Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis
Uncaria tomentosa is a plant that has been used in traditional medicine for its anti-inflammatory, immunomodulatory, and immunostimulant properties. As a result, it can be found in several over-the-counter supplements worldwide. Acute interstitial nephritis (AIN) can be due to an offending medicatio...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2022-10-01
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| Series: | Case Reports in Nephrology and Dialysis |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/526391 |
| _version_ | 1811179923302252544 |
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| author | Gilda Portalatin Shruti Shettigar Astrid Carrion-Rodriguez Sushma Medikayala Leal Herlitz Dianne Sandy Surafel K. Gebreselassie Shane A. Bobart |
| author_facet | Gilda Portalatin Shruti Shettigar Astrid Carrion-Rodriguez Sushma Medikayala Leal Herlitz Dianne Sandy Surafel K. Gebreselassie Shane A. Bobart |
| author_sort | Gilda Portalatin |
| collection | DOAJ |
| description | Uncaria tomentosa is a plant that has been used in traditional medicine for its anti-inflammatory, immunomodulatory, and immunostimulant properties. As a result, it can be found in several over-the-counter supplements worldwide. Acute interstitial nephritis (AIN) can be due to an offending medication, infection, or autoimmunity. We present a case of a patient who was on a strict ketogenic diet, utilizing over-the-counter diet shakes containing the herbal supplement Uncaria tomentosa who developed acute kidney injury with a serum creatinine of 3.6 mg/dL up from a baseline of 0.7 mg/dL. Serological evaluation was negative, and kidney biopsy revealed interstitial inflammatory infiltrates including focally prominent eosinophils and multifocal tubulitis. Stopping the keto-diet shake containing Uncaria tomentosa and concomitant corticosteroid therapy resulted in improvement in kidney function to near baseline. To our knowledge, this is the only biopsy-proven case of AIN in the setting of Uncaria tomentosa use. |
| first_indexed | 2024-04-11T06:42:50Z |
| format | Article |
| id | doaj.art-c3a816ee1e2243119320b51a9a8c8d8b |
| institution | Directory Open Access Journal |
| issn | 2296-9705 |
| language | English |
| last_indexed | 2024-04-11T06:42:50Z |
| publishDate | 2022-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Nephrology and Dialysis |
| spelling | doaj.art-c3a816ee1e2243119320b51a9a8c8d8b2022-12-22T04:39:29ZengKarger PublishersCase Reports in Nephrology and Dialysis2296-97052022-10-0112321922510.1159/000526391526391Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial NephritisGilda Portalatin0Shruti Shettigar1Astrid Carrion-Rodriguez2Sushma Medikayala3Leal Herlitz4https://orcid.org/0000-0003-2665-8559Dianne Sandy5Surafel K. Gebreselassie6Shane A. Bobart7Department of Internal Medicine, Cleveland Clinic Florida, Weston, FL, USADepartment of Internal Medicine, Cleveland Clinic Florida, Weston, FL, USADepartment of Internal Medicine, Cleveland Clinic Florida, Weston, FL, USADepartment of Kidney Medicine, Cleveland Clinic Florida, Weston, FL, USADepartment of Pathology, Cleveland Clinic Ohio, Cleveland, OH, USADepartment of Kidney Medicine, Cleveland Clinic Florida, Weston, FL, USADepartment of Kidney Medicine, Cleveland Clinic Florida, Weston, FL, USADepartment of Kidney Medicine, Cleveland Clinic Florida, Weston, FL, USAUncaria tomentosa is a plant that has been used in traditional medicine for its anti-inflammatory, immunomodulatory, and immunostimulant properties. As a result, it can be found in several over-the-counter supplements worldwide. Acute interstitial nephritis (AIN) can be due to an offending medication, infection, or autoimmunity. We present a case of a patient who was on a strict ketogenic diet, utilizing over-the-counter diet shakes containing the herbal supplement Uncaria tomentosa who developed acute kidney injury with a serum creatinine of 3.6 mg/dL up from a baseline of 0.7 mg/dL. Serological evaluation was negative, and kidney biopsy revealed interstitial inflammatory infiltrates including focally prominent eosinophils and multifocal tubulitis. Stopping the keto-diet shake containing Uncaria tomentosa and concomitant corticosteroid therapy resulted in improvement in kidney function to near baseline. To our knowledge, this is the only biopsy-proven case of AIN in the setting of Uncaria tomentosa use.https://www.karger.com/Article/FullText/526391keto-dietacute interstitial nephritisketo shakekidney biopsy |
| spellingShingle | Gilda Portalatin Shruti Shettigar Astrid Carrion-Rodriguez Sushma Medikayala Leal Herlitz Dianne Sandy Surafel K. Gebreselassie Shane A. Bobart Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis Case Reports in Nephrology and Dialysis keto-diet acute interstitial nephritis keto shake kidney biopsy |
| title | Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis |
| title_full | Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis |
| title_fullStr | Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis |
| title_full_unstemmed | Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis |
| title_short | Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis |
| title_sort | ketogenic diet shake containing uncaria tomentosa associated acute interstitial nephritis |
| topic | keto-diet acute interstitial nephritis keto shake kidney biopsy |
| url | https://www.karger.com/Article/FullText/526391 |
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