Recent advances in endothelial colony-forming cells: from the transcriptomic perspective
Abstract Endothelial colony-forming cells (ECFCs) are progenitors of endothelial cells with significant proliferative and angiogenic ability. ECFCs are a promising treatment option for various diseases, such as ischemic heart disease and peripheral artery disease. However, some barriers hinder the c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-024-05108-8 |
| _version_ | 1797233350083084288 |
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| author | Yaqiong Liu Caomhán J. Lyons Christine Ayu Timothy O’Brien |
| author_facet | Yaqiong Liu Caomhán J. Lyons Christine Ayu Timothy O’Brien |
| author_sort | Yaqiong Liu |
| collection | DOAJ |
| description | Abstract Endothelial colony-forming cells (ECFCs) are progenitors of endothelial cells with significant proliferative and angiogenic ability. ECFCs are a promising treatment option for various diseases, such as ischemic heart disease and peripheral artery disease. However, some barriers hinder the clinical application of ECFC therapeutics. One of the current obstacles is that ECFCs are dysfunctional due to the underlying disease states. ECFCs exhibit dysfunctional phenotypes in pathologic states, which include but are not limited to the following: premature neonates and pregnancy-related diseases, diabetes mellitus, cancers, haematological system diseases, hypoxia, pulmonary arterial hypertension, coronary artery diseases, and other vascular diseases. Besides, ECFCs are heterogeneous among donors, tissue sources, and within cell subpopulations. Therefore, it is important to elucidate the underlying mechanisms of ECFC dysfunction and characterize their heterogeneity to enable clinical application. In this review, we summarize the current and potential application of transcriptomic analysis in the field of ECFC biology. Transcriptomic analysis is a powerful tool for exploring the key molecules and pathways involved in health and disease and can be used to characterize ECFC heterogeneity. |
| first_indexed | 2024-04-24T16:14:46Z |
| format | Article |
| id | doaj.art-c3d3f2cdd2be4a06a05aff43601d916a |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-24T16:14:46Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-c3d3f2cdd2be4a06a05aff43601d916a2024-03-31T11:33:46ZengBMCJournal of Translational Medicine1479-58762024-03-0122111710.1186/s12967-024-05108-8Recent advances in endothelial colony-forming cells: from the transcriptomic perspectiveYaqiong Liu0Caomhán J. Lyons1Christine Ayu2Timothy O’Brien3Regenerative Medicine Institute (REMEDI), Biomedical Sciences Building, University of GalwayRegenerative Medicine Institute (REMEDI), Biomedical Sciences Building, University of GalwayRegenerative Medicine Institute (REMEDI), Biomedical Sciences Building, University of GalwayRegenerative Medicine Institute (REMEDI), Biomedical Sciences Building, University of GalwayAbstract Endothelial colony-forming cells (ECFCs) are progenitors of endothelial cells with significant proliferative and angiogenic ability. ECFCs are a promising treatment option for various diseases, such as ischemic heart disease and peripheral artery disease. However, some barriers hinder the clinical application of ECFC therapeutics. One of the current obstacles is that ECFCs are dysfunctional due to the underlying disease states. ECFCs exhibit dysfunctional phenotypes in pathologic states, which include but are not limited to the following: premature neonates and pregnancy-related diseases, diabetes mellitus, cancers, haematological system diseases, hypoxia, pulmonary arterial hypertension, coronary artery diseases, and other vascular diseases. Besides, ECFCs are heterogeneous among donors, tissue sources, and within cell subpopulations. Therefore, it is important to elucidate the underlying mechanisms of ECFC dysfunction and characterize their heterogeneity to enable clinical application. In this review, we summarize the current and potential application of transcriptomic analysis in the field of ECFC biology. Transcriptomic analysis is a powerful tool for exploring the key molecules and pathways involved in health and disease and can be used to characterize ECFC heterogeneity.https://doi.org/10.1186/s12967-024-05108-8Endothelial colony forming cellsTranscriptome analysisCell dysfunctionHeterogeneity |
| spellingShingle | Yaqiong Liu Caomhán J. Lyons Christine Ayu Timothy O’Brien Recent advances in endothelial colony-forming cells: from the transcriptomic perspective Journal of Translational Medicine Endothelial colony forming cells Transcriptome analysis Cell dysfunction Heterogeneity |
| title | Recent advances in endothelial colony-forming cells: from the transcriptomic perspective |
| title_full | Recent advances in endothelial colony-forming cells: from the transcriptomic perspective |
| title_fullStr | Recent advances in endothelial colony-forming cells: from the transcriptomic perspective |
| title_full_unstemmed | Recent advances in endothelial colony-forming cells: from the transcriptomic perspective |
| title_short | Recent advances in endothelial colony-forming cells: from the transcriptomic perspective |
| title_sort | recent advances in endothelial colony forming cells from the transcriptomic perspective |
| topic | Endothelial colony forming cells Transcriptome analysis Cell dysfunction Heterogeneity |
| url | https://doi.org/10.1186/s12967-024-05108-8 |
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