Altered functional connectivity of primary visual cortex in adults with strabismus and amblyopia: a resting-state fMRI study
Functional connectivity of the primary visual cortex was explored with resting functional magnetic resonance imaging among adults with strabismus and amblyopia and healthy controls. We used the two-sample test and receiver operating characteristic curves to investigate the differences in mean fun...
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| Format: | Article |
| Language: | English |
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IMR Press
2022-01-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://article.imrpress.com/journal/JIN/21/1/10.31083/j.jin2101004/1757-448X-21-1-004.pdf |
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| author | Li-Qi Liu Qiu-Yu Li Zhi-Hua Zhang Shi-Nan Wu Hui-Ye Shu Li-Juan Zhang Rong-Bin Liang Yi-Cong Pan Yi Shao |
| author_facet | Li-Qi Liu Qiu-Yu Li Zhi-Hua Zhang Shi-Nan Wu Hui-Ye Shu Li-Juan Zhang Rong-Bin Liang Yi-Cong Pan Yi Shao |
| author_sort | Li-Qi Liu |
| collection | DOAJ |
| description | Functional connectivity of the primary visual cortex was explored with resting
functional magnetic resonance imaging among adults with strabismus and amblyopia
and healthy controls. We used the two-sample test and receiver operating
characteristic curves to investigate the differences in mean functional
connectivity values between the groups with strabismus and amblyopia and healthy
controls. Compared with healthy controls, functional connectivity values in the
left Brodmann areas 17, including bilateral lingual/angular gyri, were reduced in
groups with strabismus and amblyopia. Moreover, functional connectivity values in
the right Brodmann area 17, including left cuneus, right inferior occipital
gyrus, and left inferior parietal lobule, were reduced in adults with strabismus
and amblyopia. Our findings indicate that functional connectivity abnormalities
exist between the primary visual cortex and other regions. This may be the basis
of the pathological mechanism of visual dysfunction and stereovision disorders in
adults with strabismus and amblyopia. |
| first_indexed | 2024-04-13T04:27:58Z |
| format | Article |
| id | doaj.art-c3c14222a60646478b1379c98b1feeb9 |
| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-04-13T04:27:58Z |
| publishDate | 2022-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-c3c14222a60646478b1379c98b1feeb92022-12-22T03:02:25ZengIMR PressJournal of Integrative Neuroscience0219-63522022-01-0121100410.31083/j.jin2101004S0219-6352(22)00264-9Altered functional connectivity of primary visual cortex in adults with strabismus and amblyopia: a resting-state fMRI studyLi-Qi Liu0Qiu-Yu Li1Zhi-Hua Zhang2Shi-Nan Wu3Hui-Ye Shu4Li-Juan Zhang5Rong-Bin Liang6Yi-Cong Pan7Yi Shao8Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaFunctional connectivity of the primary visual cortex was explored with resting functional magnetic resonance imaging among adults with strabismus and amblyopia and healthy controls. We used the two-sample test and receiver operating characteristic curves to investigate the differences in mean functional connectivity values between the groups with strabismus and amblyopia and healthy controls. Compared with healthy controls, functional connectivity values in the left Brodmann areas 17, including bilateral lingual/angular gyri, were reduced in groups with strabismus and amblyopia. Moreover, functional connectivity values in the right Brodmann area 17, including left cuneus, right inferior occipital gyrus, and left inferior parietal lobule, were reduced in adults with strabismus and amblyopia. Our findings indicate that functional connectivity abnormalities exist between the primary visual cortex and other regions. This may be the basis of the pathological mechanism of visual dysfunction and stereovision disorders in adults with strabismus and amblyopia.https://article.imrpress.com/journal/JIN/21/1/10.31083/j.jin2101004/1757-448X-21-1-004.pdfstrabismusamblyopiafunctional connectivityprimary visual cortexspontaneous activityresting fmrineuropathologyophthalmopathy |
| spellingShingle | Li-Qi Liu Qiu-Yu Li Zhi-Hua Zhang Shi-Nan Wu Hui-Ye Shu Li-Juan Zhang Rong-Bin Liang Yi-Cong Pan Yi Shao Altered functional connectivity of primary visual cortex in adults with strabismus and amblyopia: a resting-state fMRI study Journal of Integrative Neuroscience strabismus amblyopia functional connectivity primary visual cortex spontaneous activity resting fmri neuropathology ophthalmopathy |
| title | Altered functional connectivity of primary visual cortex in adults with strabismus and amblyopia: a resting-state fMRI study |
| title_full | Altered functional connectivity of primary visual cortex in adults with strabismus and amblyopia: a resting-state fMRI study |
| title_fullStr | Altered functional connectivity of primary visual cortex in adults with strabismus and amblyopia: a resting-state fMRI study |
| title_full_unstemmed | Altered functional connectivity of primary visual cortex in adults with strabismus and amblyopia: a resting-state fMRI study |
| title_short | Altered functional connectivity of primary visual cortex in adults with strabismus and amblyopia: a resting-state fMRI study |
| title_sort | altered functional connectivity of primary visual cortex in adults with strabismus and amblyopia a resting state fmri study |
| topic | strabismus amblyopia functional connectivity primary visual cortex spontaneous activity resting fmri neuropathology ophthalmopathy |
| url | https://article.imrpress.com/journal/JIN/21/1/10.31083/j.jin2101004/1757-448X-21-1-004.pdf |
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