The relevance between hypoxia-dependent spatial transcriptomics and the prognosis and efficacy of immunotherapy in claudin-low breast cancer

The relevance between hypoxia-dependent spatial transcriptomics and the prognosis and efficacy of immunotherapy in claudin-low breast cancer

IntroductionHypoxia is an important characteristic of solid tumors. However, spatial transcriptomics (ST) of hypoxia-associated heterogeneity is not clear.MethodsThis study integrated Spatial Transcriptomics (ST) with immunofluorescence to demonstrate their spatial distribution in human claudin-low...

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Bibliographic Details
Main Authors: Huizhi Sun, Yanlei Li, Yanhui Zhang, Xiulan Zhao, Xueyi Dong, Yuhong Guo, Jing Mo, Na Che, Xinchao Ban, Fan Li, Xiaoyu Bai, Yue Li, Jihui Hao, Danfang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
breast cancer
hypoxia
spatial transcriptomics
Claudin-low tumor
immune cell infiltration
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1042835/full

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