Investigating the Role of Insight, Decision-Making and Mentalizing in Functional Outcome in Schizophrenia: A Cross-Sectional Study
Background: Recovery has become a priority in schizophrenia spectrum disorders (SSDs). This study aimed to investigate predictors of objective—general functioning and disability—and subjective—quality of life (QoL)—measures of functional outcomes in SSD. Methods: Sample: <i>n</i> = 77 SS...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Behavioral Sciences |
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| Online Access: | https://www.mdpi.com/2076-328X/12/2/28 |
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| author | Paula Jhoana Escobedo-Aedo Ana Forjan-González Adela Sánchez-Escribano Martínez Verónica González Ruiz-Ruano Sergio Sánchez-Alonso Laura Mata-Iturralde Laura Muñoz-Lorenzo Enrique Baca-García Anthony S. David Javier-David Lopez-Morinigo |
| author_facet | Paula Jhoana Escobedo-Aedo Ana Forjan-González Adela Sánchez-Escribano Martínez Verónica González Ruiz-Ruano Sergio Sánchez-Alonso Laura Mata-Iturralde Laura Muñoz-Lorenzo Enrique Baca-García Anthony S. David Javier-David Lopez-Morinigo |
| author_sort | Paula Jhoana Escobedo-Aedo |
| collection | DOAJ |
| description | Background: Recovery has become a priority in schizophrenia spectrum disorders (SSDs). This study aimed to investigate predictors of objective—general functioning and disability—and subjective—quality of life (QoL)—measures of functional outcomes in SSD. Methods: Sample: <i>n</i> = 77 SSD outpatients (age 18–64, IQ > 70) participating in a randomised controlled trial. Baseline data were used to build three multivariable linear regression models on: (i) general functioning—General Assessment of Functioning (GAF); (ii) disability—the World Health Organization Disability Assessment Schedule (WHODAS-2.0); and (iii) QoL—Satisfaction Life Domains Scale (SLDS). Results: Young age and being employed (R<sup>2</sup> change = 0.211; <i>p</i> = 0.001), late adolescence premorbid adjustment (R<sup>2</sup> change = 0.049; <i>p</i> = 0.0050), negative symptoms and disorganization (R<sup>2</sup> change = 0.087; <i>p</i> = 0.025) and Theory of Mind (R<sup>2</sup> change = 0.066, <i>p</i> = 0.053) predicted general functioning. Previous suicidal behaviour (R<sup>2</sup> change = 0.068; <i>p</i> = 0.023) and negative and depressive symptoms (R<sup>2</sup> change = 0.167; <i>p</i> = 0.001) were linked with disability. Previous suicidal behaviour (R<sup>2</sup> change = 0.070, <i>p</i> = 0.026), depressive symptoms (R<sup>2</sup> change = 0.157; <i>p</i> < 0.001) and illness recognition (R<sup>2</sup> change = 0.046, <i>p</i> = 0.044) predicted QoL. Conclusions: Negative, disorganization and depressive symptoms, older age, unemployment, poor premorbid adjustment, previous suicide attempts and illness awareness appear to underlie a poor global functional outcome in SSD. Achieving recovery in SSD appears to require both symptomatic remission (e.g., through antipsychotics) and measures to improve mastery and relieve low mood. |
| first_indexed | 2024-03-09T22:37:01Z |
| format | Article |
| id | doaj.art-c3a5e71bdaab49c9a0d164ea1d36b25c |
| institution | Directory Open Access Journal |
| issn | 2076-328X |
| language | English |
| last_indexed | 2024-03-09T22:37:01Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Behavioral Sciences |
| spelling | doaj.art-c3a5e71bdaab49c9a0d164ea1d36b25c2023-11-23T18:47:46ZengMDPI AGBehavioral Sciences2076-328X2022-01-011222810.3390/bs12020028Investigating the Role of Insight, Decision-Making and Mentalizing in Functional Outcome in Schizophrenia: A Cross-Sectional StudyPaula Jhoana Escobedo-Aedo0Ana Forjan-González1Adela Sánchez-Escribano Martínez2Verónica González Ruiz-Ruano3Sergio Sánchez-Alonso4Laura Mata-Iturralde5Laura Muñoz-Lorenzo6Enrique Baca-García7Anthony S. David8Javier-David Lopez-Morinigo9Departamento de Psiquiatría, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainDepartamento de Psiquiatría, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainDepartamento de Psiquiatría, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainDepartamento