Effects of Glucose Metabolism, Lipid Metabolism, and Glutamine Metabolism on Tumor Microenvironment and Clinical Implications
In recent years, an increasingly more in depth understanding of tumor metabolism in tumorigenesis, tumor growth, metastasis, and prognosis has been achieved. The broad heterogeneity in tumor tissue is the critical factor affecting the outcome of tumor treatment. Metabolic heterogeneity is not only f...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/4/580 |
| _version_ | 1797436710541328384 |
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| author | Longfei Zhu Xuanyu Zhu Yan Wu |
| author_facet | Longfei Zhu Xuanyu Zhu Yan Wu |
| author_sort | Longfei Zhu |
| collection | DOAJ |
| description | In recent years, an increasingly more in depth understanding of tumor metabolism in tumorigenesis, tumor growth, metastasis, and prognosis has been achieved. The broad heterogeneity in tumor tissue is the critical factor affecting the outcome of tumor treatment. Metabolic heterogeneity is not only found in tumor cells but also in their surrounding immune and stromal cells; for example, many suppressor cells, such as tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and tumor-associated T-lymphocytes. Abnormalities in metabolism often lead to short survival or resistance to antitumor therapy, e.g., chemotherapy, radiotherapy, targeted therapy, and immunotherapy. Using the metabolic characteristics of the tumor microenvironment to identify and treat cancer has become a great research hotspot. This review systematically addresses the impacts of metabolism on tumor cells and effector cells and represents recent research advances of metabolic effects on other cells in the tumor microenvironment. Finally, we introduce some applications of metabolic features in clinical oncology. |
| first_indexed | 2024-03-09T11:06:29Z |
| format | Article |
| id | doaj.art-c3ae87b63ce74f93b1ccf124c755ddcc |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T11:06:29Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-c3ae87b63ce74f93b1ccf124c755ddcc2023-12-01T00:57:12ZengMDPI AGBiomolecules2218-273X2022-04-0112458010.3390/biom12040580Effects of Glucose Metabolism, Lipid Metabolism, and Glutamine Metabolism on Tumor Microenvironment and Clinical ImplicationsLongfei Zhu0Xuanyu Zhu1Yan Wu2The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang 212001, ChinaThe Fourth Affiliated Hospital of Jiangsu University, Zhenjiang 212001, ChinaThe Fourth Affiliated Hospital of Jiangsu University, Zhenjiang 212001, ChinaIn recent years, an increasingly more in depth understanding of tumor metabolism in tumorigenesis, tumor growth, metastasis, and prognosis has been achieved. The broad heterogeneity in tumor tissue is the critical factor affecting the outcome of tumor treatment. Metabolic heterogeneity is not only found in tumor cells but also in their surrounding immune and stromal cells; for example, many suppressor cells, such as tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and tumor-associated T-lymphocytes. Abnormalities in metabolism often lead to short survival or resistance to antitumor therapy, e.g., chemotherapy, radiotherapy, targeted therapy, and immunotherapy. Using the metabolic characteristics of the tumor microenvironment to identify and treat cancer has become a great research hotspot. This review systematically addresses the impacts of metabolism on tumor cells and effector cells and represents recent research advances of metabolic effects on other cells in the tumor microenvironment. Finally, we introduce some applications of metabolic features in clinical oncology.https://www.mdpi.com/2218-273X/12/4/580metabolismtumor microenvironmentimmunotherapyglycolysisfatty acid metabolismglutaminolysis |
| spellingShingle | Longfei Zhu Xuanyu Zhu Yan Wu Effects of Glucose Metabolism, Lipid Metabolism, and Glutamine Metabolism on Tumor Microenvironment and Clinical Implications Biomolecules metabolism tumor microenvironment immunotherapy glycolysis fatty acid metabolism glutaminolysis |
| title | Effects of Glucose Metabolism, Lipid Metabolism, and Glutamine Metabolism on Tumor Microenvironment and Clinical Implications |
| title_full | Effects of Glucose Metabolism, Lipid Metabolism, and Glutamine Metabolism on Tumor Microenvironment and Clinical Implications |
| title_fullStr | Effects of Glucose Metabolism, Lipid Metabolism, and Glutamine Metabolism on Tumor Microenvironment and Clinical Implications |
| title_full_unstemmed | Effects of Glucose Metabolism, Lipid Metabolism, and Glutamine Metabolism on Tumor Microenvironment and Clinical Implications |
| title_short | Effects of Glucose Metabolism, Lipid Metabolism, and Glutamine Metabolism on Tumor Microenvironment and Clinical Implications |
| title_sort | effects of glucose metabolism lipid metabolism and glutamine metabolism on tumor microenvironment and clinical implications |
| topic | metabolism tumor microenvironment immunotherapy glycolysis fatty acid metabolism glutaminolysis |
| url | https://www.mdpi.com/2218-273X/12/4/580 |
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