Amelioration of Cancer Employing Chitosan, Its Derivatives, and Chitosan-Based Nanoparticles: Recent Updates
The limitations associated with the conventional treatment of cancer have necessitated the design and development of novel drug delivery systems based mainly on nanotechnology. These novel drug delivery systems include various kinds of nanoparticles, such as polymeric nanoparticles, solid lipid nano...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/13/2928 |
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| author | Tarun Virmani Girish Kumar Ashwani Sharma Kamla Pathak Md Sayeed Akhtar Obaid Afzal Abdulmalik S. A. Altamimi |
| author_facet | Tarun Virmani Girish Kumar Ashwani Sharma Kamla Pathak Md Sayeed Akhtar Obaid Afzal Abdulmalik S. A. Altamimi |
| author_sort | Tarun Virmani |
| collection | DOAJ |
| description | The limitations associated with the conventional treatment of cancer have necessitated the design and development of novel drug delivery systems based mainly on nanotechnology. These novel drug delivery systems include various kinds of nanoparticles, such as polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, hydrogels, and polymeric micelles. Among the various kinds of novel drug delivery systems, chitosan-based nanoparticles have attracted the attention of researchers to treat cancer. Chitosan is a polycationic polymer generated from chitin with various characteristics such as biocompatibility, biodegradability, non-toxicity, and mucoadhesiveness, making it an ideal polymer to fabricate drug delivery systems. However, chitosan is poorly soluble in water and soluble in acidic aqueous solutions. Furthermore, owing to the presence of reactive amino groups, chitosan can be chemically modified to improve its physiochemical properties. Chitosan and its modified derivatives can be employed to fabricate nanoparticles, which are used most frequently in the pharmaceutical sector due to their possession of various characteristics such as nanosize, appropriate pharmacokinetic and pharmacodynamic properties, non-immunogenicity, improved stability, and improved drug loading capacity. Furthermore, it is capable of delivering nucleic acids, chemotherapeutic medicines, and bioactives using modified chitosan. Chitosan and its modified derivative-based nanoparticles can be targeted to specific cancer sites via active and passive mechanisms. Based on chitosan drug delivery systems, many anticancer drugs now have better effectiveness, potency, cytotoxicity, or biocompatibility. The characteristics of chitosan and its chemically tailored derivatives, as well as their use in cancer therapy, will be examined in this review. |
| first_indexed | 2024-03-11T01:30:41Z |
| format | Article |
| id | doaj.art-c3c3089ee69341e58389a29415eee88f |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T01:30:41Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-c3c3089ee69341e58389a29415eee88f2023-11-18T17:22:12ZengMDPI AGPolymers2073-43602023-07-011513292810.3390/polym15132928Amelioration of Cancer Employing Chitosan, Its Derivatives, and Chitosan-Based Nanoparticles: Recent UpdatesTarun Virmani0Girish Kumar1Ashwani Sharma2Kamla Pathak3Md Sayeed Akhtar4Obaid Afzal5Abdulmalik S. A. Altamimi6School of Pharmaceutical Sciences, MVN University, Haryana 121105, IndiaSchool of Pharmaceutical Sciences, MVN University, Haryana 121105, IndiaSchool of Pharmaceutical Sciences, MVN University, Haryana 121105, IndiaFaculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Etawah 206001, IndiaDepartment of Clinical Pharmacy, College of Pharmacy, King Khalid University, AlFara, Abha 62223, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi ArabiaThe limitations associated with the conventional treatment of cancer have necessitated the design and development of novel drug delivery systems based mainly on nanotechnology. These novel drug delivery systems include various kinds of nanoparticles, such as polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, hydrogels, and polymeric micelles. Among the various kinds of novel drug delivery systems, chitosan-based nanoparticles have attracted the attention of researchers to treat cancer. Chitosan is a polycationic polymer generated from chitin with various characteristics such as biocompatibility, biodegradability, non-toxicity, and mucoadhesiveness, making it an ideal polymer to fabricate drug delivery systems. However, chitosan is poorly soluble in water and soluble in acidic aqueous solutions. Furthermore, owing to the presence of reactive amino groups, chitosan can be chemically modified to improve its physiochemical properties. Chitosan and its modified derivatives can be employed to fabricate nanoparticles, which are used most frequently in the pharmaceutical sector due to their possession of various characteristics such as nanosize, appropriate pharmacokinetic and pharmacodynamic properties, non-immunogenicity, improved stability, and improved drug loading capacity. Furthermore, it is capable of delivering nucleic acids, chemotherapeutic medicines, and bioactives using modified chitosan. Chitosan and its modified derivative-based nanoparticles can be targeted to specific cancer sites via active and passive mechanisms. Based on chitosan drug delivery systems, many anticancer drugs now have better effectiveness, potency, cytotoxicity, or biocompatibility. The characteristics of chitosan and its chemically tailored derivatives, as well as their use in cancer therapy, will be examined in this review.https://www.mdpi.com/2073-4360/15/13/2928chitosanmodified chitosanbiopolymerchitosan nanoparticlescancerpatent |
| spellingShingle | Tarun Virmani Girish Kumar Ashwani Sharma Kamla Pathak Md Sayeed Akhtar Obaid Afzal Abdulmalik S. A. Altamimi Amelioration of Cancer Employing Chitosan, Its Derivatives, and Chitosan-Based Nanoparticles: Recent Updates Polymers chitosan modified chitosan biopolymer chitosan nanoparticles cancer patent |
| title | Amelioration of Cancer Employing Chitosan, Its Derivatives, and Chitosan-Based Nanoparticles: Recent Updates |
| title_full | Amelioration of Cancer Employing Chitosan, Its Derivatives, and Chitosan-Based Nanoparticles: Recent Updates |
| title_fullStr | Amelioration of Cancer Employing Chitosan, Its Derivatives, and Chitosan-Based Nanoparticles: Recent Updates |
| title_full_unstemmed | Amelioration of Cancer Employing Chitosan, Its Derivatives, and Chitosan-Based Nanoparticles: Recent Updates |
| title_short | Amelioration of Cancer Employing Chitosan, Its Derivatives, and Chitosan-Based Nanoparticles: Recent Updates |
| title_sort | amelioration of cancer employing chitosan its derivatives and chitosan based nanoparticles recent updates |
| topic | chitosan modified chitosan biopolymer chitosan nanoparticles cancer patent |
| url | https://www.mdpi.com/2073-4360/15/13/2928 |
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