Influence of Photosensitizer on Photodynamic Therapy for Peri-Implantitis: A Systematic Review
The treatment of peri-implantitis is challenging in the clinical practice of implant dentistry. With limited therapeutic options and drug resistance, there is a need for alternative methods, such as photodynamic therapy (PDT), which is a minimally invasive procedure used to treat peri-implantitis. T...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/3/307 |
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| author | Thaís B. M. O. Schweigert João P. R. Afonso Renata K. da Palma Iransé Oliveira-Silva Carlos H. M. Silva Elias Ilias Jirjos Wilson Rodrigues Freitas Júnior Giuseppe Insalaco Orlando A. Guedes Luís V. F. Oliveira |
| author_facet | Thaís B. M. O. Schweigert João P. R. Afonso Renata K. da Palma Iransé Oliveira-Silva Carlos H. M. Silva Elias Ilias Jirjos Wilson Rodrigues Freitas Júnior Giuseppe Insalaco Orlando A. Guedes Luís V. F. Oliveira |
| author_sort | Thaís B. M. O. Schweigert |
| collection | DOAJ |
| description | The treatment of peri-implantitis is challenging in the clinical practice of implant dentistry. With limited therapeutic options and drug resistance, there is a need for alternative methods, such as photodynamic therapy (PDT), which is a minimally invasive procedure used to treat peri-implantitis. This study evaluated whether the type of photosensitizer used influences the results of inflammatory control, reduction in peri-implant pocket depth, bleeding during probing, and reduction in bone loss in the dental implant region. We registered the study in the PROSPERO (International Prospective Register of Systematic Review) database. We searched three main databases and gray literature in English without date restrictions. In vivo randomized clinical studies involving individuals with peri-implantitis, smokers, patients with diabetes, and healthy controls were included. PDT was used as the primary intervention. Comparators considered mechanical debridement with a reduction in pocket depth as the primary outcome and clinical attachment level, bleeding on probing, gingival index, plaque index, and microbiological analysis as secondary outcomes. After reviewing the eligibility criteria, we included seven articles out of 266. A great variety of photosensitizers were observed, and it was concluded that the selection of the most appropriate type of photosensitizer must consider the patient’s characteristics and peri-implantitis conditions. The effectiveness of PDT, its effects on the oral microbiome, and the clinical patterns of peri-implantitis may vary depending on the photosensitizer chosen, which is a crucial factor in personalizing peri-implantitis treatment. |
| first_indexed | 2024-04-24T17:55:26Z |
| format | Article |
| id | doaj.art-c3cca548b9ab4cd9bc9eeac63259072b |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-24T17:55:26Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-c3cca548b9ab4cd9bc9eeac63259072b2024-03-27T13:59:33ZengMDPI AGPharmaceutics1999-49232024-02-0116330710.3390/pharmaceutics16030307Influence of Photosensitizer on Photodynamic Therapy for Peri-Implantitis: A Systematic ReviewThaís B. M. O. Schweigert0João P. R. Afonso1Renata K. da Palma2Iransé Oliveira-Silva3Carlos H. M. Silva4Elias Ilias Jirjos5Wilson Rodrigues Freitas Júnior6Giuseppe Insalaco7Orlando A. Guedes8Luís V. F. Oliveira9Health Sciences, Post-Graduation Program, Faculty of Medical Sciences of Santa Casa de São Paulo (FCMSCSP), São Paulo 01224-001, SP, BrazilHuman Movement and Rehabilitation, Post-Graduation Program, Evangelical University of Goiás—UniEVANGÉLICA, Anápolis 75083-515, GO, BrazilHuman Movement and Rehabilitation, Post-Graduation Program, Evangelical University of Goiás—UniEVANGÉLICA, Anápolis 75083-515, GO, BrazilHuman Movement and Rehabilitation, Post-Graduation Program, Evangelical University of Goiás—UniEVANGÉLICA, Anápolis 75083-515, GO, BrazilHuman Movement and Rehabilitation, Post-Graduation Program, Evangelical University of Goiás—UniEVANGÉLICA, Anápolis 75083-515, GO, BrazilHealth Sciences, Post-Graduation Program, Faculty of Medical Sciences of Santa Casa de São Paulo (FCMSCSP), São Paulo 01224-001, SP, BrazilHealth Sciences, Post-Graduation Program, Faculty of Medical Sciences of Santa Casa de São Paulo (FCMSCSP), São Paulo 01224-001, SP, BrazilInstitute of Translational Pharmacology, National Research Council of Italy (CNR), 90146 Palermo, ItalyDentistry, Post-Graduation Program, Evangelical University of Goiás—UniEVANGÉLICA, Anápolis 75083-515, GO, BrazilHealth Sciences, Post-Graduation Program, Faculty of Medical Sciences of Santa Casa de São Paulo (FCMSCSP), São Paulo 01224-001, SP, BrazilThe treatment of peri-implantitis is challenging in the clinical practice of implant dentistry. With limited therapeutic options and drug resistance, there is a need for alternative methods, such as photodynamic therapy (PDT), which is a minimally invasive procedure used to treat peri-implantitis. This study evaluated whether the type of photosensitizer used influences the results of inflammatory control, reduction in peri-implant pocket depth, bleeding during probing, and reduction in bone loss in the dental implant region. We registered the study in the PROSPERO (International Prospective Register of Systematic Review) database. We searched three main databases and gray literature in English without date restrictions. In vivo randomized clinical studies involving individuals with peri-implantitis, smokers, patients with diabetes, and healthy controls were included. PDT was used as the primary intervention. Comparators considered mechanical debridement with a reduction in pocket depth as the primary outcome and clinical attachment level, bleeding on probing, gingival index, plaque index, and microbiological analysis as secondary outcomes. After reviewing the eligibility criteria, we included seven articles out of 266. A great variety of photosensitizers were observed, and it was concluded that the selection of the most appropriate type of photosensitizer must consider the patient’s characteristics and peri-implantitis conditions. The effectiveness of PDT, its effects on the oral microbiome, and the clinical patterns of peri-implantitis may vary depending on the photosensitizer chosen, which is a crucial factor in personalizing peri-implantitis treatment.https://www.mdpi.com/1999-4923/16/3/307photodynamic therapyperi-implantitisphotosensitizer |
| spellingShingle | Thaís B. M. O. Schweigert João P. R. Afonso Renata K. da Palma Iransé Oliveira-Silva Carlos H. M. Silva Elias Ilias Jirjos Wilson Rodrigues Freitas Júnior Giuseppe Insalaco Orlando A. Guedes Luís V. F. Oliveira Influence of Photosensitizer on Photodynamic Therapy for Peri-Implantitis: A Systematic Review Pharmaceutics photodynamic therapy peri-implantitis photosensitizer |
| title | Influence of Photosensitizer on Photodynamic Therapy for Peri-Implantitis: A Systematic Review |
| title_full | Influence of Photosensitizer on Photodynamic Therapy for Peri-Implantitis: A Systematic Review |
| title_fullStr | Influence of Photosensitizer on Photodynamic Therapy for Peri-Implantitis: A Systematic Review |
| title_full_unstemmed | Influence of Photosensitizer on Photodynamic Therapy for Peri-Implantitis: A Systematic Review |
| title_short | Influence of Photosensitizer on Photodynamic Therapy for Peri-Implantitis: A Systematic Review |
| title_sort | influence of photosensitizer on photodynamic therapy for peri implantitis a systematic review |
| topic | photodynamic therapy peri-implantitis photosensitizer |
| url | https://www.mdpi.com/1999-4923/16/3/307 |
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