Dysregulation of circular RNAs in inflammation and cancers
Emerging lines of evidence have shown that the production of the covalently closed single-stranded circular RNAs is not splicing errors, but rather a regulated process with distinct biogenesis and turnover. Circular RNAs are expressed in a cell type- and tissue-specific manner and often localize to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2023-09-01
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| Series: | Fundamental Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325823001917 |
| _version_ | 1797676244446216192 |
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| author | Jiayu Liu Fangqing Zhao Ling-Ling Chen Shicheng Su |
| author_facet | Jiayu Liu Fangqing Zhao Ling-Ling Chen Shicheng Su |
| author_sort | Jiayu Liu |
| collection | DOAJ |
| description | Emerging lines of evidence have shown that the production of the covalently closed single-stranded circular RNAs is not splicing errors, but rather a regulated process with distinct biogenesis and turnover. Circular RNAs are expressed in a cell type- and tissue-specific manner and often localize to specific subcellular regions or organelles for functions. The dysregulation of circular RNAs from birth to death is linked to the pathogenesis and progression of diverse diseases. This review outlines how aberrant circular RNA biogenesis, subcellular location, and degradation are linked to disease progression, focusing on metaflammation and cancers. We also discuss potential therapeutic strategies and obstacles in targeting such disease-related circular RNAs. |
| first_indexed | 2024-03-11T22:25:12Z |
| format | Article |
| id | doaj.art-c3b9668af979450c9d24ef4fbfcb0376 |
| institution | Directory Open Access Journal |
| issn | 2667-3258 |
| language | English |
| last_indexed | 2024-03-11T22:25:12Z |
| publishDate | 2023-09-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj.art-c3b9668af979450c9d24ef4fbfcb03762023-09-24T05:17:15ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582023-09-0135683691Dysregulation of circular RNAs in inflammation and cancersJiayu Liu0Fangqing Zhao1Ling-Ling Chen2Shicheng Su3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, ChinaBeijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou 310003, ChinaState Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 200092, China; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou 310003, ChinaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China; Department of Immunology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China; Corresponding author.Emerging lines of evidence have shown that the production of the covalently closed single-stranded circular RNAs is not splicing errors, but rather a regulated process with distinct biogenesis and turnover. Circular RNAs are expressed in a cell type- and tissue-specific manner and often localize to specific subcellular regions or organelles for functions. The dysregulation of circular RNAs from birth to death is linked to the pathogenesis and progression of diverse diseases. This review outlines how aberrant circular RNA biogenesis, subcellular location, and degradation are linked to disease progression, focusing on metaflammation and cancers. We also discuss potential therapeutic strategies and obstacles in targeting such disease-related circular RNAs.http://www.sciencedirect.com/science/article/pii/S2667325823001917Circular RNAMetaflammationBiogenesisDegradationSubcellular localization |
| spellingShingle | Jiayu Liu Fangqing Zhao Ling-Ling Chen Shicheng Su Dysregulation of circular RNAs in inflammation and cancers Fundamental Research Circular RNA Metaflammation Biogenesis Degradation Subcellular localization |
| title | Dysregulation of circular RNAs in inflammation and cancers |
| title_full | Dysregulation of circular RNAs in inflammation and cancers |
| title_fullStr | Dysregulation of circular RNAs in inflammation and cancers |
| title_full_unstemmed | Dysregulation of circular RNAs in inflammation and cancers |
| title_short | Dysregulation of circular RNAs in inflammation and cancers |
| title_sort | dysregulation of circular rnas in inflammation and cancers |
| topic | Circular RNA Metaflammation Biogenesis Degradation Subcellular localization |
| url | http://www.sciencedirect.com/science/article/pii/S2667325823001917 |
| work_keys_str_mv | AT jiayuliu dysregulationofcircularrnasininflammationandcancers AT fangqingzhao dysregulationofcircularrnasininflammationandcancers AT linglingchen dysregulationofcircularrnasininflammationandcancers AT shichengsu dysregulationofcircularrnasininflammationandcancers |