Typical asymmetry in the hemispheric activation during an fMRI verbal comprehension paradigm is related to better performance in verbal and non-verbal tasks in patients with epilepsy
Chronic exposure to seizures in patients with left hemisphere (LH) epileptic focus could favor higher activation in the contralateral hemisphere during language processing, but the cognitive effects of this remain unclear. This study assesses the relationship between asymmetry in hemispheric activat...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218302857 |
| _version_ | 1818876333582712832 |
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| author | Irene Cano-López Anna Calvo Teresa Boget Mar Carreño Antonio Donaire Xavier Setoain Luis Pintor Jordi Rumià Esperanza González-Bono Carme Junqué Núria Bargalló Liam Mason |
| author_facet | Irene Cano-López Anna Calvo Teresa Boget Mar Carreño Antonio Donaire Xavier Setoain Luis Pintor Jordi Rumià Esperanza González-Bono Carme Junqué Núria Bargalló Liam Mason |
| author_sort | Irene Cano-López |
| collection | DOAJ |
| description | Chronic exposure to seizures in patients with left hemisphere (LH) epileptic focus could favor higher activation in the contralateral hemisphere during language processing, but the cognitive effects of this remain unclear. This study assesses the relationship between asymmetry in hemispheric activation during language fMRI and performance in verbal and non-verbal tasks. Whereas prior studies primarily used fMRI paradigms that favor frontal lobe activation and less prominent activation of the medial or superior temporal lobes, we used a verbal comprehension paradigm previously demonstrated to activate reliably receptive language areas. Forty-seven patients with drug-resistant epilepsy candidates for surgery underwent a multidisciplinary assessment, including a comprehensive neuropsychological evaluation and an fMRI verbal comprehension paradigm. Patients were distributed in two groups depending on laterality indexes (LI): typical hemispheric asymmetry (unilateral left activation preponderance; n = 23) and atypical hemispheric asymmetry (bilateral or unilateral right preponderance; n = 24). Right-handedness and right hemisphere (RH) focus were significant predictors of typical asymmetry. Patients with typical activation pattern presented better performance intelligence quotient and verbal learning than patients with atypical hemispheric asymmetry (for all, p < 0.014). Patients with LH focus had more frequently atypical hemispheric asymmetry than patients with RH focus (p = 0.05). Specifically, they showed lower LI and this was related to worse performance in verbal and non-verbal tasks. In conclusion, an increased activation of homologous RH areas for verbal comprehension processing could imply a competition of cognitive resources in the performance of the same task, disrupting cognitive performance. Keywords: Typical asymmetry, Language, fMRI, Epilepsy, Cognitive performance |
| first_indexed | 2024-12-19T13:40:44Z |
| format | Article |
| id | doaj.art-c39fa444c0c14e83bf74983a823a62a0 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-19T13:40:44Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-c39fa444c0c14e83bf74983a823a62a02022-12-21T20:19:02ZengElsevierNeuroImage: Clinical2213-15822018-01-0120742752Typical asymmetry in the hemispheric activation during an fMRI verbal comprehension paradigm is related to better performance in verbal and non-verbal tasks in patients with epilepsyIrene Cano-López0Anna Calvo1Teresa Boget2Mar Carreño3Antonio Donaire4Xavier Setoain5Luis Pintor6Jordi Rumià7Esperanza González-Bono8Carme Junqué9Núria Bargalló10Liam Mason11IDOCAL/Department of Psychobiology, Psychology Center, University of Valencia, Valencia, Spain; Corresponding author at: IDOCAL/Department of Psychobiology, Psychology Center, University of Valencia, Avda. Blasco Ibañez, 21, 46010, Valencia, Spain.IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, SpainEpilepsy Unit, Department of Psychiatry, Hospital Clínic, Barcelona, SpainEpilepsy Unit, Department of Neurology, Hospital Clínic, Barcelona, SpainEpilepsy Unit, Department of Neurology, Hospital Clínic, Barcelona, SpainEpilepsy Unit, Department of Nuclear Medicine, Hospital Clínic, Barcelona, Spain; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, SpainEpilepsy Unit, Department