Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy
Abstract As the indispensable second cellular messenger, calcium signaling is involved in the regulation of almost all physiological processes by activating specific target proteins. The importance of calcium ions (Ca2+) makes its “Janus nature” strictly regulated by its concentration. Abnormal regu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-07-01
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| Series: | Nano-Micro Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40820-022-00894-6 |
| _version_ | 1828259756638208000 |
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| author | Shuang Bai Yulu Lan Shiying Fu Hongwei Cheng Zhixiang Lu Gang Liu |
| author_facet | Shuang Bai Yulu Lan Shiying Fu Hongwei Cheng Zhixiang Lu Gang Liu |
| author_sort | Shuang Bai |
| collection | DOAJ |
| description | Abstract As the indispensable second cellular messenger, calcium signaling is involved in the regulation of almost all physiological processes by activating specific target proteins. The importance of calcium ions (Ca2+) makes its “Janus nature” strictly regulated by its concentration. Abnormal regulation of calcium signals may cause some diseases; however, artificial regulation of calcium homeostasis in local lesions may also play a therapeutic role. “Calcium overload,” for example, is characterized by excessive enrichment of intracellular Ca2+, which irreversibly switches calcium signaling from “positive regulation” to “reverse destruction,” leading to cell death. However, this undesirable death could be defined as “calcicoptosis” to offer a novel approach for cancer treatment. Indeed, Ca2+ is involved in various cancer diagnostic and therapeutic events, including calcium overload-induced calcium homeostasis disorder, calcium channels dysregulation, mitochondrial dysfunction, calcium-associated immunoregulation, cell/vascular/tumor calcification, and calcification-mediated CT imaging. In parallel, the development of multifunctional calcium-based nanomaterials (e.g., calcium phosphate, calcium carbonate, calcium peroxide, and hydroxyapatite) is becoming abundantly available. This review will highlight the latest insights of the calcium-based nanomaterials, explain their application, and provide novel perspective. Identifying and characterizing new patterns of calcium-dependent signaling and exploiting the disease element linkage offer additional translational opportunities for cancer theranostics. |
| first_indexed | 2024-04-13T03:13:27Z |
| format | Article |
| id | doaj.art-c3ca63bf4eca49929c595cc9e857f435 |
| institution | Directory Open Access Journal |
| issn | 2311-6706 2150-5551 |
| language | English |
| last_indexed | 2024-04-13T03:13:27Z |
| publishDate | 2022-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nano-Micro Letters |
| spelling | doaj.art-c3ca63bf4eca49929c595cc9e857f4352022-12-22T03:04:59ZengSpringerOpenNano-Micro Letters2311-67062150-55512022-07-0114113710.1007/s40820-022-00894-6Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to TherapyShuang Bai0Yulu Lan1Shiying Fu2Hongwei Cheng3Zhixiang Lu4Gang Liu5State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen UniversityAbstract As the indispensable second cellular messenger, calcium signaling is involved in the regulation of almost all physiological processes by activating specific target proteins. The importance of calcium ions (Ca2+) makes its “Janus nature” strictly regulated by its concentration. Abnormal regulation of calcium signals may cause some diseases; however, artificial regulation of calcium homeostasis in local lesions may also play a therapeutic role. “Calcium overload,” for example, is characterized by excessive enrichment of intracellular Ca2+, which irreversibly switches calcium signaling from “positive regulation” to “reverse destruction,” leading to cell death. However, this undesirable death could be defined as “calcicoptosis” to offer a novel approach for cancer treatment. Indeed, Ca2+ is involved in various cancer diagnostic and therapeutic events, including calcium overload-induced calcium homeostasis disorder, calcium channels dysregulation, mitochondrial dysfunction, calcium-associated immunoregulation, cell/vascular/tumor calcification, and calcification-mediated CT imaging. In parallel, the development of multifunctional calcium-based nanomaterials (e.g., calcium phosphate, calcium carbonate, calcium peroxide, and hydroxyapatite) is becoming abundantly available. This review will highlight the latest insights of the calcium-based nanomaterials, explain their application, and provide novel perspective. Identifying and characterizing new patterns of calcium-dependent signaling and exploiting the disease element linkage offer additional translational opportunities for cancer theranostics.https://doi.org/10.1007/s40820-022-00894-6Calcium-based nanomaterialsCancer therapyCalcium signalingTumor calcificationTheranostics |
| spellingShingle | Shuang Bai Yulu Lan Shiying Fu Hongwei Cheng Zhixiang Lu Gang Liu Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy Nano-Micro Letters Calcium-based nanomaterials Cancer therapy Calcium signaling Tumor calcification Theranostics |
| title | Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy |
| title_full | Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy |
| title_fullStr | Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy |
| title_full_unstemmed | Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy |
| title_short | Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy |
| title_sort | connecting calcium based nanomaterials and cancer from diagnosis to therapy |
| topic | Calcium-based nanomaterials Cancer therapy Calcium signaling Tumor calcification Theranostics |
| url | https://doi.org/10.1007/s40820-022-00894-6 |
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