Timing of initial surfactant treatment in very low birth weight newborns
Objective: To correlate the timing of treatment using exogenous surfactant with the main variables related to respiratory distress syndrome or prematurity. Methods: A historic cohort study between January 1, 2004 and June 30, 2007, including very low birth weight newborns (birth weight <1,500 g)...
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| Format: | Article |
| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2010-09-01
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| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://apps.einstein.br/revista/arquivos/PDF/1758-Einsteinv8n3_pg320-4_eng.pdf |
| _version_ | 1818986870823976960 |
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| author | Celso Moura Rebello Luciene Ferreira do Amaral Nacif Alice D´Agostini Deutsch Ângela Tavares Paes |
| author_facet | Celso Moura Rebello Luciene Ferreira do Amaral Nacif Alice D´Agostini Deutsch Ângela Tavares Paes |
| author_sort | Celso Moura Rebello |
| collection | DOAJ |
| description | Objective: To correlate the timing of treatment using exogenous surfactant with the main variables related to respiratory distress syndrome or prematurity. Methods: A historic cohort study between January 1, 2004 and June 30, 2007, including very low birth weight newborns (birth weight <1,500 g) admitted to the hospital and who required surfactant therapy. Newborns were divided into three study groups: early (treatment during the first two hours); intermediate (treatment between two and six hours) and late (treatment after six hours). Variables analyzed were: air leak syndrome, mortality, bronchopulmonary dysplasia, intracranial hemorrhage, patent ductus arteriosus, retinopathy of prematurity, duration of oxygen therapy, duration of mechanical ventilation, length of hospital stay and number of surfactant doses. Results: A total of 63 newborns were included (Early Group, n = 21; Intermediate Group, n = 26 and Late Group, n = 16), there was a statistical significance between birth weight and gestational age. Multivariate logistic regression analysis was used to compensate the effects of gestational age, birth weight and other possible interferences over the variables. This analysis revealed a greater incidence of air leak syndrome among newborns of the Early Group compared to the Intermediate Group (OR = 6.98; 95%CI = 1.24-39.37; p = 0.028), with no difference compared to the Late Group (OR = 3.72; 95% CI = 0.28-49.76; p = 0.321). There were no differences regarding the other variables analyzed. Conclusions: In this retrospective, non-randomized study, surfactant administration during the first two hours of life enhanced the risk of air leak syndrome, compared to the treatment between two and six hours after birth, with no reduction of early or late neonatal mortality or bronchopulmonary dysplasia, compared to later treatment after birth. |
| first_indexed | 2024-12-20T18:57:40Z |
| format | Article |
| id | doaj.art-c3c50d3dff7245678557c4ae8de9a13f |
| institution | Directory Open Access Journal |
| issn | 1679-4508 |
| language | English |
| last_indexed | 2024-12-20T18:57:40Z |
| publishDate | 2010-09-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-c3c50d3dff7245678557c4ae8de9a13f2022-12-21T19:29:28ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)1679-45082010-09-0183320324Timing of initial surfactant treatment in very low birth weight newbornsCelso Moura RebelloLuciene Ferreira do Amaral NacifAlice D´Agostini DeutschÂngela Tavares PaesObjective: To correlate the timing of treatment using exogenous surfactant with the main variables related to respiratory distress syndrome or prematurity. Methods: A historic cohort study between January 1, 2004 and June 30, 2007, including very low birth weight newborns (birth weight <1,500 g) admitted to the hospital and who required surfactant therapy. Newborns were divided into three study groups: early (treatment during the first two hours); intermediate (treatment between two and six hours) and late (treatment after six hours). Variables analyzed were: air leak syndrome, mortality, bronchopulmonary dysplasia, intracranial hemorrhage, patent ductus arteriosus, retinopathy of prematurity, duration of oxygen therapy, duration of mechanical ventilation, length of hospital stay and number of surfactant doses. Results: A total of 63 newborns were included (Early Group, n = 21; Intermediate Group, n = 26 and Late Group, n = 16), there was a statistical significance between birth weight and gestational age. Multivariate logistic regression analysis was used to compensate the effects of gestational age, birth weight and other possible interferences over the variables. This analysis revealed a greater incidence of air leak syndrome among newborns of the Early Group compared to the Intermediate Group (OR = 6.98; 95%CI = 1.24-39.37; p = 0.028), with no difference compared to the Late Group (OR = 3.72; 95% CI = 0.28-49.76; p = 0.321). There were no differences regarding the other variables analyzed. Conclusions: In this retrospective, non-randomized study, surfactant administration during the first two hours of life enhanced the risk of air leak syndrome, compared to the treatment between two and six hours after birth, with no reduction of early or late neonatal mortality or bronchopulmonary dysplasia, compared to later treatment after birth.http://apps.einstein.br/revista/arquivos/PDF/1758-Einsteinv8n3_pg320-4_eng.pdfPulmonary surfactantsInfantprematureInfantnewbornPneumothorax |
| spellingShingle | Celso Moura Rebello Luciene Ferreira do Amaral Nacif Alice D´Agostini Deutsch Ângela Tavares Paes Timing of initial surfactant treatment in very low birth weight newborns Einstein (São Paulo) Pulmonary surfactants Infant premature Infant newborn Pneumothorax |
| title | Timing of initial surfactant treatment in very low birth weight newborns |
| title_full | Timing of initial surfactant treatment in very low birth weight newborns |
| title_fullStr | Timing of initial surfactant treatment in very low birth weight newborns |
| title_full_unstemmed | Timing of initial surfactant treatment in very low birth weight newborns |
| title_short | Timing of initial surfactant treatment in very low birth weight newborns |
| title_sort | timing of initial surfactant treatment in very low birth weight newborns |
| topic | Pulmonary surfactants Infant premature Infant newborn Pneumothorax |
| url | http://apps.einstein.br/revista/arquivos/PDF/1758-Einsteinv8n3_pg320-4_eng.pdf |
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