Duration effects of alcohol graded concentrations on the extent of lipid peroxidation, testis morphology and sperm quality assessment in Wistar rats
Alcohol consumption is known to cause an array of alcohol-induced biochemical changes in a biological system. This study investigated the durations effects of different alcohol concentrations (30%, 40%, and 50%) on malondialdehyde levels, testes histology, and sperm characteristics in matured male W...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750022001172 |
| _version_ | 1811188532871430144 |
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| author | Dorcas Ibukun Akinloye Regina Ngozi Ugbaja Adekunle Adeniyi Adebiyi Olusegun Mark Obafemi Idowu |
| author_facet | Dorcas Ibukun Akinloye Regina Ngozi Ugbaja Adekunle Adeniyi Adebiyi Olusegun Mark Obafemi Idowu |
| author_sort | Dorcas Ibukun Akinloye |
| collection | DOAJ |
| description | Alcohol consumption is known to cause an array of alcohol-induced biochemical changes in a biological system. This study investigated the durations effects of different alcohol concentrations (30%, 40%, and 50%) on malondialdehyde levels, testes histology, and sperm characteristics in matured male Wistar rats. The rats were divided into four groups namely thus; control, 30%, 40% and 50%. Control group was orally administered 0% alcohol while, group 30%, 40% and 50% received orally 30%, 40% and 50% of alcohol concentrations (3.20 g/ Kg body weight) respectively for maximum durations of 28 days. On the day 1, 7, 14, 21, and 28, five rats from each group (control, 30%, 40% and 50% alcohol) were sacrificed, and malondialdehyde levels, testes histology, and sperm characteristics were examined.Graded alcohol concentrations caused different detrimental effects on sperm characteristics and induced pathological lesions in the testes. Significant increases in serum, liver and testes malondialdehyde levels were durations independent but almost entirely concentrations dependent.Ultimately, administration of alcohol graded concentration led to loss of sperm motility and testicular degeneration in concentration and durations dependent manner without a concomitant increase in the malondialdehyde levels. |
| first_indexed | 2024-04-11T14:21:34Z |
| format | Article |
| id | doaj.art-c3a5ee0551204285b4b9b7b8862813cb |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-04-11T14:21:34Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-c3a5ee0551204285b4b9b7b8862813cb2022-12-22T04:19:03ZengElsevierToxicology Reports2214-75002022-01-01910821091Duration effects of alcohol graded concentrations on the extent of lipid peroxidation, testis morphology and sperm quality assessment in Wistar ratsDorcas Ibukun Akinloye0Regina Ngozi Ugbaja1Adekunle Adeniyi Adebiyi2Olusegun Mark Obafemi Idowu3Department of Biochemistry, College of Biosciences, Federal University of Agriculture, P.M.B. 2240, Abeokuta, Nigeria; Corresponding author.Department of Biochemistry, College of Biosciences, Federal University of Agriculture, P.M.B. 2240, Abeokuta, NigeriaDepartment of Veterinary Pathology, College of Veterinary Medicine, Federal University of Agriculture, P.M.B. 2240, Abeokuta, NigeriaDepartment of Animal Nutrition, College of Animal Sciences and Livestock Production, Federal University of Agriculture, P.M.B. 2240, Abeokuta, NigeriaAlcohol consumption is known to cause an array of alcohol-induced biochemical changes in a biological system. This study investigated the durations effects of different alcohol concentrations (30%, 40%, and 50%) on malondialdehyde levels, testes histology, and sperm characteristics in matured male Wistar rats. The rats were divided into four groups namely thus; control, 30%, 40% and 50%. Control group was orally administered 0% alcohol while, group 30%, 40% and 50% received orally 30%, 40% and 50% of alcohol concentrations (3.20 g/ Kg body weight) respectively for maximum durations of 28 days. On the day 1, 7, 14, 21, and 28, five rats from each group (control, 30%, 40% and 50% alcohol) were sacrificed, and malondialdehyde levels, testes histology, and sperm characteristics were examined.Graded alcohol concentrations caused different detrimental effects on sperm characteristics and induced pathological lesions in the testes. Significant increases in serum, liver and testes malondialdehyde levels were durations independent but almost entirely concentrations dependent.Ultimately, administration of alcohol graded concentration led to loss of sperm motility and testicular degeneration in concentration and durations dependent manner without a concomitant increase in the malondialdehyde levels.http://www.sciencedirect.com/science/article/pii/S2214750022001172DurationsAlcohol concentrationsSperm motilityMDA levelsTesticular degeneration |
| spellingShingle | Dorcas Ibukun Akinloye Regina Ngozi Ugbaja Adekunle Adeniyi Adebiyi Olusegun Mark Obafemi Idowu Duration effects of alcohol graded concentrations on the extent of lipid peroxidation, testis morphology and sperm quality assessment in Wistar rats Toxicology Reports Durations Alcohol concentrations Sperm motility MDA levels Testicular degeneration |
| title | Duration effects of alcohol graded concentrations on the extent of lipid peroxidation, testis morphology and sperm quality assessment in Wistar rats |
| title_full | Duration effects of alcohol graded concentrations on the extent of lipid peroxidation, testis morphology and sperm quality assessment in Wistar rats |
| title_fullStr | Duration effects of alcohol graded concentrations on the extent of lipid peroxidation, testis morphology and sperm quality assessment in Wistar rats |
| title_full_unstemmed | Duration effects of alcohol graded concentrations on the extent of lipid peroxidation, testis morphology and sperm quality assessment in Wistar rats |
| title_short | Duration effects of alcohol graded concentrations on the extent of lipid peroxidation, testis morphology and sperm quality assessment in Wistar rats |
| title_sort | duration effects of alcohol graded concentrations on the extent of lipid peroxidation testis morphology and sperm quality assessment in wistar rats |
| topic | Durations Alcohol concentrations Sperm motility MDA levels Testicular degeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2214750022001172 |
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