Disorders of carnitine metabolism in premature infants with fan-associated pneumonia
We studied the concentration of carnitine and its fractions in peripheral blood in 22 premature infants with fan-associated pneumonia and in 20 conditionally healthy premature infants by tandem mass spectrometry. The birth body weight of children was 2,086.32 ± 117.13 and 2,140.9 ± 74.4 g, gestation...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2019-09-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/927 |
| _version_ | 1797875197013917696 |
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| author | V. V. Garmaeva G. M. Dementieva M. V. Kushnareva G. V. Baydakova V. S. Sukhorukov E. S. Keshishyan E. Yu. Zakharova |
| author_facet | V. V. Garmaeva G. M. Dementieva M. V. Kushnareva G. V. Baydakova V. S. Sukhorukov E. S. Keshishyan E. Yu. Zakharova |
| author_sort | V. V. Garmaeva |
| collection | DOAJ |
| description | We studied the concentration of carnitine and its fractions in peripheral blood in 22 premature infants with fan-associated pneumonia and in 20 conditionally healthy premature infants by tandem mass spectrometry. The birth body weight of children was 2,086.32 ± 117.13 and 2,140.9 ± 74.4 g, gestational age was 33.7 ± 0.41 and 34.16 ± 0.51 weeks, respectively. The concentration of total carnitine was at the lower limit or decreased in 10 (45%) children in the acute period of the disease. 4 newborns with fan-associated pneumonia demonstrated persistent carnitine deficiency: the content of free carnitine was very low: 7.47 – 8, 37 μmol/l (7.97 ± 0.197 μmol/l), the concentration of total carnitine was also reduced (21.55 – 22.01 μmol/l, 21.7 ± 0.366 μmol/l). The fractions of acylcarnitines varied widely throughout the disease. One child had high rates of C18OH (0.282 μmol/l; norm 0–0.110 μmol/l) and C18:1OH (0.282 μmol/l; norm 0–0.180 μmol/l) during the entire neonatal period. It could be associated with mitochondrial trifunctional protein deficiency. The study of total carnitine and its fractions in premature infants with fan-associated pneumonia allowed us to identify violations of its metabolism, both secondary and hereditary at early stage. |
| first_indexed | 2024-04-10T01:43:47Z |
| format | Article |
| id | doaj.art-c3a3fdd4784b4cd3bb8c2dd5bf0f33c0 |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:43:47Z |
| publishDate | 2019-09-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-c3a3fdd4784b4cd3bb8c2dd5bf0f33c02023-03-13T09:12:47ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282019-09-01644455110.21508/1027-4065-2019-64-4-45-51757Disorders of carnitine metabolism in premature infants with fan-associated pneumoniaV. V. Garmaeva0G. M. Dementieva1M. V. Kushnareva2G. V. Baydakova3V. S. Sukhorukov4E. S. Keshishyan5E. Yu. Zakharova6Детская клиника МЕДСИОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РФОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РФФГБНУ «Медико-генетический научный центр» Министерства науки и высшего образования РоссииФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РФФГБНУ «Медико-генетический научный центр» Министерства науки и высшего образования РоссииWe studied the concentration of carnitine and its fractions in peripheral blood in 22 premature infants with fan-associated pneumonia and in 20 conditionally healthy premature infants by tandem mass spectrometry. The birth body weight of children was 2,086.32 ± 117.13 and 2,140.9 ± 74.4 g, gestational age was 33.7 ± 0.41 and 34.16 ± 0.51 weeks, respectively. The concentration of total carnitine was at the lower limit or decreased in 10 (45%) children in the acute period of the disease. 4 newborns with fan-associated pneumonia demonstrated persistent carnitine deficiency: the content of free carnitine was very low: 7.47 – 8, 37 μmol/l (7.97 ± 0.197 μmol/l), the concentration of total carnitine was also reduced (21.55 – 22.01 μmol/l, 21.7 ± 0.366 μmol/l). The fractions of acylcarnitines varied widely throughout the disease. One child had high rates of C18OH (0.282 μmol/l; norm 0–0.110 μmol/l) and C18:1OH (0.282 μmol/l; norm 0–0.180 μmol/l) during the entire neonatal period. It could be associated with mitochondrial trifunctional protein deficiency. The study of total carnitine and its fractions in premature infants with fan-associated pneumonia allowed us to identify violations of its metabolism, both secondary and hereditary at early stage.https://www.ped-perinatology.ru/jour/article/view/927недоношенные новорожденные дети«вентилятор-ассоциированная» пневмониякарнитинметаболизмкровь |
| spellingShingle | V. V. Garmaeva G. M. Dementieva M. V. Kushnareva G. V. Baydakova V. S. Sukhorukov E. S. Keshishyan E. Yu. Zakharova Disorders of carnitine metabolism in premature infants with fan-associated pneumonia Rossijskij Vestnik Perinatologii i Pediatrii недоношенные новорожденные дети «вентилятор-ассоциированная» пневмония карнитин метаболизм кровь |
| title | Disorders of carnitine metabolism in premature infants with fan-associated pneumonia |
| title_full | Disorders of carnitine metabolism in premature infants with fan-associated pneumonia |
| title_fullStr | Disorders of carnitine metabolism in premature infants with fan-associated pneumonia |
| title_full_unstemmed | Disorders of carnitine metabolism in premature infants with fan-associated pneumonia |
| title_short | Disorders of carnitine metabolism in premature infants with fan-associated pneumonia |
| title_sort | disorders of carnitine metabolism in premature infants with fan associated pneumonia |
| topic | недоношенные новорожденные дети «вентилятор-ассоциированная» пневмония карнитин метаболизм кровь |
| url | https://www.ped-perinatology.ru/jour/article/view/927 |
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