Dipterocarpus tuberculatus as a promising anti-obesity treatment in Lep knockout mice
IntroductionThe therapeutic effects and mechanisms of Dipterocarpus tuberculatus (D. tuberculatus) extracts have been examined concerning inflammation, photoaging, and gastritis; however, their effect on obesity is still being investigated.MethodsWe administered a methanol extract of D. tuberculatus...
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1167285/full |
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| author | Yu Jeong Roh Su Jin Lee Ji Eun Kim You Jeong Jin Ayun Seol Hee Jin Song Jumin Park So Hae Park Bounleuane Douangdeuane Onevilay Souliya Sun Il Choi Dae Youn Hwang Dae Youn Hwang |
| author_facet | Yu Jeong Roh Su Jin Lee Ji Eun Kim You Jeong Jin Ayun Seol Hee Jin Song Jumin Park So Hae Park Bounleuane Douangdeuane Onevilay Souliya Sun Il Choi Dae Youn Hwang Dae Youn Hwang |
| author_sort | Yu Jeong Roh |
| collection | DOAJ |
| description | IntroductionThe therapeutic effects and mechanisms of Dipterocarpus tuberculatus (D. tuberculatus) extracts have been examined concerning inflammation, photoaging, and gastritis; however, their effect on obesity is still being investigated.MethodsWe administered a methanol extract of D. tuberculatus (MED) orally to Lep knockout (KO) mice for 4 weeks to investigate the therapeutic effects on obesity, weight gain, fat accumulation, lipid metabolism, inflammatory response, and β-oxidation.ResultsIn Lep KO mice, MED significantly reduced weight gains, food intake, and total cholesterol and glyceride levels. Similar reductions in fat weights and adipocyte sizes were also observed. Furthermore, MED treatment reduced liver weight, lipid droplet numbers, the expressions of adipogenesis and lipogenesis-related genes, and the expressions of lipolysis regulators in liver tissues. Moreover, the iNOS-mediated COX-2 induction pathway, the inflammasome pathway, and inflammatory cytokine levels were reduced, but β-oxidation was increased, in the livers of MED-treated Lep KO mice.ConclusionThe results of this study suggest that MED ameliorates obesity and has considerable potential as an anti-obesity treatment. |
| first_indexed | 2024-03-13T07:52:24Z |
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| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T07:52:24Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-c3b5323703084fbb8889957d715a4ebe2023-06-02T10:57:47ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-05-011410.3389/fendo.2023.11672851167285Dipterocarpus tuberculatus as a promising anti-obesity treatment in Lep knockout miceYu Jeong Roh0Su Jin Lee1Ji Eun Kim2You Jeong Jin3Ayun Seol4Hee Jin Song5Jumin Park6So Hae Park7Bounleuane Douangdeuane8Onevilay Souliya9Sun Il Choi10Dae Youn Hwang11Dae Youn Hwang12Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang, Republic of KoreaDepartment of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang, Republic of KoreaDepartment of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang, Republic of KoreaDepartment of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang, Republic of KoreaDepartment of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang, Republic of KoreaDepartment of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang, Republic of KoreaDepartment of Food Science and Nutrition, College of Human Ecology, Pusan National University, Busan, Republic of KoreaDepartment of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang, Republic of KoreaInstitute of Traditional Medicine, Ministry of Health, Vientiane, LaosInstitute of Traditional Medicine, Ministry of Health, Vientiane, LaosHenan Key Laboratory of Brain Targeted Bio-Nanomedicine, School of Life Sciences & School of Pharmacy, Henan University, Kaifeng, Henan, ChinaDepartment of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang, Republic of KoreaLongevity Wellbeing Research Center/Laboratory Animals Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang, Republic of KoreaIntroductionThe therapeutic effects and mechanisms of Dipterocarpus tuberculatus (D. tuberculatus) extracts have been examined concerning inflammation, photoaging, and gastritis; however, their effect on obesity is still being investigated.MethodsWe administered a methanol extract of D. tuberculatus (MED) orally to Lep knockout (KO) mice for 4 weeks to investigate the therapeutic effects on obesity, weight gain, fat accumulation, lipid metabolism, inflammatory response, and β-oxidation.ResultsIn Lep KO mice, MED significantly reduced weight gains, food intake, and total cholesterol and glyceride levels. Similar reductions in fat weights and adipocyte sizes were also observed. Furthermore, MED treatment reduced liver weight, lipid droplet numbers, the expressions of adipogenesis and lipogenesis-related genes, and the expressions of lipolysis regulators in liver tissues. Moreover, the iNOS-mediated COX-2 induction pathway, the inflammasome pathway, and inflammatory cytokine levels were reduced, but β-oxidation was increased, in the livers of MED-treated Lep KO mice.ConclusionThe results of this study suggest that MED ameliorates obesity and has considerable potential as an anti-obesity treatment.https://www.frontiersin.org/articles/10.3389/fendo.2023.1167285/fullanti-obesityD. tuberculatuslipogenesislipolysisinflammasomeβ-oxidation |
| spellingShingle | Yu Jeong Roh Su Jin Lee Ji Eun Kim You Jeong Jin Ayun Seol Hee Jin Song Jumin Park So Hae Park Bounleuane Douangdeuane Onevilay Souliya Sun Il Choi Dae Youn Hwang Dae Youn Hwang Dipterocarpus tuberculatus as a promising anti-obesity treatment in Lep knockout mice Frontiers in Endocrinology anti-obesity D. tuberculatus lipogenesis lipolysis inflammasome β-oxidation |
| title | Dipterocarpus tuberculatus as a promising anti-obesity treatment in Lep knockout mice |
| title_full | Dipterocarpus tuberculatus as a promising anti-obesity treatment in Lep knockout mice |
| title_fullStr | Dipterocarpus tuberculatus as a promising anti-obesity treatment in Lep knockout mice |
| title_full_unstemmed | Dipterocarpus tuberculatus as a promising anti-obesity treatment in Lep knockout mice |
| title_short | Dipterocarpus tuberculatus as a promising anti-obesity treatment in Lep knockout mice |
| title_sort | dipterocarpus tuberculatus as a promising anti obesity treatment in lep knockout mice |
| topic | anti-obesity D. tuberculatus lipogenesis lipolysis inflammasome β-oxidation |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1167285/full |
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