Pachybasin, a Major Metabolite from Culture Broth of Endophytic Coelomyceteous AFKR-18 Fungus isolated from a Yellow Moonsheed Plant, Arcangelisia flava (L.) Merr.
Endophytic fungi have been known to produce a broad range of biologically active secondary metabolites. One endophytic filamentous fungus, Coelomycetes AFKR-18, isolated from the young stems of a yellow moonsheed plant, Arcangelisia flava, has been found to produce pachybasin when placed in a liquid...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bogor Agricultural University
2014-06-01
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| Series: | Hayati Journal of Biosciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1978301916300596 |
| Summary: | Endophytic fungi have been known to produce a broad range of biologically active secondary metabolites. One endophytic filamentous fungus, Coelomycetes AFKR-18, isolated from the young stems of a yellow moonsheed plant, Arcangelisia flava, has been found to produce pachybasin when placed in a liquid medium. The chemical structure of pachybasin was deduced from MS, 1D-, 2D-NMR spectrum analysis, and from reference data. On a micro-dilution test, pachybasin showed antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively. |
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| ISSN: | 1978-3019 |