A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis: Protocol Description and Preliminary Results
Patients with familial adenomatous polyposis (FAP) depend on a lifelong endoscopic surveillance programme and prophylactic surgery, and usually suffer nutritional problems. Intestinal inflammation has been linked to both FAP and colorectal cancer. Epidemiological studies show a relationship between...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-05-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/1534735419846400 |
| _version_ | 1819071655395196928 |
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| author | Patrizia Pasanisi Manuela Gariboldi Paolo Verderio Stefano Signoroni Andrea Mancini Licia Rivoltini Massimo Milione Enzo Masci Chiara Maura Ciniselli Eleonora Bruno Alessandra Macciotta Antonino Belfiore Maria Teresa Ricci Giuliana Gargano Daniele Morelli Giovanni Apolone Marco Vitellaro |
| author_facet | Patrizia Pasanisi Manuela Gariboldi Paolo Verderio Stefano Signoroni Andrea Mancini Licia Rivoltini Massimo Milione Enzo Masci Chiara Maura Ciniselli Eleonora Bruno Alessandra Macciotta Antonino Belfiore Maria Teresa Ricci Giuliana Gargano Daniele Morelli Giovanni Apolone Marco Vitellaro |
| author_sort | Patrizia Pasanisi |
| collection | DOAJ |
| description | Patients with familial adenomatous polyposis (FAP) depend on a lifelong endoscopic surveillance programme and prophylactic surgery, and usually suffer nutritional problems. Intestinal inflammation has been linked to both FAP and colorectal cancer. Epidemiological studies show a relationship between diet and inflammation. Preventive dietary recommendations for FAP patients are so far lacking. We have designed a nonrandomized prospective pilot study on FAP patients to assess whether a low-inflammatory diet based on the Mediterranean diet principles and recipes, by interacting with the microbiota, reduces gastrointestinal markers of inflammation and improves quality of life. This report describes the scientific protocol of the study and reports the participants’ adherence to the proposed dietary recommendations. Thirty-four FAP patients older than 18 years, bearing the APC pathogenic variant, who underwent prophylactic total colectomy with ileo-rectal anastomosis were eligible into the study. During the 3-month dietary intervention, they reported improvements in their consumption of Mediterranean foods (vegetables, fruits, fish, and legumes), and a reduction in pro-inflammatory foods (red/processed meat and sweets); this led to a significant increase in their adherence to the Mediterranean diet. The improvement was accompanied by a decrease in the number of diarrhoeal discharges. These preliminary results are encouraging with regard to feasibility, dietary outcome measures, and safety. |
| first_indexed | 2024-12-21T17:25:17Z |
| format | Article |
| id | doaj.art-c3c6cab373c44deba71c7dd67ae05cb7 |
| institution | Directory Open Access Journal |
| issn | 1552-695X |
| language | English |
| last_indexed | 2024-12-21T17:25:17Z |
| publishDate | 2019-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-c3c6cab373c44deba71c7dd67ae05cb72022-12-21T18:56:04ZengSAGE PublishingIntegrative Cancer Therapies1552-695X2019-05-011810.1177/1534735419846400A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis: Protocol Description and Preliminary ResultsPatrizia Pasanisi0Manuela Gariboldi1Paolo Verderio2Stefano Signoroni3Andrea Mancini4Licia Rivoltini5Massimo Milione6Enzo Masci7Chiara Maura Ciniselli8Eleonora Bruno9Alessandra Macciotta10Antonino Belfiore11Maria Teresa Ricci12Giuliana Gargano13Daniele Morelli14Giovanni Apolone15Marco Vitellaro16Unit of Epidemiology and Prevention, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyUnit of Tumor Genomics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyUnit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyUnit of Hereditary Digestive Tract Tumors, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyUnit of Diagnostic and Therapeutic Endoscopy, Fondazione IRCCS Istituto Nazionale Tumori, Milan, ItalyUnit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyUnit of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyUnit of Diagnostic and Therapeutic Endoscopy, Fondazione IRCCS Istituto Nazionale Tumori, Milan, ItalyUnit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyUnit of Epidemiology and Prevention, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyUnit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyUnit of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyUnit of Hereditary Digestive Tract Tumors, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyUnit of Epidemiology and Prevention, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyDepartment of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, ItalyScientific Directorate, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyUnit of Colorectal Surgery, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyPatients with familial adenomatous polyposis (FAP) depend on a lifelong endoscopic surveillance programme and prophylactic surgery, and usually suffer nutritional problems. Intestinal inflammation has been linked to both FAP and colorectal cancer. Epidemiological studies show a relationship between diet and inflammation. Preventive dietary recommendations for FAP patients are so far lacking. We have designed a nonrandomized prospective pilot study on FAP patients to assess whether a low-inflammatory diet based on the Mediterranean diet principles and recipes, by interacting with the microbiota, reduces gastrointestinal markers of inflammation and improves quality of life. This report describes the scientific protocol of the study and reports the participants’ adherence to the proposed dietary recommendations. Thirty-four FAP patients older than 18 years, bearing the APC pathogenic variant, who underwent prophylactic total colectomy with ileo-rectal anastomosis were eligible into the study. During the 3-month dietary intervention, they reported improvements in their consumption of Mediterranean foods (vegetables, fruits, fish, and legumes), and a reduction in pro-inflammatory foods (red/processed meat and sweets); this led to a significant increase in their adherence to the Mediterranean diet. The improvement was accompanied by a decrease in the number of diarrhoeal discharges. These preliminary results are encouraging with regard to feasibility, dietary outcome measures, and safety.https://doi.org/10.1177/1534735419846400 |
| spellingShingle | Patrizia Pasanisi Manuela Gariboldi Paolo Verderio Stefano Signoroni Andrea Mancini Licia Rivoltini Massimo Milione Enzo Masci Chiara Maura Ciniselli Eleonora Bruno Alessandra Macciotta Antonino Belfiore Maria Teresa Ricci Giuliana Gargano Daniele Morelli Giovanni Apolone Marco Vitellaro A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis: Protocol Description and Preliminary Results Integrative Cancer Therapies |
| title | A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis: Protocol Description and Preliminary Results |
| title_full | A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis: Protocol Description and Preliminary Results |
| title_fullStr | A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis: Protocol Description and Preliminary Results |
| title_full_unstemmed | A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis: Protocol Description and Preliminary Results |
| title_short | A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis: Protocol Description and Preliminary Results |
| title_sort | pilot low inflammatory dietary intervention to reduce inflammation and improve quality of life in patients with familial adenomatous polyposis protocol description and preliminary results |
| url | https://doi.org/10.1177/1534735419846400 |
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