Allosteric cooperation in β-lactam binding to a non-classical transpeptidase

Allosteric cooperation in β-lactam binding to a non-classical transpeptidase

L,D-transpeptidase function predominates in atypical 3 → 3 transpeptide networking of peptidoglycan (PG) layer in Mycobacterium tuberculosis. Prior studies of L,D-transpeptidases have identified only the catalytic site that binds to peptide moiety of the PG substrate or β-lactam antibiotics. This in...

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Bibliographic Details
Main Authors: Nazia Ahmad, Sanmati Dugad, Varsha Chauhan, Shubbir Ahmed, Kunal Sharma, Sangita Kachhap, Rana Zaidi, William R Bishai, Gyanu Lamichhane, Pankaj Kumar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
Mycobacterium tuberculosis
β-lactam
peptidoglycan
L,D-transpeptidase
allostery
Online Access:https://elifesciences.org/articles/73055

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