APOA5 rs651821 confers increased risk for hypertension in Tongdao Dong population
Hypertension is a complex disease that partially influenced by genetic factors. Up till now, the association between the rs651821 in apolipoprotein A5 (APOA5) gene and hypertension remains unknown. This study was undertaken to investigate the relationship between the APOA5 rs651821 and hypertension...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2019.1590383 |
| _version_ | 1797681323376115712 |
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| author | Haiying Wang Taimei Zhou Huiying He Rong Peng Sujie Wang Xinglin Jiang |
| author_facet | Haiying Wang Taimei Zhou Huiying He Rong Peng Sujie Wang Xinglin Jiang |
| author_sort | Haiying Wang |
| collection | DOAJ |
| description | Hypertension is a complex disease that partially influenced by genetic factors. Up till now, the association between the rs651821 in apolipoprotein A5 (APOA5) gene and hypertension remains unknown. This study was undertaken to investigate the relationship between the APOA5 rs651821 and hypertension in Tongdao Dong population. A total of 274 participants were involved in this study (135 hypertensive patients and 139 nonhypertensive adults). The single nucleotide polymorphism (SNP) was genotyped by using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The results showed that the genotypic and allelic frequencies of rs651821 were significantly different between the normotensives and hypertensive subjects (P = 0.009, P = 0.003 respectively). TC/CC genotypes of rs651821 were associated with an elevated risk of hypertension (TC/CC vs. TT: adjusted odds ratio (AOR) = 1.791, 95%CI = 1.067–3.006, P = 0.009). Besides, the TC/CC genotypes were related to an increased plasma triglyceride (TG) level (TC/CC vs. TT: 2.47 ± 1.91 vs. 1.82 ± 1.07, P = 0.001).The results suggest that the C carriers of APOA5 rs651821 are associated with an increased serum TG concentration and may cause the increased susceptibility of the individual to hypertension in Chinese Dong population. |
| first_indexed | 2024-03-11T23:43:16Z |
| format | Article |
| id | doaj.art-c3b5f01ccab64e9ca1f6a4a73c9c3f6b |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:43:16Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-c3b5f01ccab64e9ca1f6a4a73c9c3f6b2023-09-19T15:19:28ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062020-01-01421818510.1080/10641963.2019.15903831590383APOA5 rs651821 confers increased risk for hypertension in Tongdao Dong populationHaiying Wang0Taimei Zhou1Huiying He2Rong Peng3Sujie Wang4Xinglin Jiang5Hunan University of MedicineHunan University of MedicineHunan University of MedicineHunan University of MedicineHunan University of MedicineHunan University of MedicineHypertension is a complex disease that partially influenced by genetic factors. Up till now, the association between the rs651821 in apolipoprotein A5 (APOA5) gene and hypertension remains unknown. This study was undertaken to investigate the relationship between the APOA5 rs651821 and hypertension in Tongdao Dong population. A total of 274 participants were involved in this study (135 hypertensive patients and 139 nonhypertensive adults). The single nucleotide polymorphism (SNP) was genotyped by using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The results showed that the genotypic and allelic frequencies of rs651821 were significantly different between the normotensives and hypertensive subjects (P = 0.009, P = 0.003 respectively). TC/CC genotypes of rs651821 were associated with an elevated risk of hypertension (TC/CC vs. TT: adjusted odds ratio (AOR) = 1.791, 95%CI = 1.067–3.006, P = 0.009). Besides, the TC/CC genotypes were related to an increased plasma triglyceride (TG) level (TC/CC vs. TT: 2.47 ± 1.91 vs. 1.82 ± 1.07, P = 0.001).The results suggest that the C carriers of APOA5 rs651821 are associated with an increased serum TG concentration and may cause the increased susceptibility of the individual to hypertension in Chinese Dong population.http://dx.doi.org/10.1080/10641963.2019.1590383apoa5snprs651821hypertensionassociation |
| spellingShingle | Haiying Wang Taimei Zhou Huiying He Rong Peng Sujie Wang Xinglin Jiang APOA5 rs651821 confers increased risk for hypertension in Tongdao Dong population Clinical and Experimental Hypertension apoa5 snp rs651821 hypertension association |
| title | APOA5 rs651821 confers increased risk for hypertension in Tongdao Dong population |
| title_full | APOA5 rs651821 confers increased risk for hypertension in Tongdao Dong population |
| title_fullStr | APOA5 rs651821 confers increased risk for hypertension in Tongdao Dong population |
| title_full_unstemmed | APOA5 rs651821 confers increased risk for hypertension in Tongdao Dong population |
| title_short | APOA5 rs651821 confers increased risk for hypertension in Tongdao Dong population |
| title_sort | apoa5 rs651821 confers increased risk for hypertension in tongdao dong population |
| topic | apoa5 snp rs651821 hypertension association |
| url | http://dx.doi.org/10.1080/10641963.2019.1590383 |
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