Evidence for Elizabethkingia anophelis Transmission from Mother to Infant, Hong Kong
Elizabethkingia anophelis, recently discovered from mosquito gut, is an emerging bacterium associated with neonatal meningitis and nosocomial outbreaks. However, its transmission route remains unknown. We use rapid genome sequencing to investigate 3 cases of E. anophelis sepsis involving 2 neonates...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2015-02-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/21/2/14-0623_article |
| _version_ | 1818033231380873216 |
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| author | Susanna K.P. Lau Alan K.L. Wu Jade L.L. Teng Herman Tse Shirly O.T. Curreem Stephen K.W. Tsui Yi Huang Jonathan H.K. Chen Rodney A. Lee Patrick C.Y. Woo Kwok-Yung Yuen |
| author_facet | Susanna K.P. Lau Alan K.L. Wu Jade L.L. Teng Herman Tse Shirly O.T. Curreem Stephen K.W. Tsui Yi Huang Jonathan H.K. Chen Rodney A. Lee Patrick C.Y. Woo Kwok-Yung Yuen |
| author_sort | Susanna K.P. Lau |
| collection | DOAJ |
| description | Elizabethkingia anophelis, recently discovered from mosquito gut, is an emerging bacterium associated with neonatal meningitis and nosocomial outbreaks. However, its transmission route remains unknown. We use rapid genome sequencing to investigate 3 cases of E. anophelis sepsis involving 2 neonates who had meningitis and 1 neonate’s mother who had chorioamnionitis. Comparative genomics revealed evidence for perinatal vertical transmission from a mother to her neonate; the 2 isolates from these patients, HKU37 and HKU38, shared essentially identical genome sequences. In contrast, the strain from another neonate (HKU36) was genetically divergent, showing only 78.6% genome sequence identity to HKU37 and HKU38, thus excluding a clonal outbreak. Comparison to genomes from mosquito strains revealed potential metabolic adaptations in E. anophelis under different environments. Maternal infection, not mosquitoes, is most likely the source of neonatal E. anophelis infections. Our findings highlight the power of genome sequencing in gaining rapid insights on transmission and pathogenesis of emerging pathogens. |
| first_indexed | 2024-12-10T06:19:59Z |
| format | Article |
| id | doaj.art-c3ba2ef7daa744c1bcbd12c415e5dc19 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-10T06:19:59Z |
| publishDate | 2015-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-c3ba2ef7daa744c1bcbd12c415e5dc192022-12-22T01:59:22ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592015-02-0121223224110.3201/eid2102.140623Evidence for Elizabethkingia anophelis Transmission from Mother to Infant, Hong KongSusanna K.P. LauAlan K.L. WuJade L.L. TengHerman TseShirly O.T. CurreemStephen K.W. TsuiYi HuangJonathan H.K. ChenRodney A. LeePatrick C.Y. WooKwok-Yung YuenElizabethkingia anophelis, recently discovered from mosquito gut, is an emerging bacterium associated with neonatal meningitis and nosocomial outbreaks. However, its transmission route remains unknown. We use rapid genome sequencing to investigate 3 cases of E. anophelis sepsis involving 2 neonates who had meningitis and 1 neonate’s mother who had chorioamnionitis. Comparative genomics revealed evidence for perinatal vertical transmission from a mother to her neonate; the 2 isolates from these patients, HKU37 and HKU38, shared essentially identical genome sequences. In contrast, the strain from another neonate (HKU36) was genetically divergent, showing only 78.6% genome sequence identity to HKU37 and HKU38, thus excluding a clonal outbreak. Comparison to genomes from mosquito strains revealed potential metabolic adaptations in E. anophelis under different environments. Maternal infection, not mosquitoes, is most likely the source of neonatal E. anophelis infections. Our findings highlight the power of genome sequencing in gaining rapid insights on transmission and pathogenesis of emerging pathogens.https://wwwnc.cdc.gov/eid/article/21/2/14-0623_articlegenomeElizabethkingia anophelisneonatalmeningitissepsisvertical |
| spellingShingle | Susanna K.P. Lau Alan K.L. Wu Jade L.L. Teng Herman Tse Shirly O.T. Curreem Stephen K.W. Tsui Yi Huang Jonathan H.K. Chen Rodney A. Lee Patrick C.Y. Woo Kwok-Yung Yuen Evidence for Elizabethkingia anophelis Transmission from Mother to Infant, Hong Kong Emerging Infectious Diseases genome Elizabethkingia anophelis neonatal meningitis sepsis vertical |
| title | Evidence for Elizabethkingia anophelis Transmission from Mother to Infant, Hong Kong |
| title_full | Evidence for Elizabethkingia anophelis Transmission from Mother to Infant, Hong Kong |
| title_fullStr | Evidence for Elizabethkingia anophelis Transmission from Mother to Infant, Hong Kong |
| title_full_unstemmed | Evidence for Elizabethkingia anophelis Transmission from Mother to Infant, Hong Kong |
| title_short | Evidence for Elizabethkingia anophelis Transmission from Mother to Infant, Hong Kong |
| title_sort | evidence for elizabethkingia anophelis transmission from mother to infant hong kong |
| topic | genome Elizabethkingia anophelis neonatal meningitis sepsis vertical |
| url | https://wwwnc.cdc.gov/eid/article/21/2/14-0623_article |
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