Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria
A library of six compounds with new hybrids in a single molecule triazole ring attached to the phosphonium salts was synthesized. Click chemistry was, however, used to synthesize the 1-, 2-, and 3-triazole intermediates as a tether for the hybrid phosphonium salts. Their antibacterial activity again...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi-Wiley
2022-01-01
|
| Series: | Heteroatom Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2022/7411957 |
| _version_ | 1798020898816524288 |
|---|---|
| author | Cedric Dzidzor Kodjo Amengor Cynthia Amaning Danquah Emmanuel Bentil Asare Adusei Francis Klenam Kekessie Francis Ofosu-Koranteng Paul Peprah Benjamin Kingsley Harley Emmanuel Orman Joseph Adu Yussif Saaka |
| author_facet | Cedric Dzidzor Kodjo Amengor Cynthia Amaning Danquah Emmanuel Bentil Asare Adusei Francis Klenam Kekessie Francis Ofosu-Koranteng Paul Peprah Benjamin Kingsley Harley Emmanuel Orman Joseph Adu Yussif Saaka |
| author_sort | Cedric Dzidzor Kodjo Amengor |
| collection | DOAJ |
| description | A library of six compounds with new hybrids in a single molecule triazole ring attached to the phosphonium salts was synthesized. Click chemistry was, however, used to synthesize the 1-, 2-, and 3-triazole intermediates as a tether for the hybrid phosphonium salts. Their antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Enterococcus faecalis), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and Mycobacterium smegmatis mc2155 was determined using the HT-SPOTi assay. Compound 2 showed the most effective antimicrobial activity as it inhibited the growth of Pseudomonas aeruginosa and Staphylococcus aureus at 0.0125 µg/mL and 31.25 µg/mL, respectively. From the FICI data, compounds 2ET-TOL (2) and RABYL-TOL (4) successfully modulated the activities of amoxicillin against Pseudomonas aeruginosa and Staphylococcus aureus. All the test compounds exhibited a concentration-dependent biofilm formation inhibition against S. aureus, except P-Z (compound 6). Compounds P-MEOXY (1) and 2ET-TOL (2) exhibited mild activity against P. aeruginosa with compound 4 showing antimycobacterial activity at 500 µg/mL. |
| first_indexed | 2024-04-11T17:05:10Z |
| format | Article |
| id | doaj.art-c3a13e8d02654d62b042d9f2245e90a0 |
| institution | Directory Open Access Journal |
| issn | 1098-1071 |
| language | English |
| last_indexed | 2024-04-11T17:05:10Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi-Wiley |
| record_format | Article |
| series | Heteroatom Chemistry |
| spelling | doaj.art-c3a13e8d02654d62b042d9f2245e90a02022-12-22T04:13:04ZengHindawi-WileyHeteroatom Chemistry1098-10712022-01-01202210.1155/2022/7411957Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic BacteriaCedric Dzidzor Kodjo Amengor0Cynthia Amaning Danquah1Emmanuel Bentil Asare Adusei2Francis Klenam Kekessie3Francis Ofosu-Koranteng4Paul Peprah5Benjamin Kingsley Harley6Emmanuel Orman7Joseph Adu8Yussif Saaka9Department of Pharmaceutical ChemistryDepartment of PharmacologyDepartment of Pharmaceutical ChemistryDepartment of Pharmaceutical ChemistryAnalytical LaboratoryDepartment of Pharmaceutical ChemistryDepartment of Pharmacognosy and Herbal MedicineDepartment of Pharmaceutical ChemistryDepartment of Pharmaceutical ChemistryDepartment of PharmaceuticsA library of six compounds with new hybrids in a single molecule triazole ring attached to the phosphonium salts was synthesized. Click chemistry was, however, used to synthesize the 1-, 2-, and 3-triazole intermediates as a tether for the hybrid phosphonium salts. Their antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Enterococcus faecalis), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and Mycobacterium smegmatis mc2155 was determined using the HT-SPOTi assay. Compound 2 showed the most effective antimicrobial activity as it inhibited the growth of Pseudomonas aeruginosa and Staphylococcus aureus at 0.0125 µg/mL and 31.25 µg/mL, respectively. From the FICI data, compounds 2ET-TOL (2) and RABYL-TOL (4) successfully modulated the activities of amoxicillin against Pseudomonas aeruginosa and Staphylococcus aureus. All the test compounds exhibited a concentration-dependent biofilm formation inhibition against S. aureus, except P-Z (compound 6). Compounds P-MEOXY (1) and 2ET-TOL (2) exhibited mild activity against P. aeruginosa with compound 4 showing antimycobacterial activity at 500 µg/mL.http://dx.doi.org/10.1155/2022/7411957 |
| spellingShingle | Cedric Dzidzor Kodjo Amengor Cynthia Amaning Danquah Emmanuel Bentil Asare Adusei Francis Klenam Kekessie Francis Ofosu-Koranteng Paul Peprah Benjamin Kingsley Harley Emmanuel Orman Joseph Adu Yussif Saaka Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria Heteroatom Chemistry |
| title | Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria |
| title_full | Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria |
| title_fullStr | Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria |
| title_full_unstemmed | Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria |
| title_short | Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria |
| title_sort | synthesized phosphonium compounds demonstrate resistant modulatory and antibiofilm formation activities against some pathogenic bacteria |
| url | http://dx.doi.org/10.1155/2022/7411957 |
| work_keys_str_mv | AT cedricdzidzorkodjoamengor synthesizedphosphoniumcompoundsdemonstrateresistantmodulatoryandantibiofilmformationactivitiesagainstsomepathogenicbacteria AT cynthiaamaningdanquah synthesizedphosphoniumcompoundsdemonstrateresistantmodulatoryandantibiofilmformationactivitiesagainstsomepathogenicbacteria AT emmanuelbentilasareadusei synthesizedphosphoniumcompoundsdemonstrateresistantmodulatoryandantibiofilmformationactivitiesagainstsomepathogenicbacteria AT francisklenamkekessie synthesizedphosphoniumcompoundsdemonstrateresistantmodulatoryandantibiofilmformationactivitiesagainstsomepathogenicbacteria AT francisofosukoranteng synthesizedphosphoniumcompoundsdemonstrateresistantmodulatoryandantibiofilmformationactivitiesagainstsomepathogenicbacteria AT paulpeprah synthesizedphosphoniumcompoundsdemonstrateresistantmodulatoryandantibiofilmformationactivitiesagainstsomepathogenicbacteria AT benjaminkingsleyharley synthesizedphosphoniumcompoundsdemonstrateresistantmodulatoryandantibiofilmformationactivitiesagainstsomepathogenicbacteria AT emmanuelorman synthesizedphosphoniumcompoundsdemonstrateresistantmodulatoryandantibiofilmformationactivitiesagainstsomepathogenicbacteria AT josephadu synthesizedphosphoniumcompoundsdemonstrateresistantmodulatoryandantibiofilmformationactivitiesagainstsomepathogenicbacteria AT yussifsaaka synthesizedphosphoniumcompoundsdemonstrateresistantmodulatoryandantibiofilmformationactivitiesagainstsomepathogenicbacteria |