Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament
The importance of skeletal muscles in the development of osteoarthritis (OA) is known. However, in OA, strengthening the muscle is arduous process. This study investigated the effects of muscle enhancement and support therapy (MEST), a novel device for the intramuscular insertion of cog polydioxanon...
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MDPI AG
2021-11-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/22/10534 |
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| author | Kilyong Lee Geung Gyu Gang Yun Gyu Kang Sung Sam Jung Hee-Gon Park Jun Ho Jang |
| author_facet | Kilyong Lee Geung Gyu Gang Yun Gyu Kang Sung Sam Jung Hee-Gon Park Jun Ho Jang |
| author_sort | Kilyong Lee |
| collection | DOAJ |
| description | The importance of skeletal muscles in the development of osteoarthritis (OA) is known. However, in OA, strengthening the muscle is arduous process. This study investigated the effects of muscle enhancement and support therapy (MEST), a novel device for the intramuscular insertion of cog polydioxanone filament intended to hold and stimulate surrounding muscles, on OA-induced symptoms. In our results, the MEST attenuated OA-induced pain and mobility limitations, as evidenced by increases in withdrawal thresholds, rearing duration and travelled distance in an open cage, and fall latency from rotarod. It further restored atrophic rectus femoris muscle (RFM) in OA animals by increasing mass, decreasing nucleus density, and increasing the cross-sectional area of muscle fibers. Decreased collagen and insulin-like growth factor 1 levels in OA animals were restored without affecting the interleukin-6 and tumor necrosis factor-alpha levels in RFM. No evidence of structural improvement in the knee was observed via computed tomography after MEST. These results suggest that MEST in the quadriceps is effective for relieving pain and motor impairment in knee OA animals by restoring atrophic muscles, providing a novel therapeutic strategy for OA symptom management. |
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| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T05:44:31Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
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| series | Applied Sciences |
| spelling | doaj.art-c3cd90d9f6f645098f4493504aeb714b2023-11-22T22:15:08ZengMDPI AGApplied Sciences2076-34172021-11-0111221053410.3390/app112210534Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone FilamentKilyong Lee0Geung Gyu Gang1Yun Gyu Kang2Sung Sam Jung3Hee-Gon Park4Jun Ho Jang5Spine Center, Seoul Yes Hospital, Yongin 16868, Gyeonggi-do, KoreaResearch Institute, OV MEDI Co., Ltd., Seongnam 13494, Gyeonggi-do, KoreaResearch Institute, OV MEDI Co., Ltd., Seongnam 13494, Gyeonggi-do, KoreaNeurosurgery Department, Yonseibarean Neurosurgery Clinic, Anyang 14001, Gyeonggi-do, KoreaDepartment of Orthopedic Surgery, Dankook University College of Medicine, Cheonan 31116, Chungcheongnam-do, KoreaResearch Institute, OV MEDI Co., Ltd., Seongnam 13494, Gyeonggi-do, KoreaThe importance of skeletal muscles in the development of osteoarthritis (OA) is known. However, in OA, strengthening the muscle is arduous process. This study investigated the effects of muscle enhancement and support therapy (MEST), a novel device for the intramuscular insertion of cog polydioxanone filament intended to hold and stimulate surrounding muscles, on OA-induced symptoms. In our results, the MEST attenuated OA-induced pain and mobility limitations, as evidenced by increases in withdrawal thresholds, rearing duration and travelled distance in an open cage, and fall latency from rotarod. It further restored atrophic rectus femoris muscle (RFM) in OA animals by increasing mass, decreasing nucleus density, and increasing the cross-sectional area of muscle fibers. Decreased collagen and insulin-like growth factor 1 levels in OA animals were restored without affecting the interleukin-6 and tumor necrosis factor-alpha levels in RFM. No evidence of structural improvement in the knee was observed via computed tomography after MEST. These results suggest that MEST in the quadriceps is effective for relieving pain and motor impairment in knee OA animals by restoring atrophic muscles, providing a novel therapeutic strategy for OA symptom management.https://www.mdpi.com/2076-3417/11/22/10534osteoarthritisskeletal musclepainmotor impairmentpolydioxanone |
| spellingShingle | Kilyong Lee Geung Gyu Gang Yun Gyu Kang Sung Sam Jung Hee-Gon Park Jun Ho Jang Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament Applied Sciences osteoarthritis skeletal muscle pain motor impairment polydioxanone |
| title | Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament |
| title_full | Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament |
| title_fullStr | Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament |
| title_full_unstemmed | Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament |
| title_short | Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament |
| title_sort | alleviation of osteoarthritis induced pain and motor deficits in rats by a novel device for the intramuscular insertion of cog polydioxanone filament |
| topic | osteoarthritis skeletal muscle pain motor impairment polydioxanone |
| url | https://www.mdpi.com/2076-3417/11/22/10534 |
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