Characterization of novel PI3Kδ inhibitors as potential therapeutics for SLE and lupus nephritis in pre-clinical studies

Characterization of novel PI3Kδ inhibitors as potential therapeutics for SLE and lupus nephritis in pre-clinical studies

SLE is a complex autoimmune inflammatory disease characterized by pathogenic autoantibody production as a consequence of uncontrolled T-B cell activity and immune complex deposition in various organs, including kidney, leading to tissue damage and function loss. There is a high unmet need for better...

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Bibliographic Details
Main Authors: Philipp eHaselmayer, Montserrat eCamps, Mathilde eMuzerelle, Samer eEl Bawab, Caroline eWaltzinger, Lisa eBruns, Nada eAbla, Mark ePolokoff, Carole eJond-Necand, Marilène eGaudet, Audery eBenoit, Dominique eBertschy Meier, Catherine eMartin, Denise eGretener, Maria Stella Lombardi, Roland eGrenningloh, Christoph eLadel, Jørgen Søberg Petersen, Pascale eGaillard, Hong eJi
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Immunology
Subjects:
Lupus Nephritis
immune response
Drug Development
SLE
pharmacokinetic/pharmacodynamic modeling
PI3Kδ inhibitor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00233/full

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