Analysis of TCR Repertoire and PD-1 Expression in Decidual and Peripheral CD8+ T Cells Reveals Distinct Immune Mechanisms in Miscarriage and Preeclampsia

Analysis of TCR Repertoire and PD-1 Expression in Decidual and Peripheral CD8+ T Cells Reveals Distinct Immune Mechanisms in Miscarriage and Preeclampsia

CD8+ T cells, the most abundant T cell subset in the decidua, play a critical role in the maintenance of pregnancy. The majority of decidual CD8+ T cells have an effector memory phenotype, while those in the peripheral blood display a naive phenotype. An increased amount of highly differentiated CD8...

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Bibliographic Details
Main Authors: Keiko Morita, Sayaka Tsuda, Eiji Kobayashi, Hiroshi Hamana, Kei Tsuda, Tomoko Shima, Akitoshi Nakashima, Akemi Ushijima, Hiroyuki Kishi, Shigeru Saito
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
effector memory CD8+ T cell
human pregnancy
miscarriage
preeclampsia
T cell repertoire
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01082/full

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