Synthesis and cellular evaluation of click-chemistry probes to study the biological effects of alpha, beta-unsaturated carbonyls

Synthesis and cellular evaluation of click-chemistry probes to study the biological effects of alpha, beta-unsaturated carbonyls

Humans are commonly exposed to α,β-unsaturated carbonyls as both environmental toxins (e.g. acrolein) and therapeutic drugs (e.g. dimethylfumarate, DMFU, a front-line drug for the treatment of multiple sclerosis and psoriasis). These compounds undergo rapid Michael addition reactions with amine, imi...

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Bibliographic Details
Main Authors:	Chiara Morozzi, Max Sauerland, Luke F. Gamon, Asmita Manandhar, Trond Ulven, Michael J. Davies
Format:	Article
Language:	English
Published:	Elsevier 2022-06-01
Series:	Redox Biology
Subjects:	Dimethylfumarate Unsaturated carbonyls Michael adduct Click chemistry GAPDH Electrophile
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231722000714

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