Oral Ferrous Sulphate Improves Functional Capacity on Heart Failure Patients with Iron Deficiency Anemia
Background: Iron deficiency anemia (IDA) in heart failure (HF) is associated with poor functional capacity. Several studies reported the benefit of iron therapy in HF with IDA on improving functional capacity. Therefore, we attempt to investigate the effect of oral iron supplementation on functional...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Ubiquity Press
2022-11-01
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| Series: | Global Heart |
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| Online Access: | https://globalheartjournal.com/articles/1151 |
| _version_ | 1811199280993533952 |
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| author | Lita Dwi Suryani Sunu Budhi Raharjo Rima Sagita Hansen Angkasa Yosafat Lambang Prasetyadi Franciscus D. Suyatna Nani Hersunarti Rarsari Soerarso Bambang Budi Siswanto Hary Sakti Muliawan |
| author_facet | Lita Dwi Suryani Sunu Budhi Raharjo Rima Sagita Hansen Angkasa Yosafat Lambang Prasetyadi Franciscus D. Suyatna Nani Hersunarti Rarsari Soerarso Bambang Budi Siswanto Hary Sakti Muliawan |
| author_sort | Lita Dwi Suryani |
| collection | DOAJ |
| description | Background: Iron deficiency anemia (IDA) in heart failure (HF) is associated with poor functional capacity. Several studies reported the benefit of iron therapy in HF with IDA on improving functional capacity. Therefore, we attempt to investigate the effect of oral iron supplementation on functional capacity in HF patients with IDA. Results: Double blind randomized controlled trial was conducted in National Cardiovascular Center Harapan Kita Hospital Universitas Indonesia. A total 54 HFREF patients with IDA were enrolled and randomized to either oral Ferrous Sulphate (FS) 200mg 3 times a day or placebo with 1:1 ratio for 12 weeks. Primary outcome was functional capacity measured by 6-minute walk test. There were 41 participants completed the study (FS n=22, placebo n=19). Ferrous sulphate significantly improved functional capacity changes (46.23+35m vs -13.7+46m, p<0.001, CI -86.8 to -33.2) compared with placebo groups respectively after 12 weeks intervention. Conclusions: Oral FS supplementation for 12 weeks significantly improved functional capacity in HF patients with IDA. Trial registration: clinicaltrials.gov, NCT02998697. Registered 14 December 2016 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02998697 |
| first_indexed | 2024-04-12T01:45:16Z |
| format | Article |
| id | doaj.art-c39b13a753014fa7b85ebd0a53c9141c |
| institution | Directory Open Access Journal |
| issn | 2211-8179 |
| language | English |
| last_indexed | 2024-04-12T01:45:16Z |
| publishDate | 2022-11-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Global Heart |
| spelling | doaj.art-c39b13a753014fa7b85ebd0a53c9141c2022-12-22T03:53:06ZengUbiquity PressGlobal Heart2211-81792022-11-0117110.5334/gh.1151989Oral Ferrous Sulphate Improves Functional Capacity on Heart Failure Patients with Iron Deficiency AnemiaLita Dwi Suryani0Sunu Budhi Raharjo1Rima Sagita2Hansen Angkasa3Yosafat Lambang Prasetyadi4Franciscus D. Suyatna5Nani Hersunarti6Rarsari Soerarso7Bambang Budi Siswanto8Hary Sakti Muliawan9Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita Hospital, Indonesia/Universitas Indonesia HospitalDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita Hospital, Indonesia/Universitas Indonesia HospitalDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita Hospital, Indonesia/Universitas Indonesia HospitalDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita Hospital, Indonesia/Universitas Indonesia HospitalDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita Hospital, Indonesia/Universitas Indonesia HospitalDepartment of Pharmacology and Therapeutic, Faculty of Medicine, Universitas IndonesiaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/NationaINCardiovascular Center Harapan Kita Hospital, Indonesia/Universitas Indonesia HospitalDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita Hospital, Indonesia/Universitas Indonesia HospitalDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita Hospital, Indonesia/Universitas Indonesia HospitalDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita Hospital, Indonesia/Universitas Indonesia HospitalBackground: Iron deficiency anemia (IDA) in heart failure (HF) is associated with poor functional capacity. Several studies reported the benefit of iron therapy in HF with IDA on improving functional capacity. Therefore, we attempt to investigate the effect of oral iron supplementation on functional capacity in HF patients with IDA. Results: Double blind randomized controlled trial was conducted in National Cardiovascular Center Harapan Kita Hospital Universitas Indonesia. A total 54 HFREF patients with IDA were enrolled and randomized to either oral Ferrous Sulphate (FS) 200mg 3 times a day or placebo with 1:1 ratio for 12 weeks. Primary outcome was functional capacity measured by 6-minute walk test. There were 41 participants completed the study (FS n=22, placebo n=19). Ferrous sulphate significantly improved functional capacity changes (46.23+35m vs -13.7+46m, p<0.001, CI -86.8 to -33.2) compared with placebo groups respectively after 12 weeks intervention. Conclusions: Oral FS supplementation for 12 weeks significantly improved functional capacity in HF patients with IDA. Trial registration: clinicaltrials.gov, NCT02998697. Registered 14 December 2016 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02998697https://globalheartjournal.com/articles/1151heart failure, iron heart failureiron deficiency anemiaoral ferrous sulphatefunctional capacityanemia, oral ferrous sulphate, functional capacity |
| spellingShingle | Lita Dwi Suryani Sunu Budhi Raharjo Rima Sagita Hansen Angkasa Yosafat Lambang Prasetyadi Franciscus D. Suyatna Nani Hersunarti Rarsari Soerarso Bambang Budi Siswanto Hary Sakti Muliawan Oral Ferrous Sulphate Improves Functional Capacity on Heart Failure Patients with Iron Deficiency Anemia Global Heart heart failure, iron heart failure iron deficiency anemia oral ferrous sulphate functional capacityanemia, oral ferrous sulphate, functional capacity |
| title | Oral Ferrous Sulphate Improves Functional Capacity on Heart Failure Patients with Iron Deficiency Anemia |
| title_full | Oral Ferrous Sulphate Improves Functional Capacity on Heart Failure Patients with Iron Deficiency Anemia |
| title_fullStr | Oral Ferrous Sulphate Improves Functional Capacity on Heart Failure Patients with Iron Deficiency Anemia |
| title_full_unstemmed | Oral Ferrous Sulphate Improves Functional Capacity on Heart Failure Patients with Iron Deficiency Anemia |
| title_short | Oral Ferrous Sulphate Improves Functional Capacity on Heart Failure Patients with Iron Deficiency Anemia |
| title_sort | oral ferrous sulphate improves functional capacity on heart failure patients with iron deficiency anemia |
| topic | heart failure, iron heart failure iron deficiency anemia oral ferrous sulphate functional capacityanemia, oral ferrous sulphate, functional capacity |
| url | https://globalheartjournal.com/articles/1151 |
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