Acetylsalicylic Acid and Mood Disorders: A Systematic Review
The effects of acetylsalicylic acid (ASA) on mood disorders (MD) and on inflammatory parameters in preclinical and clinical studies have not yet been comprehensively evaluated. The aim of this study was to systematically summarize the available knowledge on this topic according to PRISMA guidelines....
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/1/67 |
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| author | Monika Dominiak Adam Gędek Michalina Sikorska Paweł Mierzejewski Marcin Wojnar Anna Z. Antosik-Wójcińska |
| author_facet | Monika Dominiak Adam Gędek Michalina Sikorska Paweł Mierzejewski Marcin Wojnar Anna Z. Antosik-Wójcińska |
| author_sort | Monika Dominiak |
| collection | DOAJ |
| description | The effects of acetylsalicylic acid (ASA) on mood disorders (MD) and on inflammatory parameters in preclinical and clinical studies have not yet been comprehensively evaluated. The aim of this study was to systematically summarize the available knowledge on this topic according to PRISMA guidelines. Data from preclinical and clinical studies were analyzed, considering the safety and efficacy of ASA in the treatment of MD and the correlation of inflammatory parameters with the effect of ASA treatment. Twenty-one studies were included. Both preclinical and clinical studies found evidence indicating the safety and efficacy of low-dose ASA in the treatment of all types of affective episodes in MD. Observational studies have indicated a reduced risk of all types of affective episodes in chronic low-dose ASA users (HR 0.92, 95% CI: 0.88, 0.95, <i>p</i> < 0.0001). An association between ASA response and inflammatory parameters was found in preclinical studies, but this was not confirmed in clinical trials. Further long-term clinical trials evaluating the safety and efficacy of ASA in recurrent MD, as well as assessing the linkage of ASA treatment with inflammatory phenotype and cytokines, are required. There is also a need for preclinical studies to understand the exact mechanism of action of ASA in MD. |
| first_indexed | 2024-03-09T11:29:50Z |
| format | Article |
| id | doaj.art-c3ada70429c34dcaad61c37031d69eca |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T11:29:50Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-c3ada70429c34dcaad61c37031d69eca2023-11-30T23:55:19ZengMDPI AGPharmaceuticals1424-82472022-12-011616710.3390/ph16010067Acetylsalicylic Acid and Mood Disorders: A Systematic ReviewMonika Dominiak0Adam Gędek1Michalina Sikorska2Paweł Mierzejewski3Marcin Wojnar4Anna Z. Antosik-Wójcińska5Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957 Warsaw, PolandPraski Hospital, Aleja Solidarności 67, 03-401 Warsaw, PolandMedical Center of Postgraduate Education, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, PolandDepartment of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957 Warsaw, PolandDepartment of Psychiatry, Medical University of Warsaw, Nowowiejska 27, 00-665 Warsaw, PolandDepartment of Psychiatry Faculty of Medicine, Collegium Medicum, Cardinal Wyszynski University in Warsaw, Woycickiego 1/3, 01-938 Warsaw, PolandThe effects of acetylsalicylic acid (ASA) on mood disorders (MD) and on inflammatory parameters in preclinical and clinical studies have not yet been comprehensively evaluated. The aim of this study was to systematically summarize the available knowledge on this topic according to PRISMA guidelines. Data from preclinical and clinical studies were analyzed, considering the safety and efficacy of ASA in the treatment of MD and the correlation of inflammatory parameters with the effect of ASA treatment. Twenty-one studies were included. Both preclinical and clinical studies found evidence indicating the safety and efficacy of low-dose ASA in the treatment of all types of affective episodes in MD. Observational studies have indicated a reduced risk of all types of affective episodes in chronic low-dose ASA users (HR 0.92, 95% CI: 0.88, 0.95, <i>p</i> < 0.0001). An association between ASA response and inflammatory parameters was found in preclinical studies, but this was not confirmed in clinical trials. Further long-term clinical trials evaluating the safety and efficacy of ASA in recurrent MD, as well as assessing the linkage of ASA treatment with inflammatory phenotype and cytokines, are required. There is also a need for preclinical studies to understand the exact mechanism of action of ASA in MD.https://www.mdpi.com/1424-8247/16/1/67acetylsalicylic acidaspirinASAmood disordersbipolar disordermajor depression |
| spellingShingle | Monika Dominiak Adam Gędek Michalina Sikorska Paweł Mierzejewski Marcin Wojnar Anna Z. Antosik-Wójcińska Acetylsalicylic Acid and Mood Disorders: A Systematic Review Pharmaceuticals acetylsalicylic acid aspirin ASA mood disorders bipolar disorder major depression |
| title | Acetylsalicylic Acid and Mood Disorders: A Systematic Review |
| title_full | Acetylsalicylic Acid and Mood Disorders: A Systematic Review |
| title_fullStr | Acetylsalicylic Acid and Mood Disorders: A Systematic Review |
| title_full_unstemmed | Acetylsalicylic Acid and Mood Disorders: A Systematic Review |
| title_short | Acetylsalicylic Acid and Mood Disorders: A Systematic Review |
| title_sort | acetylsalicylic acid and mood disorders a systematic review |
| topic | acetylsalicylic acid aspirin ASA mood disorders bipolar disorder major depression |
| url | https://www.mdpi.com/1424-8247/16/1/67 |
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