Strategies to induce natural killer cell tolerance in xenotransplantation

Strategies to induce natural killer cell tolerance in xenotransplantation

Eliminating major xenoantigens in pig cells has drastically reduced human antibody-mediated hyperacute xenograft rejection (HXR). Despite these advancements, acute xenograft rejection (AXR) remains one of the major obstacles to clinical xenotransplantation, mediated by innate immune cells, including...

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Bibliographic Details
Main Authors: Kevin J. Lopez, Arthur A. Cross-Najafi, Kristine Farag, Benjamin Obando, Deepthi Thadasina, Abdulkadir Isidan, Yujin Park, Wenjun Zhang, Burcin Ekser, Ping Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
NK cells
NK cell tolerance
xenotransplant
xenotranplantation
tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.941880/full

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