Adherence to and Forgiveness of 3TC/DTG in a Real-World Cohort
Background: adherence and forgiveness are key factors for virologic success. We evaluated them for 3TC/DTG. Methods: pharmacy refills were used to calculate the proportion of days covered (PDC). Forgiveness was calculated as the achieved rate of HIV-RNA threshold by a given level of imperfect adhere...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-06-01
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| Series: | Journal of the International Association of Providers of AIDS Care |
| Online Access: | https://doi.org/10.1177/23259582221101815 |
| _version_ | 1818470377079177216 |
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| author | Franco Maggiolo Daniela Valenti Rodolfo Teocchi Laura Comi Elisa Di Filippo Marco Rizzi |
| author_facet | Franco Maggiolo Daniela Valenti Rodolfo Teocchi Laura Comi Elisa Di Filippo Marco Rizzi |
| author_sort | Franco Maggiolo |
| collection | DOAJ |
| description | Background: adherence and forgiveness are key factors for virologic success. We evaluated them for 3TC/DTG. Methods: pharmacy refills were used to calculate the proportion of days covered (PDC). Forgiveness was calculated as the achieved rate of HIV-RNA threshold by a given level of imperfect adherence. Results: 240 PLWH were included. The median follow-up was 819 days (IQR 450-1459) for a total of 681 person/years of follow-up. Adherence was very high with a median of 99% (IQR 95%-100%). Consequently, the virologic response was sustained with 83.8% of PLWH never exceeding a HIV RNA of 50 copies/ml and 95.8% of subjects with a steadily HIV-RNA < 200 copies/ml. A PDC lower than 80% was associated with a negative outcome irrespective of the HIV-RNA threshold considered. Conclusions: The extensive virologic efficacy of 3TC/DTG demonstrated both in clinical trials and real-world experiences seems to rely more on its friendliness than on its forgiveness. |
| first_indexed | 2024-04-13T21:36:26Z |
| format | Article |
| id | doaj.art-c3c5ba422ca440cea0b38f13df2ff4e4 |
| institution | Directory Open Access Journal |
| issn | 2325-9582 |
| language | English |
| last_indexed | 2024-04-13T21:36:26Z |
| publishDate | 2022-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of the International Association of Providers of AIDS Care |
| spelling | doaj.art-c3c5ba422ca440cea0b38f13df2ff4e42022-12-22T02:28:57ZengSAGE PublishingJournal of the International Association of Providers of AIDS Care2325-95822022-06-012110.1177/23259582221101815Adherence to and Forgiveness of 3TC/DTG in a Real-World CohortFranco Maggiolo0Daniela Valenti1Rodolfo Teocchi2Laura Comi3Elisa Di Filippo4Marco Rizzi5 UOC Infectious Diseases, , Bergamo Italy FROM foundation, ASST Papa Giovanni XXII, Bergamo Italy Informatics department, ASST Papa Giovanni XXII, Bergamo Italy UOC Infectious Diseases, , Bergamo Italy UOC Infectious Diseases, , Bergamo Italy UOC Infectious Diseases, , Bergamo ItalyBackground: adherence and forgiveness are key factors for virologic success. We evaluated them for 3TC/DTG. Methods: pharmacy refills were used to calculate the proportion of days covered (PDC). Forgiveness was calculated as the achieved rate of HIV-RNA threshold by a given level of imperfect adherence. Results: 240 PLWH were included. The median follow-up was 819 days (IQR 450-1459) for a total of 681 person/years of follow-up. Adherence was very high with a median of 99% (IQR 95%-100%). Consequently, the virologic response was sustained with 83.8% of PLWH never exceeding a HIV RNA of 50 copies/ml and 95.8% of subjects with a steadily HIV-RNA < 200 copies/ml. A PDC lower than 80% was associated with a negative outcome irrespective of the HIV-RNA threshold considered. Conclusions: The extensive virologic efficacy of 3TC/DTG demonstrated both in clinical trials and real-world experiences seems to rely more on its friendliness than on its forgiveness.https://doi.org/10.1177/23259582221101815 |
| spellingShingle | Franco Maggiolo Daniela Valenti Rodolfo Teocchi Laura Comi Elisa Di Filippo Marco Rizzi Adherence to and Forgiveness of 3TC/DTG in a Real-World Cohort Journal of the International Association of Providers of AIDS Care |
| title | Adherence to and Forgiveness
of 3TC/DTG in a Real-World Cohort |
| title_full | Adherence to and Forgiveness
of 3TC/DTG in a Real-World Cohort |
| title_fullStr | Adherence to and Forgiveness
of 3TC/DTG in a Real-World Cohort |
| title_full_unstemmed | Adherence to and Forgiveness
of 3TC/DTG in a Real-World Cohort |
| title_short | Adherence to and Forgiveness
of 3TC/DTG in a Real-World Cohort |
| title_sort | adherence to and forgiveness of 3tc dtg in a real world cohort |
| url | https://doi.org/10.1177/23259582221101815 |
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