Cardiovascular complications in COVID‐19 patients with or without diabetes mellitus
Abstract Introduction Coronavirus disease 2019 (COVID‐19) has become a major global crisis. Preliminary reports have, in general, indicated worse outcomes in diabetes mellitus (DM) patients, but the magnitude of cardiovascular (CV) complications in this subgroup has not been elucidated. Methods We i...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-04-01
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| Series: | Endocrinology, Diabetes & Metabolism |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/edm2.218 |
| _version_ | 1818418836960968704 |
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| author | Temidayo Abe Obiora Egbuche Joseph Igwe Opeyemi Jegede Bivek Wagle Titilope Olanipekun Anekwe Onwuanyi |
| author_facet | Temidayo Abe Obiora Egbuche Joseph Igwe Opeyemi Jegede Bivek Wagle Titilope Olanipekun Anekwe Onwuanyi |
| author_sort | Temidayo Abe |
| collection | DOAJ |
| description | Abstract Introduction Coronavirus disease 2019 (COVID‐19) has become a major global crisis. Preliminary reports have, in general, indicated worse outcomes in diabetes mellitus (DM) patients, but the magnitude of cardiovascular (CV) complications in this subgroup has not been elucidated. Methods We included 142 patients admitted with laboratory‐confirmed COVID‐19 from April 1st to May 30th 2020; 71 (50%) had DM. We compared baseline demographics and study outcomes between those with or without DM using descriptive statistics. Multivariate logistic regression was used to estimate the adjusted odds ratio for the study outcomes in DM patients, compared to those without DM, stratified by age, sex and glycaemic control. CV outcomes of interest include acute myocarditis, acute heart failure, acute myocardial infarction, new‐onset atrial fibrillation and composite cardiovascular end‐point consisting of all individual outcomes above. Result Mean age was 58 years. The unadjusted rates were higher in DM patients compared to non‐diabetics for the composite cardiovascular end‐point (73.2% vs. 40.6% p < .0001), acute myocarditis (36.6% vs. 15.5% p = .004), acute heart failure (25.3% vs. 5.6% p = .001), acute myocardial infarction (9.9% vs. 1.4% p = .03) and new‐onset atrial fibrillation (12.7% vs. 1.4% p = .009). After controlling for relevant confounding variables, diabetic patients had higher odds of composite cardiovascular end‐point, acute heart failure and new‐onset atrial fibrillation. |
| first_indexed | 2024-12-14T12:29:01Z |
| format | Article |
| id | doaj.art-c394e39191234c9299ed038a23501478 |
| institution | Directory Open Access Journal |
| issn | 2398-9238 |
| language | English |
| last_indexed | 2024-12-14T12:29:01Z |
| publishDate | 2021-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj.art-c394e39191234c9299ed038a235014782022-12-21T23:01:14ZengWileyEndocrinology, Diabetes & Metabolism2398-92382021-04-0142n/an/a10.1002/edm2.218Cardiovascular complications in COVID‐19 patients with or without diabetes mellitusTemidayo Abe0Obiora Egbuche1Joseph Igwe2Opeyemi Jegede3Bivek Wagle4Titilope Olanipekun5Anekwe Onwuanyi6Internal Medicine Residency Program Morehouse School of Medicine Atlanta GA USADepartment of Cardiovascular Disease Morehouse School of Medicine Atlanta GA USAInternal Medicine Residency Program Morehouse School of Medicine Atlanta GA USADepartment of Epidemiology and Biostatistics University of North Texas Health Science Center Fort Worth TX USADepartment of Medicine Morehouse School of Medicine Atlanta GA USADepartment of Hospital Medicine Covenant Heart System Knoxville TN USADepartment of Cardiovascular Disease Morehouse School of Medicine Atlanta GA USAAbstract Introduction Coronavirus disease 2019 (COVID‐19) has become a major global crisis. Preliminary reports have, in general, indicated worse outcomes in diabetes mellitus (DM) patients, but the magnitude of cardiovascular (CV) complications in this subgroup has not been elucidated. Methods We included 142 patients admitted with laboratory‐confirmed COVID‐19 from April 1st to May 30th 2020; 71 (50%) had DM. We compared baseline demographics and study outcomes between those with or without DM using descriptive statistics. Multivariate logistic regression was used to estimate the adjusted odds ratio for the study outcomes in DM patients, compared to those without DM, stratified by age, sex and glycaemic control. CV outcomes of interest include acute myocarditis, acute heart failure, acute myocardial infarction, new‐onset atrial fibrillation and composite cardiovascular end‐point consisting of all individual outcomes above. Result Mean age was 58 years. The unadjusted rates were higher in DM patients compared to non‐diabetics for the composite cardiovascular end‐point (73.2% vs. 40.6% p < .0001), acute myocarditis (36.6% vs. 15.5% p = .004), acute heart failure (25.3% vs. 5.6% p = .001), acute myocardial infarction (9.9% vs. 1.4% p = .03) and new‐onset atrial fibrillation (12.7% vs. 1.4% p = .009). After controlling for relevant confounding variables, diabetic patients had higher odds of composite cardiovascular end‐point, acute heart failure and new‐onset atrial fibrillation.https://doi.org/10.1002/edm2.218cardiovascular complicationsCOVID‐19diabetes mellitus |
| spellingShingle | Temidayo Abe Obiora Egbuche Joseph Igwe Opeyemi Jegede Bivek Wagle Titilope Olanipekun Anekwe Onwuanyi Cardiovascular complications in COVID‐19 patients with or without diabetes mellitus Endocrinology, Diabetes & Metabolism cardiovascular complications COVID‐19 diabetes mellitus |
| title | Cardiovascular complications in COVID‐19 patients with or without diabetes mellitus |
| title_full | Cardiovascular complications in COVID‐19 patients with or without diabetes mellitus |
| title_fullStr | Cardiovascular complications in COVID‐19 patients with or without diabetes mellitus |
| title_full_unstemmed | Cardiovascular complications in COVID‐19 patients with or without diabetes mellitus |
| title_short | Cardiovascular complications in COVID‐19 patients with or without diabetes mellitus |
| title_sort | cardiovascular complications in covid 19 patients with or without diabetes mellitus |
| topic | cardiovascular complications COVID‐19 diabetes mellitus |
| url | https://doi.org/10.1002/edm2.218 |
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