Cardiovascular Safety of Sodium Glucose Cotransporter 2 Inhibitors as Add-on to Metformin Monotherapy in Patients with Type 2 Diabetes Mellitus
Background Using real-world data, cardiovascular safety was investigated in metformin users newly starting sodium glucose cotransporter 2 (SGLT2) inhibitors compared with other glucose-lowering drugs in Korea. Methods This was a retrospective observational study using the National Health Insurance S...
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2021-07-01
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| Series: | Diabetes & Metabolism Journal |
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| Online Access: | http://www.e-dmj.org/upload/pdf/dmj-2020-0057.pdf |
| _version_ | 1818724217313558528 |
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| author | Ja Young Jeon Kyoung Hwa Ha Dae Jung Kim |
| author_facet | Ja Young Jeon Kyoung Hwa Ha Dae Jung Kim |
| author_sort | Ja Young Jeon |
| collection | DOAJ |
| description | Background Using real-world data, cardiovascular safety was investigated in metformin users newly starting sodium glucose cotransporter 2 (SGLT2) inhibitors compared with other glucose-lowering drugs in Korea. Methods This was a retrospective observational study using the National Health Insurance Service claims database in Korea. The study period was from September 2014 to December 2016. The study included subjects who were newly prescribed SGLT2 inhibitors or other glucose-lowering drugs while on metformin monotherapy; cohort 1 was composed of new users of SGLT2 inhibitors versus dipeptidyl peptidase-4 (DPP-4) inhibitors and cohort 2 included new users of SGLT2 inhibitors versus sulfonylureas. To balance the patient characteristics, propensity score matching was performed at a 1:1 ratio. Cardiovascular outcomes included hospitalization for heart failure (HHF), all-cause mortality, HHF plus all-cause mortality, myocardial infarction (MI), stroke, and modified major adverse cardiovascular events (MACEs). Results After propensity score matching, each cohort group was well balanced at baseline (21,688 pairs in cohort 1 and 20,120 pairs in cohort 2). As the second-line treatment, use of SGLT2 inhibitors was associated with a lower risk of HHF and HHF plus all-cause mortality compared with DPP-4 inhibitors. In addition, use of SGLT2 inhibitors versus sulfonylurea as add-on therapy to metformin was associated with decreased risks of HHF, all-cause mortality, HHF plus all-cause mortality, MI, stroke, and modified MACEs. Conclusion SGLT2 inhibitors can be a good second-line drug to reduce the incidence of cardiovascular diseases compared with DPP-4 inhibitors or sulfonylureas in people with type 2 diabetes mellitus. |
| first_indexed | 2024-12-17T21:22:54Z |
| format | Article |
| id | doaj.art-c398b38ffad34e149ff2c56b70c84292 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-17T21:22:54Z |
| publishDate | 2021-07-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-c398b38ffad34e149ff2c56b70c842922022-12-21T21:32:08ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872021-07-0145450551410.4093/dmj.2020.00571809Cardiovascular Safety of Sodium Glucose Cotransporter 2 Inhibitors as Add-on to Metformin Monotherapy in Patients with Type 2 Diabetes MellitusJa Young Jeon0Kyoung Hwa Ha1Dae Jung Kim2Department of Endocrinology and Metabolism, Ajou University Hospital, Ajou University School of Medicine, Suwon, KoreaDepartment of Endocrinology and Metabolism, Ajou University Hospital, Ajou University School of Medicine, Suwon, KoreaDepartment of Endocrinology and Metabolism, Ajou University Hospital, Ajou University School of Medicine, Suwon, KoreaBackground Using real-world data, cardiovascular safety was investigated in metformin users newly starting sodium glucose cotransporter 2 (SGLT2) inhibitors compared with other glucose-lowering drugs in Korea. Methods This was a retrospective observational study using the National Health Insurance Service claims database in Korea. The study period was from September 2014 to December 2016. The study included subjects who were newly prescribed SGLT2 inhibitors or other glucose-lowering drugs while on metformin monotherapy; cohort 1 was composed of new users of SGLT2 inhibitors versus dipeptidyl peptidase-4 (DPP-4) inhibitors and cohort 2 included new users of SGLT2 inhibitors versus sulfonylureas. To balance the patient characteristics, propensity score matching was performed at a 1:1 ratio. Cardiovascular outcomes included hospitalization for heart failure (HHF), all-cause mortality, HHF plus all-cause mortality, myocardial infarction (MI), stroke, and modified major adverse cardiovascular events (MACEs). Results After propensity score matching, each cohort group was well balanced at baseline (21,688 pairs in cohort 1 and 20,120 pairs in cohort 2). As the second-line treatment, use of SGLT2 inhibitors was associated with a lower risk of HHF and HHF plus all-cause mortality compared with DPP-4 inhibitors. In addition, use of SGLT2 inhibitors versus sulfonylurea as add-on therapy to metformin was associated with decreased risks of HHF, all-cause mortality, HHF plus all-cause mortality, MI, stroke, and modified MACEs. Conclusion SGLT2 inhibitors can be a good second-line drug to reduce the incidence of cardiovascular diseases compared with DPP-4 inhibitors or sulfonylureas in people with type 2 diabetes mellitus.http://www.e-dmj.org/upload/pdf/dmj-2020-0057.pdfdeathdiabetes mellitustype 2heart failuremyocardial infarctionretrospective studiessodium-glucose transporter 2 inhibitorsstroke |
| spellingShingle | Ja Young Jeon Kyoung Hwa Ha Dae Jung Kim Cardiovascular Safety of Sodium Glucose Cotransporter 2 Inhibitors as Add-on to Metformin Monotherapy in Patients with Type 2 Diabetes Mellitus Diabetes & Metabolism Journal death diabetes mellitus type 2 heart failure myocardial infarction retrospective studies sodium-glucose transporter 2 inhibitors stroke |
| title | Cardiovascular Safety of Sodium Glucose Cotransporter 2 Inhibitors as Add-on to Metformin Monotherapy in Patients with Type 2 Diabetes Mellitus |
| title_full | Cardiovascular Safety of Sodium Glucose Cotransporter 2 Inhibitors as Add-on to Metformin Monotherapy in Patients with Type 2 Diabetes Mellitus |
| title_fullStr | Cardiovascular Safety of Sodium Glucose Cotransporter 2 Inhibitors as Add-on to Metformin Monotherapy in Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Cardiovascular Safety of Sodium Glucose Cotransporter 2 Inhibitors as Add-on to Metformin Monotherapy in Patients with Type 2 Diabetes Mellitus |
| title_short | Cardiovascular Safety of Sodium Glucose Cotransporter 2 Inhibitors as Add-on to Metformin Monotherapy in Patients with Type 2 Diabetes Mellitus |
| title_sort | cardiovascular safety of sodium glucose cotransporter 2 inhibitors as add on to metformin monotherapy in patients with type 2 diabetes mellitus |
| topic | death diabetes mellitus type 2 heart failure myocardial infarction retrospective studies sodium-glucose transporter 2 inhibitors stroke |
| url | http://www.e-dmj.org/upload/pdf/dmj-2020-0057.pdf |
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