of Psychiatry, Hospital Clínic, Barcelona, SpainEpilepsy Unit, Department of Neurosurgery, Hospital Clínic, Barcelona, SpainIDOCAL/Department of Psychobiology, Psychology Center, University of Valencia, Valencia, SpainIDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain; Medical Psychology Unit, Department of Medicine, Institute of Neuroscience, University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, Barcelona, SpainIDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain; Epilepsy Unit, Department of Radiology, Hospital Clínic, Barcelona, SpainUniversity College London, Research Department of Clinical, Educational and Health Psychology, London UKChronic exposure to seizures in patients with left hemisphere (LH) epileptic focus could favor higher activation in the contralateral hemisphere during language processing, but the cognitive effects of this remain unclear. This study assesses the relationship between asymmetry in hemispheric activation during language fMRI and performance in verbal and non-verbal tasks. Whereas prior studies primarily used fMRI paradigms that favor frontal lobe activation and less prominent activation of the medial or superior temporal lobes, we used a verbal comprehension paradigm previously demonstrated to activate reliably receptive language areas. Forty-seven patients with drug-resistant epilepsy candidates for surgery underwent a multidisciplinary assessment, including a comprehensive neuropsychological evaluation and an fMRI verbal comprehension paradigm. Patients were distributed in two groups depending on laterality indexes (LI): typical hemispheric asymmetry (unilateral left activation preponderance; n = 23) and atypical hemispheric asymmetry (bilateral or unilateral right preponderance; n = 24). Right-handedness and right hemisphere (RH) focus were significant predictors of typical asymmetry. Patients with typical activation pattern presented better performance intelligence quotient and verbal learning than patients with atypical hemispheric asymmetry (for all, p < 0.014). Patients with LH focus had more frequently atypical hemispheric asymmetry than patients with RH focus (p = 0.05). Specifically, they showed lower LI and this was related to worse performance in verbal and non-verbal tasks. In conclusion, an increased activation of homologous RH areas for verbal comprehension processing could imply a competition of cognitive resources in the performance of the same task, disrupting cognitive performance. Keywords: Typical asymmetry, Language, fMRI, Epilepsy, Cognitive performancehttp://www.sciencedirect.com/science/article/pii/S2213158218302857 |
| spellingShingle | Irene Cano-López Anna Calvo Teresa Boget Mar Carreño Antonio Donaire Xavier Setoain Luis Pintor Jordi Rumià Esperanza González-Bono Carme Junqué Núria Bargalló Liam Mason Typical asymmetry in the hemispheric activation during an fMRI verbal comprehension paradigm is related to better performance in verbal and non-verbal tasks in patients with epilepsy NeuroImage: Clinical |
| title | Typical asymmetry in the hemispheric activation during an fMRI verbal comprehension paradigm is related to better performance in verbal and non-verbal tasks in patients with epilepsy |
| title_full | Typical asymmetry in the hemispheric activation during an fMRI verbal comprehension paradigm is related to better performance in verbal and non-verbal tasks in patients with epilepsy |
| title_fullStr | Typical asymmetry in the hemispheric activation during an fMRI verbal comprehension paradigm is related to better performance in verbal and non-verbal tasks in patients with epilepsy |
| title_full_unstemmed | Typical asymmetry in the hemispheric activation during an fMRI verbal comprehension paradigm is related to better performance in verbal and non-verbal tasks in patients with epilepsy |
| title_short | Typical asymmetry in the hemispheric activation during an fMRI verbal comprehension paradigm is related to better performance in verbal and non-verbal tasks in patients with epilepsy |
| title_sort | typical asymmetry in the hemispheric activation during an fmri verbal comprehension paradigm is related to better performance in verbal and non verbal tasks in patients with epilepsy |
| url | http://www.sciencedirect.com/science/article/pii/S2213158218302857 |
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