Serotonin syndrome triggered by postoperative administration of serotonin noradrenaline reuptake inhibitor (SNRI)
Abstract Background Serotonin syndrome is a rare but potentially severe disease, which is caused by hyperstimulation of serotonin receptors in the central nervous system. Several antidepressants exert their effect by modulating intrasynaptic serotonin concentration and anesthetics may affect the met...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-08-01
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| Series: | JA Clinical Reports |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40981-019-0275-5 |
| _version_ | 1818620766301716480 |
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| author | Junko Takata Tomoko Arashi Ayako Abe Shoko Arai Naoko Haruyama |
| author_facet | Junko Takata Tomoko Arashi Ayako Abe Shoko Arai Naoko Haruyama |
| author_sort | Junko Takata |
| collection | DOAJ |
| description | Abstract Background Serotonin syndrome is a rare but potentially severe disease, which is caused by hyperstimulation of serotonin receptors in the central nervous system. Several antidepressants exert their effect by modulating intrasynaptic serotonin concentration and anesthetics may affect the metabolism of serotonin, implicating to induce serotonin syndrome in patients taking those antidepressants. We present a case which provoked serotonin syndrome immediately after taking serotonin noradrenaline reuptake inhibitor (SNRI) in the postoperative period. Case presentation A 31-year-old female underwent laparoscopic ovarian cystectomy under general anesthesia with propofol, fentanyl, and remifentanil. She has been taking duloxetine, a SNRI for depression. She developed myoclonus seizure with an increase of blood pressure and heart rate after taking duloxetine on the day after the surgery, which was subsided by a non-selective serotonin receptor antagonist. Conclusions Anesthesiologists should be aware of the risk of perioperative serotonin syndrome in patients taking antidepressants affecting serotonin metabolism. |
| first_indexed | 2024-12-16T17:58:36Z |
| format | Article |
| id | doaj.art-c3a1a5d9fcbb48e3b7d8687ce7a75567 |
| institution | Directory Open Access Journal |
| issn | 2363-9024 |
| language | English |
| last_indexed | 2024-12-16T17:58:36Z |
| publishDate | 2019-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | JA Clinical Reports |
| spelling | doaj.art-c3a1a5d9fcbb48e3b7d8687ce7a755672022-12-21T22:22:06ZengSpringerOpenJA Clinical Reports2363-90242019-08-01511410.1186/s40981-019-0275-5Serotonin syndrome triggered by postoperative administration of serotonin noradrenaline reuptake inhibitor (SNRI)Junko Takata0Tomoko Arashi1Ayako Abe2Shoko Arai3Naoko Haruyama4Department of Anesthesiology, Tokyo Metropolitan Police HospitalDepartment of Anesthesiology, Tokyo Metropolitan Police HospitalDepartment of Anesthesiology, Tokyo Metropolitan Police HospitalDepartment of Anesthesiology, Tokyo Metropolitan Police HospitalDepartment of Anesthesiology, Tokyo Metropolitan Police HospitalAbstract Background Serotonin syndrome is a rare but potentially severe disease, which is caused by hyperstimulation of serotonin receptors in the central nervous system. Several antidepressants exert their effect by modulating intrasynaptic serotonin concentration and anesthetics may affect the metabolism of serotonin, implicating to induce serotonin syndrome in patients taking those antidepressants. We present a case which provoked serotonin syndrome immediately after taking serotonin noradrenaline reuptake inhibitor (SNRI) in the postoperative period. Case presentation A 31-year-old female underwent laparoscopic ovarian cystectomy under general anesthesia with propofol, fentanyl, and remifentanil. She has been taking duloxetine, a SNRI for depression. She developed myoclonus seizure with an increase of blood pressure and heart rate after taking duloxetine on the day after the surgery, which was subsided by a non-selective serotonin receptor antagonist. Conclusions Anesthesiologists should be aware of the risk of perioperative serotonin syndrome in patients taking antidepressants affecting serotonin metabolism.http://link.springer.com/article/10.1186/s40981-019-0275-5Serotonin syndromeSNRIFentanylSerotonin |
| spellingShingle | Junko Takata Tomoko Arashi Ayako Abe Shoko Arai Naoko Haruyama Serotonin syndrome triggered by postoperative administration of serotonin noradrenaline reuptake inhibitor (SNRI) JA Clinical Reports Serotonin syndrome SNRI Fentanyl Serotonin |
| title | Serotonin syndrome triggered by postoperative administration of serotonin noradrenaline reuptake inhibitor (SNRI) |
| title_full | Serotonin syndrome triggered by postoperative administration of serotonin noradrenaline reuptake inhibitor (SNRI) |
| title_fullStr | Serotonin syndrome triggered by postoperative administration of serotonin noradrenaline reuptake inhibitor (SNRI) |
| title_full_unstemmed | Serotonin syndrome triggered by postoperative administration of serotonin noradrenaline reuptake inhibitor (SNRI) |
| title_short | Serotonin syndrome triggered by postoperative administration of serotonin noradrenaline reuptake inhibitor (SNRI) |
| title_sort | serotonin syndrome triggered by postoperative administration of serotonin noradrenaline reuptake inhibitor snri |
| topic | Serotonin syndrome SNRI Fentanyl Serotonin |
| url | http://link.springer.com/article/10.1186/s40981-019-0275-5 |
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