Ulcerative colitis: Al-gassim experience
<i>Background: </i> Ulcerative colitis (UC) is being reported more frequently among the Arabs. Information on the clinical severity, endoscopic and histological grading is scanty. <i> Aim: </i> To assess the severity of the disease and its response to therapy in patients refe...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2004-01-01
|
| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2004;volume=10;issue=1;spage=22;epage=27;aulast=Contractor |
| _version_ | 1818909584356540416 |
|---|---|
| author | Contractor Qais Contractor Tasneern Ul Haque Imran El Mahdi El Mahdi |
| author_facet | Contractor Qais Contractor Tasneern Ul Haque Imran El Mahdi El Mahdi |
| author_sort | Contractor Qais |
| collection | DOAJ |
| description | <i>Background: </i> Ulcerative colitis (UC) is being reported more frequently among the Arabs. Information on the clinical severity, endoscopic and histological grading is scanty. <i> Aim: </i> To assess the severity of the disease and its response to therapy in patients referred to a tertiary care referral centre in Gassim region, Kingdom of Saudi Arabia (KSA). <i> Patients and Method: </i> Hospital records of thirty-four patients found to have UC from 1990-2002 were analyzed. The study included clinical severity, endoscopical and histological assessment, response to therapy and frequency of complications. <i> Results: </i> There were 21 males and 13 females with median age 35 (range: 18-76) years. The disease was clinically mild in seven patients (21%), moderate in 11 (32%) and severe in 16 (47%). Endoscopically UC was graded as 2 in three patients (9%), 3 in 21 patients (59%) and 4 in ten patients (29%). Histologically UC was mild to moderate in 11 patients (32%) and severe in 23 (68%). Extent of UC was total in nine patients (26%), up to transverse colon in six (18%), splenic flexure in 14 (41%), rectosigmoid region in four (12%) and only up to the rectum in one (3%). Twenty-nine patients (85%) were treated with salazopyrine and five patients (15%); (two of them were hypersensitive to salazopyrine) received 5-aminosalicylic acid. Proctocolectomy was performed in two with a focus of malignancy. No patient died during the median follow-up period of 48 months (range: 4 months to 12 years). <i> Conclusion: </i> Ulcerative colitis presented with varying severity, more frequently in males in the population studied. Most of the patients responded to salazopyrine and surgery was necessary when malignancy was detected |
| first_indexed | 2024-12-19T22:29:14Z |
| format | Article |
| id | doaj.art-c3d11d98d327411c80db2620f7beccb0 |
| institution | Directory Open Access Journal |
| issn | 1319-3767 |
| language | English |
| last_indexed | 2024-12-19T22:29:14Z |
| publishDate | 2004-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-c3d11d98d327411c80db2620f7beccb02022-12-21T20:03:24ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37672004-01-011012227Ulcerative colitis: Al-gassim experienceContractor QaisContractor TasneernUl Haque ImranEl Mahdi El Mahdi<i>Background: </i> Ulcerative colitis (UC) is being reported more frequently among the Arabs. Information on the clinical severity, endoscopic and histological grading is scanty. <i> Aim: </i> To assess the severity of the disease and its response to therapy in patients referred to a tertiary care referral centre in Gassim region, Kingdom of Saudi Arabia (KSA). <i> Patients and Method: </i> Hospital records of thirty-four patients found to have UC from 1990-2002 were analyzed. The study included clinical severity, endoscopical and histological assessment, response to therapy and frequency of complications. <i> Results: </i> There were 21 males and 13 females with median age 35 (range: 18-76) years. The disease was clinically mild in seven patients (21%), moderate in 11 (32%) and severe in 16 (47%). Endoscopically UC was graded as 2 in three patients (9%), 3 in 21 patients (59%) and 4 in ten patients (29%). Histologically UC was mild to moderate in 11 patients (32%) and severe in 23 (68%). Extent of UC was total in nine patients (26%), up to transverse colon in six (18%), splenic flexure in 14 (41%), rectosigmoid region in four (12%) and only up to the rectum in one (3%). Twenty-nine patients (85%) were treated with salazopyrine and five patients (15%); (two of them were hypersensitive to salazopyrine) received 5-aminosalicylic acid. Proctocolectomy was performed in two with a focus of malignancy. No patient died during the median follow-up period of 48 months (range: 4 months to 12 years). <i> Conclusion: </i> Ulcerative colitis presented with varying severity, more frequently in males in the population studied. Most of the patients responded to salazopyrine and surgery was necessary when malignancy was detectedhttp://www.saudijgastro.com/article.asp?issn=1319-3767;year=2004;volume=10;issue=1;spage=22;epage=27;aulast=ContractorUlcerative colitisinflammatory bowel diseasecolitis. |
| spellingShingle | Contractor Qais Contractor Tasneern Ul Haque Imran El Mahdi El Mahdi Ulcerative colitis: Al-gassim experience The Saudi Journal of Gastroenterology Ulcerative colitis inflammatory bowel disease colitis. |
| title | Ulcerative colitis: Al-gassim experience |
| title_full | Ulcerative colitis: Al-gassim experience |
| title_fullStr | Ulcerative colitis: Al-gassim experience |
| title_full_unstemmed | Ulcerative colitis: Al-gassim experience |
| title_short | Ulcerative colitis: Al-gassim experience |
| title_sort | ulcerative colitis al gassim experience |
| topic | Ulcerative colitis inflammatory bowel disease colitis. |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2004;volume=10;issue=1;spage=22;epage=27;aulast=Contractor |
| work_keys_str_mv | AT contractorqais ulcerativecolitisalgassimexperience AT contractortasneern ulcerativecolitisalgassimexperience AT ulhaqueimran ulcerativecolitisalgassimexperience AT elmahdielmahdi ulcerativecolitisalgassimexperience |