Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension
Backgrounds and aims: Increased arterial stiffness may increase cardiovascular morbidity and mortality. Angiotensin II type 1 receptor blockers (ARBs) are potentially useful in controlling the central blood pressure and arterial stiffness in mild to moderate essential hypertension, while the effects...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-10-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2018.1529781 |
| _version_ | 1797681395913457664 |
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| author | Mo-Li Zhu Rui-Li Sun He-Yun Zhang Fan-Rong Zhao Guo-Pin Pan Chong Zhang Ping Song Peng Li Jian Xu Shuangxi Wang Ya-Ling Yin |
| author_facet | Mo-Li Zhu Rui-Li Sun He-Yun Zhang Fan-Rong Zhao Guo-Pin Pan Chong Zhang Ping Song Peng Li Jian Xu Shuangxi Wang Ya-Ling Yin |
| author_sort | Mo-Li Zhu |
| collection | DOAJ |
| description | Backgrounds and aims: Increased arterial stiffness may increase cardiovascular morbidity and mortality. Angiotensin II type 1 receptor blockers (ARBs) are potentially useful in controlling the central blood pressure and arterial stiffness in mild to moderate essential hypertension, while the effects of ARBs in aged patients with essential hypertension are not entirely investigated. Methods: The carotid-femoral arterial pulse wave velocity (PWV) was measured in aged patients with essential hypertension. Results: In a cross-sectional study, PWV value was significantly higher in these old patients with essential hypertension, compared to patients without essential hypertension. In correlation analysis, PWV was associated positively with age, hypertension duration, and carotid atherosclerosis. However, there was no relationship between PWV and gender in aged patients with essential hypertension. In a perspective study, 6–12 months administration of ARBs (losartan, 50 mg/day; telmisartan, 40 mg/day; valsartan 80 mg/day; irbesartan, 150 mg/day) remarkably reduced PWV in aged patients with essential hypertension. Regression analyses of multiple factors indicated that the effects of ARBs on arterial stiffness were not associated with the reduction of blood pressure. Conclusion: ARB treatment is a negative risk factor of arterial stiffness in aged patients with essential hypertension. |
| first_indexed | 2024-03-11T23:44:20Z |
| format | Article |
| id | doaj.art-c3cb756f9e5a4acaaff1c60b572e7f17 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:44:20Z |
| publishDate | 2019-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-c3cb756f9e5a4acaaff1c60b572e7f172023-09-19T15:19:27ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062019-10-0141765766110.1080/10641963.2018.15297811529781Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertensionMo-Li Zhu0Rui-Li Sun1He-Yun Zhang2Fan-Rong Zhao3Guo-Pin Pan4Chong Zhang5Ping Song6Peng Li7Jian Xu8Shuangxi Wang9Ya-Ling Yin10Xinxiang Medical UniversityXinxiang Medical UniversityXinxiang Medical UniversityXinxiang Medical UniversityXinxiang Medical UniversityXinxiang Medical UniversityXinxiang Medical UniversityXinxiang Medical UniversityXinxiang Medical UniversityXinxiang Medical UniversityXinxiang Medical UniversityBackgrounds and aims: Increased arterial stiffness may increase cardiovascular morbidity and mortality. Angiotensin II type 1 receptor blockers (ARBs) are potentially useful in controlling the central blood pressure and arterial stiffness in mild to moderate essential hypertension, while the effects of ARBs in aged patients with essential hypertension are not entirely investigated. Methods: The carotid-femoral arterial pulse wave velocity (PWV) was measured in aged patients with essential hypertension. Results: In a cross-sectional study, PWV value was significantly higher in these old patients with essential hypertension, compared to patients without essential hypertension. In correlation analysis, PWV was associated positively with age, hypertension duration, and carotid atherosclerosis. However, there was no relationship between PWV and gender in aged patients with essential hypertension. In a perspective study, 6–12 months administration of ARBs (losartan, 50 mg/day; telmisartan, 40 mg/day; valsartan 80 mg/day; irbesartan, 150 mg/day) remarkably reduced PWV in aged patients with essential hypertension. Regression analyses of multiple factors indicated that the effects of ARBs on arterial stiffness were not associated with the reduction of blood pressure. Conclusion: ARB treatment is a negative risk factor of arterial stiffness in aged patients with essential hypertension.http://dx.doi.org/10.1080/10641963.2018.1529781arterial stiffnessessential hypertensionelderlyangiotensin ii type 1 receptor blockerlosartan |
| spellingShingle | Mo-Li Zhu Rui-Li Sun He-Yun Zhang Fan-Rong Zhao Guo-Pin Pan Chong Zhang Ping Song Peng Li Jian Xu Shuangxi Wang Ya-Ling Yin Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension Clinical and Experimental Hypertension arterial stiffness essential hypertension elderly angiotensin ii type 1 receptor blocker losartan |
| title | Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension |
| title_full | Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension |
| title_fullStr | Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension |
| title_full_unstemmed | Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension |
| title_short | Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension |
| title_sort | angiotensin ii type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension |
| topic | arterial stiffness essential hypertension elderly angiotensin ii type 1 receptor blocker losartan |
| url | http://dx.doi.org/10.1080/10641963.2018.1529781 |
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