Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity

Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity

How functionally diverse populations of pathogen-specific killer T cells are generated during an immune response remains unclear. Here, we propose that fine-tuning of CD8αβ co-receptor levels via histone acetylation plays a role in lineage fate. We show that lysine acetyltransferase 6A (KAT6A) is re...

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Bibliographic Details
Main Authors: Dane M. Newman, Shinya Sakaguchi, Aaron Lun, Simon Preston, Marc Pellegrini, Kseniya Khamina, Andreas Bergthaler, Stephen L. Nutt, Gordon K. Smyth, Anne K. Voss, Tim Thomas, Wilfried Ellmeier, Gabrielle T. Belz, Rhys S. Allan
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
T cells
virus
memory
histone acetylation
epigenetic
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716311378

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