Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance
The present study investigated the potential of polydatin to protect against liver injury and the mitochondrial dysfunction of weanling piglets suffering from intra-uterine growth retardation (IUGR). Thirty-six normal birth weight weanling piglets and an equal number of IUGR littermates were given a...
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MDPI AG
2022-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/4/666 |
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| author | Yanan Chen Yue Li Peilu Jia Shuli Ji Hao Zhang Tian Wang |
| author_facet | Yanan Chen Yue Li Peilu Jia Shuli Ji Hao Zhang Tian Wang |
| author_sort | Yanan Chen |
| collection | DOAJ |
| description | The present study investigated the potential of polydatin to protect against liver injury and the mitochondrial dysfunction of weanling piglets suffering from intra-uterine growth retardation (IUGR). Thirty-six normal birth weight weanling piglets and an equal number of IUGR littermates were given a basal diet with or without polydatin (250 mg/kg) from 21 to 35 d of age. Plasma and liver samples were collected to measure biochemistry parameters at 35 d of age. IUGR caused hepatic apoptosis, mitochondrial dysfunction, and oxidative damage, along with a lower efficiency of energy metabolism and inferior antioxidant ability. Polydatin decreased apoptotic rate, improved the features of mitochondrial damage, inhibited mitochondrial swelling and superoxide anion formation, and preserved mitochondrial membrane potential in the liver. Concurrently, polydatin promoted mitochondrial biogenesis, increased sirtuin 1 activity, and upregulated the expression levels of several genes related to mitochondrial function and fitness. Polydatin also facilitated mitochondrial oxidative metabolism with a beneficial outcome of increased energy production. Furthermore, polydatin mitigated the IUGR-induced reduction in manganese superoxide dismutase activity and prevented the excessive accumulation of oxidative damaging products in the liver. These findings indicate that polydatin confers protection against hepatic injury and mitochondrial dysfunction in the IUGR piglets by improving energy metabolism and redox balance. |
| first_indexed | 2024-03-09T11:14:19Z |
| format | Article |
| id | doaj.art-c3a24a46001248a7bc066c53720b3414 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T11:14:19Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-c3a24a46001248a7bc066c53720b34142023-12-01T00:34:40ZengMDPI AGAntioxidants2076-39212022-03-0111466610.3390/antiox11040666Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox BalanceYanan Chen0Yue Li1Peilu Jia2Shuli Ji3Hao Zhang4Tian Wang5College of Animal Science & Technology, Nanjing Agricultural University, Nanjing 210095, ChinaInstitute of Animal Science, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, ChinaCollege of Animal Science & Technology, Nanjing Agricultural University, Nanjing 210095, ChinaCollege of Animal Science & Technology, Nanjing Agricultural University, Nanjing 210095, ChinaCollege of Animal Science & Technology, Nanjing Agricultural University, Nanjing 210095, ChinaCollege of Animal Science & Technology, Nanjing Agricultural University, Nanjing 210095, ChinaThe present study investigated the potential of polydatin to protect against liver injury and the mitochondrial dysfunction of weanling piglets suffering from intra-uterine growth retardation (IUGR). Thirty-six normal birth weight weanling piglets and an equal number of IUGR littermates were given a basal diet with or without polydatin (250 mg/kg) from 21 to 35 d of age. Plasma and liver samples were collected to measure biochemistry parameters at 35 d of age. IUGR caused hepatic apoptosis, mitochondrial dysfunction, and oxidative damage, along with a lower efficiency of energy metabolism and inferior antioxidant ability. Polydatin decreased apoptotic rate, improved the features of mitochondrial damage, inhibited mitochondrial swelling and superoxide anion formation, and preserved mitochondrial membrane potential in the liver. Concurrently, polydatin promoted mitochondrial biogenesis, increased sirtuin 1 activity, and upregulated the expression levels of several genes related to mitochondrial function and fitness. Polydatin also facilitated mitochondrial oxidative metabolism with a beneficial outcome of increased energy production. Furthermore, polydatin mitigated the IUGR-induced reduction in manganese superoxide dismutase activity and prevented the excessive accumulation of oxidative damaging products in the liver. These findings indicate that polydatin confers protection against hepatic injury and mitochondrial dysfunction in the IUGR piglets by improving energy metabolism and redox balance.https://www.mdpi.com/2076-3921/11/4/666energy metabolismintra-uterine growth retardationliver injurymitochondrial dysfunctionweanling pigletpolydatin |
| spellingShingle | Yanan Chen Yue Li Peilu Jia Shuli Ji Hao Zhang Tian Wang Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance Antioxidants energy metabolism intra-uterine growth retardation liver injury mitochondrial dysfunction weanling piglet polydatin |
| title | Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance |
| title_full | Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance |
| title_fullStr | Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance |
| title_full_unstemmed | Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance |
| title_short | Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance |
| title_sort | polydatin attenuates intra uterine growth retardation induced liver injury and mitochondrial dysfunction in weanling piglets by improving energy metabolism and redox balance |
| topic | energy metabolism intra-uterine growth retardation liver injury mitochondrial dysfunction weanling piglet polydatin |
| url | https://www.mdpi.com/2076-3921/11/4/666 |
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