de Psiquiatría, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainDepartamento de Psiquiatría, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainDepartamento de Psiquiatría, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainDepartamento de Psiquiatría, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainDepartamento de Psiquiatría, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainDivision of Psychiatry, Faculty of Brain Sciences, Institute of Mental Health, University College London, London WC1E 6BT, UKDepartamento de Psiquiatría, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainBackground: Recovery has become a priority in schizophrenia spectrum disorders (SSDs). This study aimed to investigate predictors of objective—general functioning and disability—and subjective—quality of life (QoL)—measures of functional outcomes in SSD. Methods: Sample: <i>n</i> = 77 SSD outpatients (age 18–64, IQ > 70) participating in a randomised controlled trial. Baseline data were used to build three multivariable linear regression models on: (i) general functioning—General Assessment of Functioning (GAF); (ii) disability—the World Health Organization Disability Assessment Schedule (WHODAS-2.0); and (iii) QoL—Satisfaction Life Domains Scale (SLDS). Results: Young age and being employed (R<sup>2</sup> change = 0.211; <i>p</i> = 0.001), late adolescence premorbid adjustment (R<sup>2</sup> change = 0.049; <i>p</i> = 0.0050), negative symptoms and disorganization (R<sup>2</sup> change = 0.087; <i>p</i> = 0.025) and Theory of Mind (R<sup>2</sup> change = 0.066, <i>p</i> = 0.053) predicted general functioning. Previous suicidal behaviour (R<sup>2</sup> change = 0.068; <i>p</i> = 0.023) and negative and depressive symptoms (R<sup>2</sup> change = 0.167; <i>p</i> = 0.001) were linked with disability. Previous suicidal behaviour (R<sup>2</sup> change = 0.070, <i>p</i> = 0.026), depressive symptoms (R<sup>2</sup> change = 0.157; <i>p</i> < 0.001) and illness recognition (R<sup>2</sup> change = 0.046, <i>p</i> = 0.044) predicted QoL. Conclusions: Negative, disorganization and depressive symptoms, older age, unemployment, poor premorbid adjustment, previous suicide attempts and illness awareness appear to underlie a poor global functional outcome in SSD. Achieving recovery in SSD appears to require both symptomatic remission (e.g., through antipsychotics) and measures to improve mastery and relieve low mood.https://www.mdpi.com/2076-328X/12/2/28metacognitionschizophrenia spectrum disordersdisabilityfunctioningquality of life |
| spellingShingle | Paula Jhoana Escobedo-Aedo Ana Forjan-González Adela Sánchez-Escribano Martínez Verónica González Ruiz-Ruano Sergio Sánchez-Alonso Laura Mata-Iturralde Laura Muñoz-Lorenzo Enrique Baca-García Anthony S. David Javier-David Lopez-Morinigo Investigating the Role of Insight, Decision-Making and Mentalizing in Functional Outcome in Schizophrenia: A Cross-Sectional Study Behavioral Sciences metacognition schizophrenia spectrum disorders disability functioning quality of life |
| title | Investigating the Role of Insight, Decision-Making and Mentalizing in Functional Outcome in Schizophrenia: A Cross-Sectional Study |
| title_full | Investigating the Role of Insight, Decision-Making and Mentalizing in Functional Outcome in Schizophrenia: A Cross-Sectional Study |
| title_fullStr | Investigating the Role of Insight, Decision-Making and Mentalizing in Functional Outcome in Schizophrenia: A Cross-Sectional Study |
| title_full_unstemmed | Investigating the Role of Insight, Decision-Making and Mentalizing in Functional Outcome in Schizophrenia: A Cross-Sectional Study |
| title_short | Investigating the Role of Insight, Decision-Making and Mentalizing in Functional Outcome in Schizophrenia: A Cross-Sectional Study |
| title_sort | investigating the role of insight decision making and mentalizing in functional outcome in schizophrenia a cross sectional study |
| topic | metacognition schizophrenia spectrum disorders disability functioning quality of life |
| url | https://www.mdpi.com/2076-328X/12/2/28 |
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