Pertussis Vaccination Failure in the New Zealand Pediatric Population: Study Protocol
Pertussis vaccines have been effective at reducing pertussis-associated morbidity and mortality. However, they have a complex array of limitations, particularly associated with the duration of protection against clinical disease and imperfect immunity (carriage and transmission). Little is known abo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/7/3/65 |
| _version_ | 1817995072892829696 |
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| author | Hannah Chisholm Anna Howe Emma Best Helen Petousis-Harris |
| author_facet | Hannah Chisholm Anna Howe Emma Best Helen Petousis-Harris |
| author_sort | Hannah Chisholm |
| collection | DOAJ |
| description | Pertussis vaccines have been effective at reducing pertussis-associated morbidity and mortality. However, they have a complex array of limitations, particularly associated with the duration of protection against clinical disease and imperfect immunity (carriage and transmission). Little is known about risk factors for pertussis vaccination failure. Understanding pertussis vaccination failure risk is most important in the paediatric population. This study aims to investigate risk factors for pertussis vaccination failure in (1) infants between birth and six weeks of age born to mothers who received pertussis booster vaccinations during pregnancy and (2) infants after the completion of the primary series (approximately five months old) to four years old. This will be achieved in a two-step process for each study group. Pertussis vaccination failure cases will first be described using a case series study design, relevant case characteristics will be sourced from six national administrative datasets. The case series study results will help select candidate risk factors (hypothesis generating step) to be tested in the retrospective cohort study (hypothesis testing step). Pattern analysis will be used to investigate risk factor patterns in the cohort study. The identification of higher risk groups enables targeting strategies, such as additional doses, to better prevent pertussis disease. |
| first_indexed | 2024-04-14T02:00:30Z |
| format | Article |
| id | doaj.art-c3c94393cb534009858181e37de02cee |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-04-14T02:00:30Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-c3c94393cb534009858181e37de02cee2022-12-22T02:18:51ZengMDPI AGVaccines2076-393X2019-07-01736510.3390/vaccines7030065vaccines7030065Pertussis Vaccination Failure in the New Zealand Pediatric Population: Study ProtocolHannah Chisholm0Anna Howe1Emma Best2Helen Petousis-Harris3Department of General Practice and Primary Health Care, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1142, New ZealandDepartment of General Practice and Primary Health Care, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1142, New ZealandDepartment of Paediatrics, Child and Youth Health, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1142, New ZealandDepartment of General Practice and Primary Health Care, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1142, New ZealandPertussis vaccines have been effective at reducing pertussis-associated morbidity and mortality. However, they have a complex array of limitations, particularly associated with the duration of protection against clinical disease and imperfect immunity (carriage and transmission). Little is known about risk factors for pertussis vaccination failure. Understanding pertussis vaccination failure risk is most important in the paediatric population. This study aims to investigate risk factors for pertussis vaccination failure in (1) infants between birth and six weeks of age born to mothers who received pertussis booster vaccinations during pregnancy and (2) infants after the completion of the primary series (approximately five months old) to four years old. This will be achieved in a two-step process for each study group. Pertussis vaccination failure cases will first be described using a case series study design, relevant case characteristics will be sourced from six national administrative datasets. The case series study results will help select candidate risk factors (hypothesis generating step) to be tested in the retrospective cohort study (hypothesis testing step). Pattern analysis will be used to investigate risk factor patterns in the cohort study. The identification of higher risk groups enables targeting strategies, such as additional doses, to better prevent pertussis disease.https://www.mdpi.com/2076-393X/7/3/65pertussisvaccination failurepediatricstudy protocol |
| spellingShingle | Hannah Chisholm Anna Howe Emma Best Helen Petousis-Harris Pertussis Vaccination Failure in the New Zealand Pediatric Population: Study Protocol Vaccines pertussis vaccination failure pediatric study protocol |
| title | Pertussis Vaccination Failure in the New Zealand Pediatric Population: Study Protocol |
| title_full | Pertussis Vaccination Failure in the New Zealand Pediatric Population: Study Protocol |
| title_fullStr | Pertussis Vaccination Failure in the New Zealand Pediatric Population: Study Protocol |
| title_full_unstemmed | Pertussis Vaccination Failure in the New Zealand Pediatric Population: Study Protocol |
| title_short | Pertussis Vaccination Failure in the New Zealand Pediatric Population: Study Protocol |
| title_sort | pertussis vaccination failure in the new zealand pediatric population study protocol |
| topic | pertussis vaccination failure pediatric study protocol |
| url | https://www.mdpi.com/2076-393X/7/3/65 |
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