HIF and MYC signaling in adrenal neoplasms of the neural crest: implications for pediatrics

HIF and MYC signaling in adrenal neoplasms of the neural crest: implications for pediatrics

Pediatric neural crest-derived adrenal neoplasms include neuroblastoma and pheochromocytoma. Both entities are associated with a high degree of clinical heterogeneity, varying from spontaneous regression to malignant disease with poor outcome. Increased expression and stabilization of HIF2α appears...

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Bibliographic Details
Main Authors: Nicole Bechmann, Frank Westermann, Graeme Eisenhofer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Endocrinology
Subjects:
pheochromocytoma
neuroblastoma
catecholamines
sympathoadrenal cell lineage
hypoxia
MYC
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1022192/full

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