CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray.
Systemic inflammation like in sepsis is still lacking specific diagnostic markers and effective therapeutics. The first line of defense against intruding pathogens and endogenous damage signals is pattern recognition by e.g., complement and Toll-like receptors (TLR). Combined inhibition of a key com...
| Main Authors: | , , , , , , , , , |
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| פורמט: | Article |
| שפה: | English |
| יצא לאור: |
Public Library of Science (PLoS)
2015-01-01
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| סדרה: | PLoS ONE |
| גישה מקוונת: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117261&type=printable |