Acanthamoeba castellanii STAT protein.
STAT (signal transducers and activators of transcription) proteins are one of the important mediators of phosphotyrosine-regulated signaling in metazoan cells. We described the presence of STAT protein in a unicellular, free-living amoebae with a simple life cycle, Acanthamoeba castellanii. A. caste...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4206453?pdf=render |
| _version_ | 1818925020056911872 |
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| author | Anna Kicinska Jacek Leluk Wieslawa Jarmuszkiewicz |
| author_facet | Anna Kicinska Jacek Leluk Wieslawa Jarmuszkiewicz |
| author_sort | Anna Kicinska |
| collection | DOAJ |
| description | STAT (signal transducers and activators of transcription) proteins are one of the important mediators of phosphotyrosine-regulated signaling in metazoan cells. We described the presence of STAT protein in a unicellular, free-living amoebae with a simple life cycle, Acanthamoeba castellanii. A. castellanii is the only, studied to date, Amoebozoan that does not belong to Mycetozoa but possesses STATs. A sequence of the A. castellanii STAT protein includes domains similar to those of the Dictyostelium STAT proteins: a coiled coil (characteristic for Dictyostelium STAT coiled coil), a STAT DNA-binding domain and a Src-homology domain. The search for protein sequences homologous to A. castellanii STAT revealed 17 additional sequences from lower eukaryotes. Interestingly, all of these sequences come from Amoebozoa organisms that belong to either Mycetozoa (slime molds) or Centramoebida. We showed that there are four separated clades within the slime mold STAT proteins. The A. castellanii STAT protein branches next to a group of STATc proteins from Mycetozoa. We also demonstrate that Amoebozoa form a distinct monophyletic lineage within the STAT protein world that is well separated from the other groups. |
| first_indexed | 2024-12-20T02:34:35Z |
| format | Article |
| id | doaj.art-c39ee3c262e1446db62ff9bea3429c40 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T02:34:35Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c39ee3c262e1446db62ff9bea3429c402022-12-21T19:56:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01910e11134510.1371/journal.pone.0111345Acanthamoeba castellanii STAT protein.Anna KicinskaJacek LelukWieslawa JarmuszkiewiczSTAT (signal transducers and activators of transcription) proteins are one of the important mediators of phosphotyrosine-regulated signaling in metazoan cells. We described the presence of STAT protein in a unicellular, free-living amoebae with a simple life cycle, Acanthamoeba castellanii. A. castellanii is the only, studied to date, Amoebozoan that does not belong to Mycetozoa but possesses STATs. A sequence of the A. castellanii STAT protein includes domains similar to those of the Dictyostelium STAT proteins: a coiled coil (characteristic for Dictyostelium STAT coiled coil), a STAT DNA-binding domain and a Src-homology domain. The search for protein sequences homologous to A. castellanii STAT revealed 17 additional sequences from lower eukaryotes. Interestingly, all of these sequences come from Amoebozoa organisms that belong to either Mycetozoa (slime molds) or Centramoebida. We showed that there are four separated clades within the slime mold STAT proteins. The A. castellanii STAT protein branches next to a group of STATc proteins from Mycetozoa. We also demonstrate that Amoebozoa form a distinct monophyletic lineage within the STAT protein world that is well separated from the other groups.http://europepmc.org/articles/PMC4206453?pdf=render |
| spellingShingle | Anna Kicinska Jacek Leluk Wieslawa Jarmuszkiewicz Acanthamoeba castellanii STAT protein. PLoS ONE |
| title | Acanthamoeba castellanii STAT protein. |
| title_full | Acanthamoeba castellanii STAT protein. |
| title_fullStr | Acanthamoeba castellanii STAT protein. |
| title_full_unstemmed | Acanthamoeba castellanii STAT protein. |
| title_short | Acanthamoeba castellanii STAT protein. |
| title_sort | acanthamoeba castellanii stat protein |
| url | http://europepmc.org/articles/PMC4206453?pdf=render |
| work_keys_str_mv | AT annakicinska acanthamoebacastellaniistatprotein AT jacekleluk acanthamoebacastellaniistatprotein AT wieslawajarmuszkiewicz acanthamoebacastellaniistatprotein |