Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance
Pancreatic cancer is one of the most deadly cancers, ranking amongst the top leading cause of cancer related deaths in developed countries. Features such as dense stroma microenvironment, abnormal signaling pathways, and genetic heterogeneity of the tumors contribute to its chemoresistant character...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.683788/full |
| _version_ | 1830429904147054592 |
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| author | Ntombikayise Xelwa Geoffrey Patrick Candy John Devar Jones Omoshoro-Jones Martin Smith Ekene Emmanuel Nweke |
| author_facet | Ntombikayise Xelwa Geoffrey Patrick Candy John Devar Jones Omoshoro-Jones Martin Smith Ekene Emmanuel Nweke |
| author_sort | Ntombikayise Xelwa |
| collection | DOAJ |
| description | Pancreatic cancer is one of the most deadly cancers, ranking amongst the top leading cause of cancer related deaths in developed countries. Features such as dense stroma microenvironment, abnormal signaling pathways, and genetic heterogeneity of the tumors contribute to its chemoresistant characteristics. Amongst these features, growth factors have been observed to play crucial roles in cancer cell survival, progression, and chemoresistance. Here we review the role of the individual growth factors in pancreatic cancer chemoresistance. Importantly, the interplay between the tumor microenvironment and chemoresistance is explored in the context of pivotal role played by growth factors. We further describe current and future potential therapeutic targeting of these factors. |
| first_indexed | 2024-12-21T01:41:34Z |
| format | Article |
| id | doaj.art-c3a05274f9954a05b10e9e73e50e4db4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T01:41:34Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c3a05274f9954a05b10e9e73e50e4db42022-12-21T19:20:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-06-011110.3389/fonc.2021.683788683788Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting ChemoresistanceNtombikayise XelwaGeoffrey Patrick CandyJohn DevarJones Omoshoro-JonesMartin SmithEkene Emmanuel NwekePancreatic cancer is one of the most deadly cancers, ranking amongst the top leading cause of cancer related deaths in developed countries. Features such as dense stroma microenvironment, abnormal signaling pathways, and genetic heterogeneity of the tumors contribute to its chemoresistant characteristics. Amongst these features, growth factors have been observed to play crucial roles in cancer cell survival, progression, and chemoresistance. Here we review the role of the individual growth factors in pancreatic cancer chemoresistance. Importantly, the interplay between the tumor microenvironment and chemoresistance is explored in the context of pivotal role played by growth factors. We further describe current and future potential therapeutic targeting of these factors.https://www.frontiersin.org/articles/10.3389/fonc.2021.683788/fullpancreatic cancerchemoresistancegrowth factorschemotherapysignaling pathways |
| spellingShingle | Ntombikayise Xelwa Geoffrey Patrick Candy John Devar Jones Omoshoro-Jones Martin Smith Ekene Emmanuel Nweke Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance Frontiers in Oncology pancreatic cancer chemoresistance growth factors chemotherapy signaling pathways |
| title | Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance |
| title_full | Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance |
| title_fullStr | Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance |
| title_full_unstemmed | Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance |
| title_short | Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance |
| title_sort | targeting growth factor signaling pathways in pancreatic cancer towards inhibiting chemoresistance |
| topic | pancreatic cancer chemoresistance growth factors chemotherapy signaling pathways |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.683788/full |
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