Analysis of risk characteristics for metachronous metastasis in different period of nasopharyngeal carcinoma
Abstract Objective To identify the main risk factors for metachronous metastatic nasopharyngeal carcinoma (NPC) in different periods after radiotherapy and estimate the weight of various factors in the early or late metachronous metastasis (EMM/LMM) groups. Methods This retrospective registry consis...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-10641-8 |
| _version_ | 1797864447660785664 |
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| author | Zhaodong Fei Huiling Hong Ting Xu Yiying Xu Jiawei Chen Xiufang Qiu Jianming Ding Ye Feng Chaoxiong Huang Li Li Mengying Li Chuanben Chen |
| author_facet | Zhaodong Fei Huiling Hong Ting Xu Yiying Xu Jiawei Chen Xiufang Qiu Jianming Ding Ye Feng Chaoxiong Huang Li Li Mengying Li Chuanben Chen |
| author_sort | Zhaodong Fei |
| collection | DOAJ |
| description | Abstract Objective To identify the main risk factors for metachronous metastatic nasopharyngeal carcinoma (NPC) in different periods after radiotherapy and estimate the weight of various factors in the early or late metachronous metastasis (EMM/LMM) groups. Methods This retrospective registry consists of 4434 patients with newly diagnosed NPC. Cox regression analysis was used to assess the independent significance of various risk factors. The Interactive Risk Attributable Program (IRAP) was used to calculate the attributable risks (ARs) for metastatic patients during different periods. Results Among 514 metastatic patients, 346 (67.32%) patients diagnosed with metastasis within 2 years after treatment were classified into the EMM group, while other 168 patients were classified into the LMM group. The ARs of T-stage, N-stage, pre-Epstein-Barr virus (EBV) DNA, post-EBV DNA, age, sex, pre-neutrophil-to-lymphocyte ratio, pre-platelet-to-lymphocyte ratio, pre-hemoglobin (HB), and post-HB were 20.19, 67.25, 2.81, 14.28, 18.50, - 11.17%, 14.54, 9.60, 3.74% and - 9.79%, respectively, in the EMM group. In the LMM group, the corresponding ARs were 3.68, 49.11, - 18.04%, 2.19, 6.11, 0.36, 4.62, 19.77, 9.57 and 7.76%, respectively. After multivariable adjustment, the total AR for tumor-related factors was 78.19%, and that for patient-related factors was 26.07% in the EMM group. In the LMM group, the total AR of tumor-related factors was 43.85%, while the weights of patient-related factors was 39.97%. In addition, except for these identified tumor- and patient-related factors, other unevaluated factors played a more important role in patients with late metastasis, with the weight increasing by 15.77%, from 17.76% in the EMM group to 33.53% in the LMM group. Conclusion Most metachronous metastatic NPC cases occurred in the first 2 years after treatment. Early metastasis was mainly affected by tumor-related factors, which accounted for a declining percentage in the LMM group. |
| first_indexed | 2024-04-09T22:51:59Z |
| format | Article |
| id | doaj.art-c3b7e0a6998d4bbe9b0d3dcc000c04a3 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-09T22:51:59Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-c3b7e0a6998d4bbe9b0d3dcc000c04a32023-03-22T11:35:10ZengBMCBMC Cancer1471-24072023-02-0123111010.1186/s12885-023-10641-8Analysis of risk characteristics for metachronous metastasis in different period of nasopharyngeal carcinomaZhaodong Fei0Huiling Hong1Ting Xu2Yiying Xu3Jiawei Chen4Xiufang Qiu5Jianming Ding6Ye Feng7Chaoxiong Huang8Li Li9Mengying Li10Chuanben Chen11Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma RoadDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma RoadDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma RoadDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma RoadDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma RoadDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma RoadDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma RoadDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma RoadDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma RoadDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma RoadDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma RoadDepartment of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma RoadAbstract Objective To identify the main risk factors for metachronous metastatic nasopharyngeal carcinoma (NPC) in different periods after radiotherapy and estimate the weight of various factors in the early or late metachronous metastasis (EMM/LMM) groups. Methods This retrospective registry consists of 4434 patients with newly diagnosed NPC. Cox regression analysis was used to assess the independent significance of various risk factors. The Interactive Risk Attributable Program (IRAP) was used to calculate the attributable risks (ARs) for metastatic patients during different periods. Results Among 514 metastatic patients, 346 (67.32%) patients diagnosed with metastasis within 2 years after treatment were classified into the EMM group, while other 168 patients were classified into the LMM group. The ARs of T-stage, N-stage, pre-Epstein-Barr virus (EBV) DNA, post-EBV DNA, age, sex, pre-neutrophil-to-lymphocyte ratio, pre-platelet-to-lymphocyte ratio, pre-hemoglobin (HB), and post-HB were 20.19, 67.25, 2.81, 14.28, 18.50, - 11.17%, 14.54, 9.60, 3.74% and - 9.79%, respectively, in the EMM group. In the LMM group, the corresponding ARs were 3.68, 49.11, - 18.04%, 2.19, 6.11, 0.36, 4.62, 19.77, 9.57 and 7.76%, respectively. After multivariable adjustment, the total AR for tumor-related factors was 78.19%, and that for patient-related factors was 26.07% in the EMM group. In the LMM group, the total AR of tumor-related factors was 43.85%, while the weights of patient-related factors was 39.97%. In addition, except for these identified tumor- and patient-related factors, other unevaluated factors played a more important role in patients with late metastasis, with the weight increasing by 15.77%, from 17.76% in the EMM group to 33.53% in the LMM group. Conclusion Most metachronous metastatic NPC cases occurred in the first 2 years after treatment. Early metastasis was mainly affected by tumor-related factors, which accounted for a declining percentage in the LMM group.https://doi.org/10.1186/s12885-023-10641-8Nasopharyngeal carcinomaDistant metastasisInteractive risk attributable programAttributable risksMetachronous metastatic nasopharyngeal carcinoma |
| spellingShingle | Zhaodong Fei Huiling Hong Ting Xu Yiying Xu Jiawei Chen Xiufang Qiu Jianming Ding Ye Feng Chaoxiong Huang Li Li Mengying Li Chuanben Chen Analysis of risk characteristics for metachronous metastasis in different period of nasopharyngeal carcinoma BMC Cancer Nasopharyngeal carcinoma Distant metastasis Interactive risk attributable program Attributable risks Metachronous metastatic nasopharyngeal carcinoma |
| title | Analysis of risk characteristics for metachronous metastasis in different period of nasopharyngeal carcinoma |
| title_full | Analysis of risk characteristics for metachronous metastasis in different period of nasopharyngeal carcinoma |
| title_fullStr | Analysis of risk characteristics for metachronous metastasis in different period of nasopharyngeal carcinoma |
| title_full_unstemmed | Analysis of risk characteristics for metachronous metastasis in different period of nasopharyngeal carcinoma |
| title_short | Analysis of risk characteristics for metachronous metastasis in different period of nasopharyngeal carcinoma |
| title_sort | analysis of risk characteristics for metachronous metastasis in different period of nasopharyngeal carcinoma |
| topic | Nasopharyngeal carcinoma Distant metastasis Interactive risk attributable program Attributable risks Metachronous metastatic nasopharyngeal carcinoma |
| url | https://doi.org/10.1186/s12885-023-10641-8 |
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