P3.1 SUB-MAXIMAL EXERCISE BLOOD PRESSURE RELATES TO LEFT VENTRICULAR MASS INDEX, BUT IS DEPENDENT ON LOW AEROBIC CAPACITY
Background: Exaggerated blood pressure (BP) responses to sub-maximal exercise independently predict cardiovascular (CV) events, mortality and incident hypertension. The aim of this study was to explore relationships between exercise BP, left-ventricular (LV) structure and function and aerobic fitnes...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2015-11-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125930589/view |
| _version_ | 1828330735647326208 |
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| author | Martin Schultz* Dean Picone Rachel Climie Costan Magnussen Leah Wright Thomas Marwick Alison Venn James Sharman |
| author_facet | Martin Schultz* Dean Picone Rachel Climie Costan Magnussen Leah Wright Thomas Marwick Alison Venn James Sharman |
| author_sort | Martin Schultz* |
| collection | DOAJ |
| description | Background: Exaggerated blood pressure (BP) responses to sub-maximal exercise independently predict cardiovascular (CV) events, mortality and incident hypertension. The aim of this study was to explore relationships between exercise BP, left-ventricular (LV) structure and function and aerobic fitness as potential mechanisms underlying the CV risk associated with sub-maximal exercise BP.
Methods: 149 participants aged 40±2 years, 45% male completed a staged cycle test to estimate physical work capacity (aerobic fitness; PWC170) with concomitant BP measured each two minutes. 2D echocardiography was used to quantify LV mass (obtained from 2D-guided M-mode echo), and LV function (longitudinal strain, haemodynamics).
Results: Early-stage exercise systolic BP was associated with aerobic fitness and LV mass index (r=0.22, and 0.24, p<0.05) and was greater in those performing high stage-relative work (high-fitness) compared with low stage-relative work (low-fitness) (154±22 vs. 133±15 mmHg, p<0.001). The high-fitness group had greater stroke volume, lower heart rate and LV longitudinal strain compared to the low-fitness group (72±18 vs. 59±15 ml, 61±9 vs. 68±9 bpm, −18±4 vs. −20±3%, p<0.05 for all). Exercise systolic BP was associated with LV mass index independent of resting BP, age and sex in the low-fitness group during stage one of the PWC170 (β=0.13, 95% CI=0.01-0.3) but not in the high-fitness group at any stage.
Conclusions: Sub-maximal exercise systolic BP independently relates to LV mass index in those with low, early stage-relative aerobic capacity. BP measured during submaximal exercise testing (light-intensity) may reveal early changes in hypertension-related organ damage that are more evident in people with low-fitness. |
| first_indexed | 2024-04-13T20:42:50Z |
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| id | doaj.art-c39e8b51ccf64a8eb440edf8241898cc |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-04-13T20:42:50Z |
| publishDate | 2015-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-c39e8b51ccf64a8eb440edf8241898cc2022-12-22T02:30:48ZengBMCArtery Research1876-44012015-11-011210.1016/j.artres.2015.10.226P3.1 SUB-MAXIMAL EXERCISE BLOOD PRESSURE RELATES TO LEFT VENTRICULAR MASS INDEX, BUT IS DEPENDENT ON LOW AEROBIC CAPACITYMartin Schultz*Dean PiconeRachel ClimieCostan MagnussenLeah WrightThomas MarwickAlison VennJames SharmanBackground: Exaggerated blood pressure (BP) responses to sub-maximal exercise independently predict cardiovascular (CV) events, mortality and incident hypertension. The aim of this study was to explore relationships between exercise BP, left-ventricular (LV) structure and function and aerobic fitness as potential mechanisms underlying the CV risk associated with sub-maximal exercise BP. Methods: 149 participants aged 40±2 years, 45% male completed a staged cycle test to estimate physical work capacity (aerobic fitness; PWC170) with concomitant BP measured each two minutes. 2D echocardiography was used to quantify LV mass (obtained from 2D-guided M-mode echo), and LV function (longitudinal strain, haemodynamics). Results: Early-stage exercise systolic BP was associated with aerobic fitness and LV mass index (r=0.22, and 0.24, p<0.05) and was greater in those performing high stage-relative work (high-fitness) compared with low stage-relative work (low-fitness) (154±22 vs. 133±15 mmHg, p<0.001). The high-fitness group had greater stroke volume, lower heart rate and LV longitudinal strain compared to the low-fitness group (72±18 vs. 59±15 ml, 61±9 vs. 68±9 bpm, −18±4 vs. −20±3%, p<0.05 for all). Exercise systolic BP was associated with LV mass index independent of resting BP, age and sex in the low-fitness group during stage one of the PWC170 (β=0.13, 95% CI=0.01-0.3) but not in the high-fitness group at any stage. Conclusions: Sub-maximal exercise systolic BP independently relates to LV mass index in those with low, early stage-relative aerobic capacity. BP measured during submaximal exercise testing (light-intensity) may reveal early changes in hypertension-related organ damage that are more evident in people with low-fitness.https://www.atlantis-press.com/article/125930589/view |
| spellingShingle | Martin Schultz* Dean Picone Rachel Climie Costan Magnussen Leah Wright Thomas Marwick Alison Venn James Sharman P3.1 SUB-MAXIMAL EXERCISE BLOOD PRESSURE RELATES TO LEFT VENTRICULAR MASS INDEX, BUT IS DEPENDENT ON LOW AEROBIC CAPACITY Artery Research |
| title | P3.1 SUB-MAXIMAL EXERCISE BLOOD PRESSURE RELATES TO LEFT VENTRICULAR MASS INDEX, BUT IS DEPENDENT ON LOW AEROBIC CAPACITY |
| title_full | P3.1 SUB-MAXIMAL EXERCISE BLOOD PRESSURE RELATES TO LEFT VENTRICULAR MASS INDEX, BUT IS DEPENDENT ON LOW AEROBIC CAPACITY |
| title_fullStr | P3.1 SUB-MAXIMAL EXERCISE BLOOD PRESSURE RELATES TO LEFT VENTRICULAR MASS INDEX, BUT IS DEPENDENT ON LOW AEROBIC CAPACITY |
| title_full_unstemmed | P3.1 SUB-MAXIMAL EXERCISE BLOOD PRESSURE RELATES TO LEFT VENTRICULAR MASS INDEX, BUT IS DEPENDENT ON LOW AEROBIC CAPACITY |
| title_short | P3.1 SUB-MAXIMAL EXERCISE BLOOD PRESSURE RELATES TO LEFT VENTRICULAR MASS INDEX, BUT IS DEPENDENT ON LOW AEROBIC CAPACITY |
| title_sort | p3 1 sub maximal exercise blood pressure relates to left ventricular mass index but is dependent on low aerobic capacity |
| url | https://www.atlantis-press.com/article/125930589/view |
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