | Anti-Inflammatory Properties and Gut Microbiota Modulation of <i>Porphyra tenera</i> Extracts in Dextran Sodium Sulfate-Induced Colitis in Mice |
| title_sort | anti inflammatory properties and gut microbiota modulation of i porphyra tenera i extracts in dextran sodium sulfate induced colitis in mice |
| topic | <i>Porphyra tenera</i> colitis gut microbiota inflammation |
| url | https://www.mdpi.com/2076-3921/9/10/988 |
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