When a T cell engages a B cell: novel insights in multiple sclerosis
Multiple sclerosis is an autoimmune disease of the central nervous system (CNS) in which autoreactive T cells are considered to be the major effector cells in orchestrating and promoting CNS injuries. However, B cells emerged as additional important cellular player in multiple sclerosis immunopath...
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2020-08-01
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| Series: | Swiss Medical Weekly |
| Subjects: | |
| Online Access: | https://www.smw.ch/index.php/smw/article/view/2866 |
| _version_ | 1797974861645086720 |
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| author | Ivan Jelcic Mireia Sospedra Roland Martin |
| author_facet | Ivan Jelcic Mireia Sospedra Roland Martin |
| author_sort | Ivan Jelcic |
| collection | DOAJ |
| description |
Multiple sclerosis is an autoimmune disease of the central nervous system (CNS) in which autoreactive T cells are considered to be the major effector cells in orchestrating and promoting CNS injuries. However, B cells emerged as additional important cellular player in multiple sclerosis immunopathogenesis since B cell depletion therapy has been found to be very effective in reducing new relapses. This short review summarises important new insights into the interaction between these two cell populations and outlines recent observations regarding how memory B cells activate brain-homing autoreactive T cells in multiple sclerosis.
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| first_indexed | 2024-04-11T04:26:24Z |
| format | Article |
| id | doaj.art-c3c2c10afd994b6aa4814e69e7730058 |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2024-04-11T04:26:24Z |
| publishDate | 2020-08-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-c3c2c10afd994b6aa4814e69e77300582022-12-29T16:02:31ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972020-08-01150353610.4414/smw.2020.20330When a T cell engages a B cell: novel insights in multiple sclerosisIvan JelcicMireia SospedraRoland Martin Multiple sclerosis is an autoimmune disease of the central nervous system (CNS) in which autoreactive T cells are considered to be the major effector cells in orchestrating and promoting CNS injuries. However, B cells emerged as additional important cellular player in multiple sclerosis immunopathogenesis since B cell depletion therapy has been found to be very effective in reducing new relapses. This short review summarises important new insights into the interaction between these two cell populations and outlines recent observations regarding how memory B cells activate brain-homing autoreactive T cells in multiple sclerosis. https://www.smw.ch/index.php/smw/article/view/2866Multiple sclerosisautoimmunityT cellsB cellsHLAautoproliferation |
| spellingShingle | Ivan Jelcic Mireia Sospedra Roland Martin When a T cell engages a B cell: novel insights in multiple sclerosis Swiss Medical Weekly Multiple sclerosis autoimmunity T cells B cells HLA autoproliferation |
| title | When a T cell engages a B cell: novel insights in multiple sclerosis |
| title_full | When a T cell engages a B cell: novel insights in multiple sclerosis |
| title_fullStr | When a T cell engages a B cell: novel insights in multiple sclerosis |
| title_full_unstemmed | When a T cell engages a B cell: novel insights in multiple sclerosis |
| title_short | When a T cell engages a B cell: novel insights in multiple sclerosis |
| title_sort | when a t cell engages a b cell novel insights in multiple sclerosis |
| topic | Multiple sclerosis autoimmunity T cells B cells HLA autoproliferation |
| url | https://www.smw.ch/index.php/smw/article/view/2866 |
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